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  • T8771Pongamol；水黄皮籽素Pongamol

    Pongamol, an identified lead molecule from the fruits of Pongamia pinnata, on glucose uptake and GLUT4 translocation in skeletal muscle cells.

    价 格：￥电议型 号：T8771产 地：中国大陆

  • T87246-Methoxydihydrosanguinarine；6-甲氧基二氢血根碱6-Methoxydihydrosanguinarine

    6-Methoxydihydrosanguinarine is a natural product. 6-Methoxydihydrosanguinarine shows strong cytotoxicity against MCF-7 and SF-268 cell lines with IC50 values of 0.61 μM and 0.54 μM, respectively.It has antibacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA) strains with minimum inhibitory concentrations (MICs) ranging from1.9 to 3.9 microg/ml

    价 格：￥电议型 号：T8724产 地：中国大陆

  • T8683Mipsagargin；化合物MipsagarginG-202；G-202

    Mipsagargin (G-202) is a new antibiotic that inhibits DNA biosynthesis.

    价 格：￥电议型 号：T8683产 地：中国大陆

  • T8560Angiotensin II human acetate血管紧张素IIAng II acetate|||DRVYIHPF acetate|||Angiotensin II acetate|||血管紧张

    Angiotensin II human acetate (DRVYIHPF acetate) is a vasoconstrictor that mainly acts on the AT1 receptor.

    价 格：￥电议型 号：T8560产 地：中国大陆

  • T8504Dianemycin；化合物DianemycinNanchangmycin (free acid)；Nanchangmycin (free acid)

    Dianemycin (Nanchangmycin (free acid)) is a broad spectrum polyether antibiotic, inhibits gram-positive bacteria. Nanchangmycin is a broad spectrum antiviral active against Zika virus

    价 格：￥电议型 号：T8504产 地：中国大陆

  • T8493Ingliforib；化合物IngliforibGPi 296|||CP 368296；GPi 296|||CP 368296

    Ingliforib (CP 368296) is a novel glycogen phosphorylase inhibitor,has antihyperglycemic and cardioprotective properties.

    价 格：￥电议型 号：T8493产 地：中国大陆

  • T8456GALNON；化合物GalnonGALNON

    Galnon is a galanin receptor agonist, improves intrinsic cortical bone tissue properties

    价 格：￥电议型 号：T8456产 地：中国大陆

  • T83978Safingol hydrochloride；沙芬戈盐酸盐SPC 100270 hydrochloride|||L-threo-dihydrosphingosine hydrochloride；SPC

    Safingol hydrochloride (L-threo-dihydrosphingosine hydrochloride) is a specific inhibitor of protein kinase C. It induces autophagy in solid tumor cells and cancer cell death by inhibiting the PKC and PI3-kinase pathways.BIIB 722 Mesylate is a selective sodium-hydrogen exchange inhibitor. Safingol hydrochloride inhibits PKC and PI3k.

    价 格：￥电议型 号：T83978产 地：中国大陆

  • T83943ING-2 AM；化合物 ING-2 AMING-2 AM

    ING-2 AM is a membrane-permeable fluorescent indicator specifically designed for sodium ions (Na+), exhibiting a binding affinity with a dissociation constant (Kd) of 20 mM. With excitation and emission maxima (λ) at 525 nm and 545 nm respectively, this compound achieves a 20-fold selectivity over potassium ions (K+). It is utilized both in vitro and in situ to monitor real-time sodium influx.

    价 格：￥电议型 号：T83943产 地：中国大陆

  • T83910S1PL-IN-31；化合物 S1PL-IN-31Sphingosine-1-Phosphate Lyase Inhibitor 31|||S1PL Inhibitor 31|||S1P Lyase

    S1PL-IN-31 is a dual-function chemical compound acting as an inhibitor of sphingosine-1-phosphate (S1P) lyase with an IC50 value of 210 nM and as an antagonist of the Smoothened (Smo) receptor with an IC50 of 440 nM. Demonstrating therapeutic potential, this compound, at a dosage of 2 mg/kg per day, effectively mitigates cervical and thoracic lymphocyte infiltration and neuromuscular weakness in rats suffering from experimental autoimmune encephalomyelitis (EAE), a condition triggered by the MOG

    价 格：￥电议型 号：T83910产 地：中国大陆

  • T83883Biotin Sphingosine；化合物 Biotin SphingosineBiotinyl Sphingosine；Biotinyl Sphingosine

    Biotin sphingosine, a biotinylated derivative of sphingosine (d18:1), serves as a probe in assays for detecting the phosphorylation activity of sphingosine kinase 1 (SPHK1) and SPHK2 in cell lysates.

    价 格：￥电议型 号：T83883产 地：中国大陆

  • T83864Plipastatin A1；化合物 Plipastatin A1SNA-60-367-3|||Fengycin IX；SNA-60-367-3|||Fengycin IX

    Plipastatin A1, a lipopeptide isolated from B. cereus, demonstrates enzyme inhibitory and immunosuppressant properties. It effectively inhibits enzymes phospholipase A2 (PLA2), phospholipase C (PLC), and phospholipase D (PLD) with half-maximal inhibitory concentrations (IC50s) of 2.9, 1.3, and 1.4 ?M, respectively. Additionally, at a concentration of 100 ?g/ml, plipastatin A1 inhibits lipopolysaccharide (LPS)-induced B cell blastogenesis and T cell blastogenesis triggered by concanavalin A. In v

    价 格：￥电议型 号：T83864产 地：中国大陆

  • T83857Soluble Epoxide Hydrolase PROTAC 1a；化合物 Soluble Epoxide Hydrolase PROTAC 1asEH Proteolysis-targeting

    Soluble epoxide hydrolase (sEH) PROTAC 1a is a proteolysis-targeting chimera (PROTAC) comprising a cereblon ligand linked to the sEH inhibitor t-TUCB via a linker, promoting selective sEH degradation and inhibiting its hydrolase activity (IC50 = 0.8 nM) significantly more than its phosphatase activity (IC50 = >10,000 nM). This compound preferentially targets cytosolic sEH for lysosomal rather than proteasomal degradation. Furthermore, it mitigates thapsigargin-induced upregulation of phosphoryla

    价 格：￥电议型 号：T83857产 地：中国大陆

  • T83841STING Agonist D61；化合物 STING Agonist D61D61|||Stimulator of Interferon Genes Agonist D61；D61|||Stimul

    STING agonist D61 is a compound that activates the stimulator of interferon genes (STING), leading to the induction of IFN3-inducible secreted alkaline phosphatase (SEAP) and IFN-β-inducible reporter genes in cellular assays, with half-maximal effective concentrations (EC50s) of 52.9 and 116 nM, respectively. At concentrations of 4, 6, and 8 ?M, D61 enhances the production of IFN-β and chemokine (C-X-C motif) ligand 10 (CXCL10) mRNA, as well as the phosphorylation of TANK-binding kinase 1 (TBK1)

    价 格：￥电议型 号：T83841产 地：中国大陆

  • T83775STING Agonist 12L；化合物 STING Agonist 12LStimulator of Interferon Genes Agonist 12L；Stimulator of Inte

    STING agonist 12L is a stimulator of interferon genes (STING) agonist that exhibits binding affinity for both wild-type STING and its variants R232, AQ, and Q with half-maximal inhibitory concentrations (IC50s) of 1.15 ?M for wild-type, 1.06 ?M for R232, 0.61 ?M for AQ, and 1.12 ?M for Q. It effectively induces reporter gene expression in THP-1 and RAW 264.7 cells, with half-maximal effective concentrations (EC50s) of 0.38 ?M and 12.94 ?M, respectively. At a concentration of 5 ?M, STING agonist

    价 格：￥电议型 号：T83775产 地：中国大陆

  • T83756S1H TFA；化合物 S1H TFASite 1-binding Helix；Site 1-binding Helix

    S1H, a synthetic peptide mimetic of human growth hormone amino acids 36-51, acts as an antagonist to the growth hormone receptor. It forms an α-helical structure in solution and inhibits STAT5 phosphorylation triggered by human growth hormone in SK-MEL-28 and MALME-3M melanoma cell lines, as well as prolactin in IM-9 B cell lymphocytes, at concentrations of 100 and 200 nM.

    价 格：￥电议型 号：T83756产 地：中国大陆

  • T83742SBP1 TFA；化合物 SBP1 TFASpike Binding Peptide 1；Spike Binding Peptide 1

    Spike Binding Peptide 1 (SBP1), representing amino acids 21-43 of angiotensin-converting enzyme 2 (ACE2), has been utilized in a novel approach involving lipid nanoparticles (LNPs) encapsulated with oseltamivir phosphate and conjugated to SBP1. This formulation aims to investigate the possibility of achieving a controlled, long-term in vivo release of oseltamivir phosphate. Furthermore, a 2% concentration of SBP1 immobilized on crosslinked networks composed of hydroxy acrylate and ethylxanthate

    价 格：￥电议型 号：T83742产 地：中国大陆

  • T83739Myr-Tat-CBD3 TFA；化合物 Myr-Tat-CBD3 TFAMyr-Tat-Calcium Channel-binding Domain 3|||N-myristate-Tat-CBD3

    Myr-Tat-CBD3 is a chemical compound that serves as an inhibitor of the protein-protein interaction between the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2). This compound effectively disrupts the Cav2.2-CRMP2 interaction by about 81% at a 10 ?M concentration and demonstrates an inhibitory concentration 50 (IC50) value of approximately 2.8 ?M against potassium-induced calcium influx in primary rat dorsal root ganglion (DRG) neurons. Furthermore, at

    价 格：￥电议型 号：T83739产 地：中国大陆

  • T83737LRRKtide TFA；化合物 LRRKtide TFAMoesin (550-564)|||Membrane-organizing Extension Spike Protein (550-564

    LRRKtide, a peptide substrate for leucine-rich repeat kinase 2 (LRRK2)—an enzyme often mutated in Parkinson´s disease patients—corresponds to amino acids 550-564 of the membrane-organizing extension spike protein (moesin). It serves to identify inhibitors of LRRK2.

    价 格：￥电议型 号：T83737产 地：中国大陆

  • T83729Tat-CIRP TFA；化合物 Tat-CIRP TFATat-Cold-inducible RNA Binding Protein；Tat-Cold-inducible RNA Binding P

    Tat-CIRP, a peptide inhibitor, impedes the protein-protein interaction between myeloid differentiation 2 (MD-2), also known as lymphocyte antigen 96 (LY96), and cold-inducible RNA binding protein (CIRP) by binding to MD-2. This disrupts the MD-2 and CIRP interaction as confirmed in co-immunoprecipitation assays. Notably, in vivo studies reveal that Tat-CIRP, at dosages of 10 and 20 mg/kg, significantly reduces infarct volume in both a mouse model of middle cerebral artery occlusion (MCAO) and a

    价 格：￥电议型 号：T83729产 地：中国大陆

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