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T6228IrinotecanIrinotecan,CPT-11,(+)-Irinotecan
Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisome
价 格：￥电议型 号：T6228产 地：美洲
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T8344CPTH2；化合物CPTH2CPTH2
CPTH2 is a histone acetyltransferase inhibitor modulating Gcn5 network.
价 格：￥电议型 号：T8344产 地：中国大陆
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T81752MP-PEG8-Val-Lys-Gly-7-MAD-MDCPT；化合物 MP-PEG8-Val-Lys-Gly-7-MAD-MDCPTMP-PEG8-Val-Lys-Gly-7-MAD-MDCPT
MP-PEG8-Val-Lys-Gly-7-MAD-MDCPT is an agent-linker conjugate designed for antibody-drug conjugate (ADC) applications, with potential use in cancer and autoimmune disease research.
价 格：￥电议型 号：T81752产 地：中国大陆
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T78569CPT2；化合物 CPT2Carnitine palmitoyltransferase 2；Carnitine palmitoyltransferase 2
Carnitine palmitoyltransferase 2 (CPT2), an enzyme involved in fatty acid oxidation, serves as a prognostic biomarker for colorectal cancer (CRC). Overexpression of CPT2 activates phosphorylated p53, enhancing its expression, which in turn suppresses tumor growth and induces apoptosis. Conversely, a deficiency in CPT2 leads to the prevalent hereditary disorder of long-chain fatty acid oxidation in skeletal muscle. Additionally, the downregulation of CPT2 correlates strongly with the advancement
价 格：￥电议型 号：T78569产 地：中国大陆
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T77873NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride；化合物 NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydroc
Compound I, NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride, is a topoisomerase I inhibitor that demonstrates effective antibody-drug conjugate (ADC) activity both in vivo and in vitro, with delivery to cells facilitated through targeted antibody conjugation [1].
价 格：￥电议型 号：T77873产 地：中国大陆
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T74751Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT；化合物 Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCP
Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT (Formula V) is a conjugate comprising a potent topoisomerase I inhibitor linked to an antibody agent conjugate (ADC) [1] through a specialized linker.
价 格：￥电议型 号：T74751产 地：中国大陆
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T74750NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT；化合物 NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPTNH2-bicyclo[1.1.1]pen
Compound I, NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT, is a topoisomerase I inhibitor with the capability for targeted delivery to cells via conjugated antibodies. It exhibits effective ADC activity both in vivo and in vitro [1].
价 格：￥电议型 号：T74750产 地：中国大陆
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T7347CU-CPT-8m；化合物CU-CPT-8mTLR8-specific antagonist；TLR8-specific antagonist
CU-CPT-8m (TLR8-specific antagonist) is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)
价 格：￥电议型 号：T7347产 地：中国大陆
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T73422CPT-Se4；化合物 CPT-Se4CPT-Se4
CPT-Se4, a seleno-derivative of Camptothecin (CPT), exhibits enhanced efficacy in cancer cell eradication and tumor suppression. It reduces the GSH/GSSG balance and total thiol content while increasing ROS concentrations in Hep G2 cells, leading to the induction of cancer cell apoptosis. Furthermore, CPT-Se4 demonstrates cytotoxicity towards a range of cell lines including HeLa, Hep G2, A549, and SMMC-7721, with IC50 values ranging from 2.54 to 6.4 μM [1].
价 格：￥电议型 号：T73422产 地：中国大陆
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T73421CPT-Se3；化合物 CPT-Se3CPT-Se3
CPT-Se3, a camptothecin (CPT) seleno-derivative, exhibits enhanced anticancer efficacy by effectively killing cancer cells and hindering tumor proliferation. This compound diminishes the GSH/GSSG ratio and total thiols while increasing ROS levels, ultimately triggering apoptosis in Hep G2 cells. Furthermore, CPT-Se3 demonstrates significant cytotoxicity against HeLa, Hep G2, A549, and SMMC-7721 cell lines with IC50 values ranging from 2.19 to 4.7 μM [1].
价 格：￥电议型 号：T73421产 地：中国大陆
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T7317CU-CPT-9a；化合物CU-CPT-9aCU-CPT-9a
CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-
价 格：￥电议型 号：T7317产 地：中国大陆
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T7302CU-CPT9b；化合物CU-CPT9bCU-CPT-9b|||TLR8-specific antagonist 1；CU-CPT-9b|||TLR8-specific antagonist 1
CU-CPT9b (TLR8-specific antagonist 1) is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF- B induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells with an IC50 value of 0.7 nM.
价 格：￥电议型 号：T7302产 地：中国大陆
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T72756Gly-7-MAD-MDCPT；化合物 Gly-7-MAD-MDCPTGly-7-MAD-MDCPT
Gly-7-MAD-MDCPT is an anticancer agent. Gly-7-MAD-MDCPT is a Camptothecin compound, it shows cytotoxicity to various cancer cells with IC 50 values of 10-1000 nM [1] .
价 格：￥电议型 号：T72756产 地：中国大陆
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T64643Rh2(S-TCPTAD)4；化合物 Rh2(S-TCPTAD)4Rh2(S-TCPTAD)4
Rh2(S-TCPTAD)4 is a useful organic compound for research related to life sciences and the catalog number is T64643.
价 格：￥电议型 号：T64643产 地：中国大陆
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T6228Irinotecan；伊立替康CPT-11|||Topotecin|||(+)-Irinotecan；CPT-11|||Topotecin|||伊立替康|||(+)-Irinotecan
Irinotecan (CPT-11), a derivative of camptothecin, is an inhibitor of DNA topoisomerase I (Topo I). Irinotecan has antitumor activity by preventing DNA strand reattachment through binding to the Topo I complex, resulting in double-stranded DNA breaks and cell death.
价 格：￥电议型 号：T6228产 地：中国大陆
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T49529-Hydroxycamptothecin；9-羟基喜树碱9-HCPT|||10-Hydroxycampothecin；9-HCPT|||9-羟基喜树碱|||10-Hydroxycampothecin
9-Hydroxycampothecin is a camptothecin derivative with anticancer activity.
价 格：￥电议型 号：T4952产 地：中国大陆
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T408797-MAD-MDCPT；7-MAD-MDCPT7-MAD-MDCPT
7-MAD-MDCPT, a Camptothecin analog, is a toxin payload in antibody drug conjugates (ADCs).
价 格：￥电议型 号：T40879产 地：中国大陆
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T3S19579-amino-CPT；9-氨基喜树碱Aminocamptothecin|||9-amino-2(S)-camptothecin|||9-Aminocamptothecin；9-氨基喜树碱|||Ami
9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.
价 格：￥电议型 号：T3S1957产 地：中国大陆
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T39941MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT；MP-PEG4-Val-Lys-Gly-7-MAD-MDCPTMP-PEG4-Val-Lys-Gly-7-MAD-MDCPT；MP-PE
MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT is a Camptothecin-linker. MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT is a drug-linker conjugate for antibody-drug conjugate (ADC).
价 格：￥电议型 号：T39941产 地：中国大陆
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T38696Rp-8-CPT-cAMPS；Rp-8-CPT-cAMPSRp-8-CPT-cAMPS
Rp-8-CPT-cAMPS is a powerful and competitive antagonist of cAMP-induced activation of cAMP-dependent protein kinase (PKA) I and II. Acting as a potent cAMP analog, Rp-8-CPT-cAMPS exhibits a preference for site A of RI over site A of RII. Additionally, it favors site B of RII over site B of RI. This compound effectively inhibits cAMP-dependent PKA activation and demonstrates selectivity in binding to specific sites within the protein kinase.
价 格：￥电议型 号：T38696产 地：中国大陆
