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T83838Sp-Thymidine-5’-O-(1-thiotriphosphate) sodium；化合物 Sp-Thymidine-5’-O-(1-thiotriphosphate) sodiumSp-TT
Sp-Thymidine-5´-O-(1-thiotriphosphate) (Sp-TTP-α-S), an isomer of the sulfur-containing nucleotide derivative TTP-α-S, exhibits affinity for HIV-1 reverse transcriptase with dissociation constants (Kds) of 2.88, 4.23, and 20.21 ?M in the presence of magnesium, manganate, and cobalt, respectively. Additionally, Sp-TTP-α-S effectively inhibits the enzyme deoxynucleoside triphosphate triphosphohydrolase SAMHD1 with an inhibition constant (Ki) of 46 nM.
价 格：￥电议型 号：T83838产 地：中国大陆
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T83837Rp-Thymidine-5’-O-(1-thiotriphosphate) sodium；化合物 Rp-Thymidine-5’-O-(1-thiotriphosphate) sodiumRp-dT
Rp-Thymidine-5´-O-(1-thiotriphosphate) (Rp-TTP-α-S), an isomer of the sulfur-containing nucleotide derivative TTP-α-S, selectively interacts with HIV-1 reverse transcriptase, exhibiting dissociation constants (Kds) of 45.7, 27.32, and 39.44 ?M in the presence of magnesium, manganate, and cobalt, respectively.
价 格：￥电议型 号：T83837产 地：中国大陆
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T83834Sp-Guanosine-5’-O-(1-thiotriphosphate) sodium；化合物 Sp-Guanosine-5’-O-(1-thiotriphosphate) sodiumSp-GT
Sp-Guanosine-5´-O-(1-thiotriphosphate) (Sp-GTP-α-S), an isomer of the sulfur-containing nucleotide derivative GTP-α-S, demonstrates the ability to bind tubulin and facilitate microtubule assembly in cell-free assays at a concentration of 20 mM.
价 格：￥电议型 号：T83834产 地：中国大陆
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T83833Rp-2’-Deoxyuridine-5’-O-(1-thiotriphosphate) sodium；化合物 Rp-2’-Deoxyuridine-5’-O-(1-thiotriphosphate)
Rp-2´-Deoxyuridine-5´-O-(1-thiotriphosphate) (Rp-dUTP-α-S), a sulfur-containing nucleotide isomer and purinergic P2Y2 receptor agonist, preferentially promotes inositol phosphate accumulation in 1321N1 astrocytoma cells with P2Y2 receptors (EC50 = 12.5 ?M) compared to those expressing P2Y4 receptors at a concentration of 10 ?M.
价 格：￥电议型 号：T83833产 地：中国大陆
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T83831Sp-2’-Deoxyguanosine-5’-O-(1-thiotriphosphate) sodium；化合物 Sp-2’-Deoxyguanosine-5’-O-(1-thiotriphosph
Sp-2´-Deoxyguanosine-5´-O-(1-thiotriphosphate), a sulfur-containing isomer of 2´-deoxyguanosine-5´-O-triphosphate (dGTP), functions as an inhibitor of the deoxynucleoside triphosphate triphosphohydrolase SAMHD1, with an inhibitory constant (Ki) of 820 nM.
价 格：￥电议型 号：T83831产 地：中国大陆
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T838292’-Deoxy-1,N6-ethenoadenosine-5’-O-triphosphate sodium；化合物 2’-Deoxy-1,N6-ethenoadenosine-5’-O-tripho
2´-Deoxy-1,N6-ethenoadenosine-5´-O-triphosphate (ε-dATP), a fluorescent derivative of 2’-deoxyadenosine-5’-O-triphosphate (dATP), promotes sister chromatid exchange in stimulated primary mouse spleen T- and B lymphocytes with LPS or concanavalin A at concentrations of 50 to 150 ?M. Utilized in ambiguous base pairing investigations within vinyl chloride-induced mutagenesis research, ε-dATP, along with its related compound ε-ATP—which exhibits an emission peak at 415 nm after being exc
价 格：￥电议型 号：T83829产 地：中国大陆
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T83828Sp-2’-Deoxycytidine-5’-O-(1-thiotriphosphate) sodium；化合物 Sp-2’-Deoxycytidine-5’-O-(1-thiotriphosphat
Sp-2´-Deoxycytidine-5´-O-(1-thiotriphosphate) (Sp-dCTP-α-S), an isomer of the sulfur-containing nucleotide derivative dCTP-α-S, functions as an inhibitor of the deoxynucleoside triphosphate triphosphohydrolase SAMHD1, with an inhibition constant (Ki) of 6.3 ?M.
价 格：￥电议型 号：T83828产 地：中国大陆
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T83823Sp-Uridine-5’-O-(1-thiotriphosphate) sodium；化合物 Sp-Uridine-5’-O-(1-thiotriphosphate) sodiumSp-UTP-α-
Sp-Uridine-5´-O-(1-thiotriphosphate) (Sp-UTP-α-S) acts as a nucleotide agonist for purinergic Y2 (P2Y2) and P2Y4 receptors, efficiently inducing inositol phosphate accumulation in 1321N1 astrocytoma cells that express these receptors, with half-maximal effective concentrations (EC50s) of 14 ?M and 81 ?M, respectively.
价 格：￥电议型 号：T83823产 地：中国大陆
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T83822Rp-Uridine-5’-O-(1-thiotriphosphate) sodium；化合物 Rp-Uridine-5’-O-(1-thiotriphosphate) sodiumRp-UTP-α-
Rp-Uridine-5´-O-(1-thiotriphosphate) (Rp-UTP-α-S) serves as a nucleotide agonist for purinergic P2Y2 and P2Y4 receptors, effectively inducing inositol phosphate accumulation within 1321N1 astrocytoma cells that express either P2Y2 or P2Y4 receptors, with EC50 values of 5.4 and 27 ?M, respectively.
价 格：￥电议型 号：T83822产 地：中国大陆
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T83818Isoguanosine-5’-O-triphosphate sodium；化合物 Isoguanosine-5’-O-triphosphate sodium2-Hydroxyadenosine 5’
Isoguanosine-5´-O-triphosphate, an isomer of guanosine 5´-triphosphate (GTP) and a phosphorylated derivative of crotonoside, does not promote microtubule assembly like GTP. At a concentration of 2 mM, it hampers transcription and triggers T to C mutations in reverse transcriptase assays. This compound aids in assessing the substrate specificity of both phosphofructokinase and mutT homolog 1 (MTH1).
价 格：￥电议型 号：T83818产 地：中国大陆
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T83817Isoguanosine-5’-O-diphosphate sodium；化合物 Isoguanosine-5’-O-diphosphate sodiumisoGDP；isoGDP
Isoguanosine-5´-O-diphosphate (isoGDP), an isomer of GDP and a phosphorylated variant of crotonoside, acts as a mitochondrial ATPase inhibitor, demonstrating effectiveness at a concentration of 3 ?M (IC50 = 3 ?M).
价 格：￥电议型 号：T83817产 地：中国大陆
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T83816Cytidine-5’-O-(2-thiodiphosphate) sodium；化合物 Cytidine-5’-O-(2-thiodiphosphate) sodiumCDP-β-S；CDP-β-S
Cytidine-5’-O-(2-thiodiphosphate) (CDP-β-S), a non-hydrolyzable derivative of CDP exhibiting antioxidant activity, effectively scavenges free radicals as evidenced by its performance in the Trolox equivalent absorbance capacity (TEAC) assay at concentrations between 5 and 20 ?M.
价 格：￥电议型 号：T83816产 地：中国大陆
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T838156-Chloropurine riboside-5’-triphosphate sodium；化合物 6-Chloropurine riboside-5’-triphosphate sodium6-c
6-Chloropurine riboside-5´-triphosphate serves as both an inhibitor and an activator in biochemical processes. It inhibits the RNA triphosphatase mRNA-capping enzyme subunit β (Cet1; IC50 = 2 ?M for the GTPase activity of the S. cerevisiae enzyme), proving its efficacy against the enzyme responsible for the capping of mRNA molecules. Additionally, it acts as a phosphorylated derivative of 6-chloropurine riboside. This compound also activates the E. coli enzyme aspartate carbamoyltransferas
价 格：￥电议型 号：T83815产 地：中国大陆
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T838148-Bromoguanosine-5’-O-triphosphate sodium；化合物 8-Bromoguanosine-5’-O-triphosphate sodium8-bromo GTP；8
8-Bromoguanosine-5´-O-triphosphate, a derivative of guanosine 5´-triphosphate (GTP) - the energy substrate for protein synthesis and gluconeogenesis, acts as an inhibitor of the E. coli GTPase FtsZ with an inhibition constant (Ki) of 31.8 ?M. Furthermore, at a concentration of 500 ?M, it facilitates the assembly of porcine brain microtubules in a cell-free assay.
价 格：￥电议型 号：T83814产 地：中国大陆
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T83808Sp-Adenosine-5’-O-(1-thiotriphosphate) sodium；化合物 Sp-Adenosine-5’-O-(1-thiotriphosphate) sodiumSp-AT
Sp-Adenosine-5´-O-(1-thiotriphosphate) (Sp-ATP-α-S), an isomer of the ATP-α-S sulfur-containing nucleotide derivative and a purinergic P2Y1 receptor agonist, effectively increases calcium mobilization in HEK293 cells harboring the P2Y1 receptor with an EC50 of 9.4 nM for the human receptor. It also inhibits ADP-induced human isolated platelet aggregation with a Ki value of 4 μM and prompts relaxation in carbamoylcholine-tightened guinea pig taenia coli, achieving an EC50 of 426 nM.
价 格：￥电议型 号：T83808产 地：中国大陆
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T83807Rp-Adenosine-5’-O-(1-thiotriphosphate) sodium；化合物 Rp-Adenosine-5’-O-(1-thiotriphosphate) sodiumRp-AT
Rp-Adenosine-5´-O-(1-thiotriphosphate) (Rp-ATP-α-S), a sulfur-containing nucleotide derivative isomer and a purinergic P2Y1 receptor agonist, promotes calcium mobilization in HEK293 cells expressing the human P2Y1 receptor (EC50 = 75 nM). This compound exhibits binding affinity to washed isolated human platelets (Ki = 156 nM) and attenuates ADP-induced aggregation in human platelet-rich plasma (PRP; pA2 = 4.74), as well as inhibits cAMP production triggered by prostaglandin E1 (PGE1) in hu
价 格：￥电议型 号：T83807产 地：中国大陆
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T83806Sp-Adenosine-5’-O-(1-thiodiphosphate) sodium；化合物 Sp-Adenosine-5’-O-(1-thiodiphosphate) sodiumSp-ADP-
Sp-Adenosine-5’-O-(1-thiodiphosphate) (Sp-ADP-α-S), an isomer of the sulfur-containing nucleotide derivative ADP-α-S, functions as an inhibitor of phosphorylase kinase with an inhibition constant (Ki) of 0.53 ?M. This compound also promotes aggregation of isolated human platelets with an effective concentration (EC50) of 20 ?M and induces relaxation in carbamoylcholine-precontracted guinea pig taenia coli with an EC50 of 58.9 ?M.
价 格：￥电议型 号：T83806产 地：中国大陆
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T83805Rp-Adenosine-5’-O-(1-thiodiphosphate) sodium；化合物 Rp-Adenosine-5’-O-(1-thiodiphosphate) sodiumRp-ADP-
Rp-Adenosine-5´-O-(1-thiodiphosphate) (Rp-ADP-α-S), a sulfur-containing isomer of the nucleotide derivative ADP-α-S, acts as an inhibitor of phosphorylase kinase with an inhibition constant (Ki) of 0.53 ?M. This compound also induces aggregation in isolated human platelets with an effective concentration (EC50) of 20 ?M and promotes relaxation in guinea pig taenia coli that has been precontracted with carbamoylcholine, with an EC50 of 58.9 ?M.
价 格：￥电议型 号：T83805产 地：中国大陆
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T837897-Deazaadenosine-5’-O-diphosphate sodium；化合物 7-Deazaadenosine-5’-O-diphosphate sodium7-CH-ADP|||Tube
7-Deazaadenosine-5´-O-diphosphate, a modified nucleotide and metabolite of tubercidin, is generated through phosphorylation of tubercidin and further undergoes phosphorylation to become the active metabolite 7-deazaadenosine-5´-O-triphosphate.
价 格：￥电议型 号：T83789产 地：中国大陆
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T837868-Chloroadenosine-5’-triphosphate sodium；化合物 8-Chloroadenosine-5’-triphosphate sodium8-chloro ATP；8-
8-Chloroadenosine-5’-triphosphate (8-chloro ATP), a potent metabolite of the anticancer agent 8-chloro cyclic AMP (cAMP) and a nucleotide derivative, is produced through the biotransformation of 8-chloro cAMP into 8-chloroadenosine, followed by mono- and diphosphate intermediates. Accumulating for up to 12 hours after the administration of 8-chloro cAMP or 8-chloroadenosine, 8-chloro ATP inhibits cell growth, diminishes endogenous ATP levels, and reduces RNA synthesis without affecting DNA synth
价 格：￥电议型 号：T83786产 地：中国大陆
