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T9303MRTX1133KRAS,Ras,MRTX 1133,G12D,cells,active,wild-type,phosphorylation,mutant,MRTX1133,inactive,ERK,
MRTX1133 is a potent, selective, and noncovalent inhibitor of KRAS G12D. MRTX1133 exhibits an estimated KD against KRAS G12D of 0.2 pM. MRTX1133 inhibits mutant KRAS-dependent signal transduction by preventing SOS1-catalyzed nucleotide exchange and/or formation of the KRAS G12D/GTP/RAF1 complex. MRTX1133 selectively inhibits KRAS G12D mutant tumor cells with no effect on KRAS wild-type. MRTX1133 exhibits single digit nanomolar activity in cellular assays and marked in vivo efficacy in tumor mode
价 格：￥电议型 号：T9303产 地：中国大陆
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T9373DCH36_06HATs,hypoacetylation,Apoptosis,DCH-36_06,inhibit,antiproliferative,p300,HAT,DCH36_06,Inhibit
DCH36_06? as a bona fide is a potent p300/CBP inhibitor
价 格：￥电议型 号：T9373产 地：中国大陆
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T7122AZD-7648DNA-dependent protein kinase,inhibit,Apoptosis,AZD7648,A549,OAW42,PI3K,Inhibitor,Phosphoinos
AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.
价 格：￥电议型 号：T7122产 地：中国大陆
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TN1046MurrayoneInhibitor,chemopreventive,agent,metastasis,Murrayone,inhibit,Cancer
Murrayone, a coumarin-containing compound extracted from M. paniculata, is the most bioactive substance in this species and is a cancer metastasis chemopreventive agent based on its unique pharmacological properties.Murrayone can significantly inhibit the abnormal increase of platelet aggregation induced by ADP.
价 格：￥电议型 号：TN1046产 地：中国大陆
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T7897PK150Bacterial,MRSA,MSSA,Gram-positive,PK-150,antibacterial,PK 150,PK150,Inhibitor,VISA,inhibit
PK150 shows oral bioavailability and antibacterial activity against several pathogenic strains at submicromolar concentrations.
价 格：￥电议型 号：T7897产 地：中国大陆
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T9027CA-4948rheumatoid,inflammation,CD135,inhibit,IL-1R associated kinase,CA4948,lymphoma,Interleukin-1 r
Emavusertib is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity.
价 格：￥电议型 号：T9027产 地：中国大陆
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TN50882,6-DimethoxyphenolInhibitor,plant,2,6-Dimethoxyphenol,2,6Dimethoxyphenol,inhibit,2,6 Dimethoxypheno
2,6-Dimethoxyphenol is a natural product and can be used for the measurement of laccase activity.
价 格：￥电议型 号：TN5088产 地：中国大陆
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T7388GSK805GSK 805,immunity,RAR-related orphan receptor,Inhibitor,GSK805,inhibit,ROR,oral,CNS penetrant,G
GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor´s putative ligand binding domain without exerting significant effects on DNA binding
价 格：￥电议型 号：T7388产 地：中国大陆
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TQ0126Mirodenafil dihydrochlorideSK3530,Inhibitor,Wnt,Beta catenin,Mirodenafil,SK-3530,MRC-5 cells,Miroden
Mirodenafil dihydrochloride is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.
价 格：￥电议型 号：TQ0126产 地：中国大陆
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T8798MSA-2interferon-β,Inhibitor,TMEM173,ERIS,MPYS,immunity,secretion,tumor,Stimulator of Interferon Gene
MSA-2 is a potent and orally available non-nucleotide STING agonist.
价 格：￥电议型 号：T8798产 地：中国大陆
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T6S0084TuberostemonineNADP+,Parasite,Tuberostemonine,Inhibitor,antimalarial,pfFNR,reductases,falciparum,inh
1. Tuberstemonine exhibits relatively higher intestinal permeabilities. 2. Tuberstemonine acts in part as an open-channel blocker at the crayfish neuromuscular junction.
价 格：￥电议型 号：T6S0084产 地：中国大陆
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TN2018Orientin-2’’-O-p-trans-coumarateOrientin2’’Optranscoumarate,Orientin 2’’ O p trans coumarate
Orientin-2´´-O-p-trans-coumarate is isolated from Trigonella foenum-graecum. Orientin-2´´-O-p-trans-coumarate shows antioxidant activity and promotes cell proliferation.
价 格：￥电议型 号：TN2018产 地：中国大陆
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TN1933MitraphyllineUncaria,Mitraphylline,tomentosa,Inhibitor,inhibit
Mitraphylline has antiproliferative effects on human glioma and neuroblastoma cell lines. It also has anti-inflammatory activity, it inhibits lipopolysaccharide-mediated activation of primary human neutrophils.
价 格：￥电议型 号：TN1933产 地：中国大陆
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T9962Mepolizumabeosinophil proliferation,neutralizes interleukin-5,Interleukin Related,IL-5,Mepolizumab,e
Mepolizumab is a humanized monoclonal antibody neutralizing IL-5. Mepolizumab can be used in studies about severe eosinophilic asthma and eosinophilic granulomatosis with polyangiitis.
价 格：￥电议型 号：T9962产 地：中国大陆
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T9499Icenticaftorinhibit,Icenticaftor,COPD,CFTR,QBW 251,cystic,Inhibitor,G551D,Cystic fibrosis transmembr
Icenticaftor is an orally active potentiator of?CFTR channel.
价 格：￥电议型 号：T9499产 地：中国大陆
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T8813Tetrakis (4-carboxyphenyl) porphyrinTetrakis (4-carboxyphenyl) porphyrin,inhibit,Inhibitor,Tetrakis
Tetrakis (4-carboxyphenyl) porphyrin plays the role of a metal remover.Tetrakis (4-carboxyphenyl) porphyrin is a fabricated three dimensional Ru polymer complex. It can be grafted on SiO2/Nb2O5 substrate and subsequently metallized to investigate catalytic oxidation of hydrazine
价 格：￥电议型 号：T8813产 地：中国大陆
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TP1271LCalmodulin-Dependent Protein Kinase II 290-309 acetateCalmodulin Dependent Protein Kinase II 290 309
Calmodulin-Dependent Protein Kinase II 290-309 acetate is an effective antagonist of Ca2+/calmodulin-dependent protein kinase II (IC50 = 52 nM).
价 格：￥电议型 号：TP1271L产 地：中国大陆
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TL0008Gigantolinhibit,Wnt,Gigantol,Inhibitor
Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a promising neuroprotective agent for successful MSC transplantation in ischemic diseases, it shows the protective effect against hydrogen peroxide-induced apoptosis in rat bone marrow mesenchymal stem cells through the PI3K/Akt pathway.Gigantol inhibits aldose reductase gene to e
价 格：￥电议型 号：TL0008产 地：中国大陆
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TQ0184Chebulinic acidInhibitor,Transforming growth factor beta,inhibit,Proton Pump,DNA/RNA Synthesis,Chebu
Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
价 格：￥电议型 号：TQ0184产 地：中国大陆
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T4518Licochalcone DLicochalcone D,Apoptosis,A375,anti-cancer,antioxidant,Reactive Oxygen Species,Nuclear
Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking cell migration and invasion. Licochalcone D has cardioprotective potential against myocardial ischemia/reperfusion injury in langendorff-perfused rat hearts. Licochalcone D has anti-inflammatory activity, it shows suppression ability of nitric oxide (NO) production. Licochalcone D has anti-allergic activity, it suppresses degranulation by
价 格：￥电议型 号：T4518产 地：中国大陆
