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T14423Azido-PEG3-Ala-Boc;化合物 T14423Azido-PEG3-Ala-Boc
Azido-PEG3-Ala-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T14423产 地:中国大陆
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T14403Azido-PEG1-Boc;化合物 T14403Azido-PEG1-Boc
Azido-PEG1-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T14403产 地:中国大陆
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T14393Azide-PEG3-C1-Ala;化合物 T14393Azide-PEG3-C1-Ala
Azide-PEG3-C1-Ala is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T14393产 地:中国大陆
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T14383AZD8329;化合物 T14383AZD8329
AZD8329 is a selectable and potent inhibitor of human recombinant 11β-HSD1 and isolated human adipocyte 11?-HSD1 and is an inhibitor of rat 11β-HSD1 (IC50 - 89nM) and dog recombinant 11β-HSD1. AZD8329 has a higher affinity for 11β-HSD1 than human recombinant 11β-HSD2 and 17 AZD8329 has the ability to reduce the activity of 11β-HSD1 in adipose tissue and liver samples.
价 格:¥电议型 号:T14383产 地:中国大陆
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T14377AZD5423;化合物AZD5423AZD5423
AZD5423 is an inhaled, potent, selective, and non-steroidal modulator of glucocorticoid receptor (GR) and it effectively reduces allergen-induced responses in subjects with mild allergic asthma.
价 格:¥电议型 号:T14377产 地:中国大陆
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T14373AZD2423;化合物 T14373AZD2423
AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM for CCR2 Ca2+ flux [1][2][3].
价 格:¥电议型 号:T14373产 地:中国大陆
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T14363AZ-23;化合物AZ-23AZ 23|||AZ23;AZ 23|||AZ23
AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C. For TrkA, TrkB, FGFR1, Flt3, Ret, MuSk, Lck, the IC50s values are 2 nM, 8 nM, 24 nM, 52 nM, 55 nM, 84 nM, 99 nM, respectively.
价 格:¥电议型 号:T14363产 地:中国大陆
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T14343Atreleuton;化合物 T14343ABT-761|||VIA-2291;ABT-761|||VIA-2291
Atreleuton (ABT-761) is a potent and selective inhibitor of leukotriene formation[1][2][3]. As a reversible and orally bioavailable 5-Lipoxygenase (5-LO) inhibitor, Atreleuton (ABT-761) exhibits selectivity.
价 格:¥电议型 号:T14343产 地:中国大陆
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T14293Annonacin;化合物 T14293Annonacin
Annonacin is an Acetogenin and promotes cytotoxicity via a pathway inhibiting the mitochondrial complex and it is the active agent found in Graviola leaf extract to act as an inhibitor of sodium/potassium (NKA) and sarcoplasmic reticulum (SERCA) ATPase pumps[1].
价 格:¥电议型 号:T14293产 地:中国大陆
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T14273Aminooxy-PEG4-C2-Boc;化合物 T14273Aminooxy-PEG4-C2-Boc
Aminooxy-PEG4-C2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T14273产 地:中国大陆
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T14263Aminooxy-PEG3-acid;化合物 T14263Aminooxy-PEG3-acid
Aminooxy-PEG3-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T14263产 地:中国大陆
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T14253Amino-PEG9-acid;化合物 T14253Amino-PEG9-acid
Amino-PEG9-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
价 格:¥电议型 号:T14253产 地:中国大陆
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T14243Amino-PEG5-amine;化合物 T14243Amino-PEG5-amine
Amino-PEG5-amine, a PEG-based linker containing 5 units, is utilized in PROTAC synthesis.
价 格:¥电议型 号:T14243产 地:中国大陆
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T14233Amino-PEG3-C2-Amine;化合物 T14233Amino-PEG3-C2-Amine
Amino-PEG3-C2-Amine, a PEG-based linker with three units, is utilized in PROTAC synthesis.
价 格:¥电议型 号:T14233产 地:中国大陆
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T14223Amino-PEG10-amine;化合物 T14223Amino-PEG10-amine
Amino-PEG10-amine is a PEG-based PROTAC linker employed for the conjugation of two mono diethylstilbestrol (DES)-based ligands. This compound offers an alternative approach to the synthesis of highly selective and active ER antagonists, which are crucial for the advancement of endocrine therapy in breast cancer treatment[1].
价 格:¥电议型 号:T14223产 地:中国大陆
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T14213Tapotoclax;化合物 T14213AMG-176;AMG-176
AMG-176 is a MCL-1 inhibitor (Ki: 0.13 nM).
价 格:¥电议型 号:T14213产 地:中国大陆
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T14203AM-8735;化合物 T14203AM-8735
AM-8735 is an inhibitor of MDM2 ( IC50: 25 nM).
价 格:¥电议型 号:T14203产 地:中国大陆
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T14198ALX-1393;化合物ALX-1393ALX-1393
ALX-1393 is a selective GlyT2 inhibitor that effectively reduces neuronal action potential activity in a concentration-dependent manner and inhibits the activity of spontaneous networks by inducing glycinergic tetanic currents in the abdominal horn of the spinal cord. Antiinjurious effects on thermal, mechanical and chemical stimuli in rat models of acute pain.
价 格:¥电议型 号:T14198产 地:中国大陆
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T14183Alkyne-PEG4-maleimide;化合物 T14183Alkyne-PEG4-maleimide
Alkyne-PEG4-maleimide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T14183产 地:中国大陆
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T14173Ald-Ph-amido-PEG3-C2-NH2;化合物 T14173Ald-Ph-amido-PEG3-C2-NH2
Ald-Ph-amido-PEG3-C2-NH2 is a PEG-based PROTAC linker employed in PROTACs synthesis[1].
价 格:¥电议型 号:T14173产 地:中国大陆