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T6272Fosbretabulin DisodiumFosbretabulin Disodium,CA 4P,Combretastatin A4 disodium phosphate
Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium, a water-soluble prodrug of Combretastatin A4 (CA4), is a microtubule-targeting agent that binds β-tubulin (Kd: 0.4 μM). Fosbretabulin Disodium inhibits the polymerization of tubulin (IC50: 2.4 μ
价 格:¥电议型 号:T6272产 地:美洲
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T8476RSVA405;化合物RSVA 405RSVA 405;RSVA 405
RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor
价 格:¥电议型 号:T8476产 地:中国大陆
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T83847SP-A (196-215) (human) TFA;化合物 SP-A (196-215) (human) TFASurfactant Protein A|||SPA4;Surfactant Prot
Surfactant protein A (SP-A) (196-215) is a synthetic peptide derived from the C-terminal carbohydrate recognition domain of human SP-A, specifically amino acids 196-215. This peptide suppresses LPS-induced TNF-α release in JAWSII mouse dendritic cells at 1 and 10 ?M concentrations and promotes phagocytosis of P. aeruginosa at a 75 ?M concentration. Furthermore, intratracheal administration of SP-A (196-215) at a dose of 50 ?g per animal reduces disease severity and lung colony-forming units in m
价 格:¥电议型 号:T83847产 地:中国大陆
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T833324,27-Dimethyl withaferin A;化合物 4,27-Dimethyl withaferin A4,27-Dimethyl withaferin A
4,27-Dimethyl withaferin A, a synthetic analog of withanolide natural products, exhibits potential in the study of neurodegenerative diseases[1].
价 格:¥电议型 号:T83332产 地:中国大陆
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T833194-epi-Withaferin A;化合物 4-epi-Withaferin A4-epi-Withaferin A
4-epi-Withaferin A (compound 28), an analogue of Withaferin A, exhibits enhanced cytotoxicity and cytoprotective heat-shock-inducing activity (HSA). It shows promise for the investigation of protein aggregation-associated diseases through the stimulation of cellular defense mechanisms [1].
价 格:¥电议型 号:T83319产 地:中国大陆
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T833164-Methyl withaferin A;化合物 4-Methyl withaferin A4-Methyl withaferin A
4-Methylwithaferin A, a withaferin A analog, exhibits antitumor activity [1].
价 格:¥电议型 号:T83316产 地:中国大陆
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T83225A4333;化合物 A4333A4333
A4333, a biotinylated derivative of A3373, selectively inhibits Phospholipase D1 (PLD1) while sparing PLD2. It is noted for its significant role in antitumor activity [1].
价 格:¥电议型 号:T83225产 地:中国大陆
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T81574PAA4;化合物 PAA4PAA4
PAA4, a methide carbon-centered polynuclear Au(I) cluster, exhibits antiproliferative activity and induces pH2AX expression in a time-dependent manner. It also demonstrates an anti-tumor effect in an orthotopic bladder cancer mouse model [1].
价 格:¥电议型 号:T81574产 地:中国大陆
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T81534PDE11A4-IN-1;化合物 PDE11A4-IN-1PDE11A4-IN-1
PDE11A4-IN-1 (compound 23b) is a potent, selective inhibitor of PDE11A4, demonstrating an IC50 of 12 nM and exhibiting high selectivity against PDE1, PDE2, PDE7, PDE8, and PDE9 [1].
价 格:¥电议型 号:T81534产 地:中国大陆
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T81149SMA4;化合物 SMA4SMA4
SMA4, a selective activator of PKG1α, exhibits a basal EC50 of 29 μM, enhances phosphorylation of the PKG1 substrate VASP, and inhibits proliferation of hPASMCs. It is utilized in cardiovascular disease research [1].
价 格:¥电议型 号:T81149产 地:中国大陆
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T79343hCYP3A4-IN-1;化合物 hCYP3A4-IN-1hCYP3A4-IN-1
hCYP3A4-IN-1 (compound C6) is a potent, orally active inhibitor of hCYP3A4, exhibiting IC50 values of 43.93 nM in human liver microsomes (HLMs) and 153.00 nM in the CHO-3A4 stably transfected cell line. It competitively inhibits the CYP3A4-mediated hydroxylation of N-ethyl-1,8-naphthalimide (NEN) with a Ki of 30.00 nM [1].
价 格:¥电议型 号:T79343产 地:中国大陆
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T78808NDNA4;化合物 NDNA4NDNA4
NDNA4 (compound 17) is a selective Hsp90α inhibitor (IC50: 0.34 μM), characterized by its permanent charge and low membrane permeability. It exhibits minimal cytotoxicity against Ovcar-8 and MCF-10A cell lines (IC50 >100 μM) and maintains hERG channel maturation without eliciting a heat shock response or degrading Hsp90α-dependent client proteins [1].
价 格:¥电议型 号:T78808产 地:中国大陆
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T78334Surzebiclimab;化合物 SurzebiclimabBGB-A425;BGB-A425
Surzebiclimab (BGB-A425), a humanized variant IgG1 monoclonal antibody, targets and binds with high affinity (K D = 0.36 nM) and specificity to the extracellular domain of T-cell immunoglobulin and mucin-domain containing-3 (TIM-3). This compound is utilized in cancer research [1].
价 格:¥电议型 号:T78334产 地:中国大陆
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T77698hCYP3A4 Fluorogenic substrate 1;化合物 hCYP3A4 Fluorogenic substrate 1hCYP3A4 Fluorogenic substrate 1
hCYP3A4 Fluorogenic substrate 1 is a phthalimide derivative and shows low activity against COX.
价 格:¥电议型 号:T77698产 地:中国大陆
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T76447[DAla4] Substance P (4-11);化合物 [DAla4] Substance P (4-11)[DAla4] Substance P (4-11)
[DAla4] Substance P (4-11), an analog of Substance P (Substance P), effectively inhibits the binding of 125I-Bolton Hunter-conjugated Eledoisin (Eledoisin) and 125I-Bolton Hunter-conjugated Substance P to rat brain cortex membranes, with IC50 values of 0.5 μM and 0.15 μM, respectively [1].
价 格:¥电议型 号:T76447产 地:中国大陆
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T75933d[Cha4]-AVP TFA;化合物 d[Cha4]-AVP TFAd[Cha4]-AVP TFA
d[Cha4]-AVP TFA is a potent and selective agonist for the vasopressin (AVP) V1b receptor, displaying a high affinity with a K i of 1.2 nM. It exhibits greater selectivity for the V1b receptor over the V1a receptor, V2 receptor, and oxytocin receptors, demonstrating its specificity in targeting the human V1b receptor [1] [2].
价 格:¥电议型 号:T75933产 地:中国大陆
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T72900Indolokine A4;化合物 Indolokine A4Indolokine A4
Indolokine A4, a catabolite of indole-3-pyruvate (I3P), is a potent AhR agonist [1] .
价 格:¥电议型 号:T72900产 地:中国大陆
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T71854AA43279;化合物 AA43279AA43279
AA43279 is a novel selective Nav1.1 activator, increasing the firing activity of parvalbumin-expressing, fast-spiking GABAergic interneurons and increasing the spontaneous inhibitory post-synaptic currents (sIPSCs) recorded from pyramidal neurons.
价 格:¥电议型 号:T71854产 地:中国大陆
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T69933VA4 TG2 inhibitor;化合物 VA4 TG2 inhibitorVA4 TG2 inhibitor
VA4 is a novel irreversible TG2 transamidase site-specific inhibitor.
价 格:¥电议型 号:T69933产 地:中国大陆
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T68316GAC0003A4;化合物 GAC0001E5GAC0001E5;GAC0001E5
GAC0003A4 is a potent LXR inverse agonist with antitumor activity that inhibits the transcription of LXR proteins.GAC0003A4 degrades LXRβ proteins and inhibits the proliferation of PDAC cells in a dose-dependent manner.GAC0003A4 has been used in the study of advanced pancreatic cancers and other recalcitrant malignancies.
价 格:¥电议型 号:T68316产 地:中国大陆