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T40849C20 Ceramide；C20神经酰胺N-Arachidoyl-D-sphingosine；N-Arachidoyl-D-sphingosine
C20 Ceramide (N-Arachidoyl-D-sphingosine) is a 20:0 ceramide found in the brain that crosses the blood-brain barrier to activate microglia and induce depressive-like behavior.
价 格：￥电议型 号：T40849产 地：中国大陆
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T4013SGC2085 HCl；化合物SGC2085 HClSGC2085 HCl
SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivity over other PRMTs. CARM1 is an important positive modulator of Wnt/β-catenin transcription and neoplastic transformation in colorectal cancer as well as a critical factor in estrogen-stimulated breast cancer growth, and its depletion results in decreased proliferation of myeloid leukemia cells in vivo.
价 格：￥电议型 号：T4013产 地：中国大陆
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T39474UNC2025 hydrochlorideUNC2025 hydrochlorideUNC2025 hydrochloride
UNC2025 hydrochloride is a potent, ATP-competitive, highly orally active Mer/Flt3 inhibitor. It has IC50 values of 0.74 nM and 0.8 nM, respectively, for Mer and Flt3. UNC2025 hydrochloride demonstrates over 45-fold selectivity for MERTK compared to Axl (IC50 = 122 nM; Ki = 13.3 nM). Additionally, UNC2025 hydrochloride exhibits excellent PK properties, making it suitable for investigating acute leukemia.
价 格：￥电议型 号：T39474产 地：中国大陆
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T37428TRPC6-PAM-C20；化合物TRPC6-PAM-C20TRPC6-PAM-C20|||3-(6,7-Dimethoxy-3,3-dimethyl-3,4-dihydro-isoquinolin-
TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator. TRPC6-PAM-C20 induces transient increase in intracellular Ca2+ in HEK cells expressing TRPC6 with an EC50 of 2.37 μM. TRPC6-PAM-C20 enhances OAG-induced platelet aggregation.
价 格：￥电议型 号：T37428产 地：中国大陆
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T37407Arachidonoyl-L-carnitine (chloride)；Arachidonoyl-L-carnitine (chloride)C20:4 Carnitine?|||Arachidono
Carnitine facilitates the transport of fatty acids into the mitochondria to be used in fatty acid metabolism. It does so by accepting acyl groups from fatty acids complexed with coenzyme A, which yields esterified carnitine or acylcarnitines that enable the transport of fatty acyl groups into the inner mitochondrial matrix. β-Oxidation of fatty acids in mitochondria is inhibited by uncoupling conditions, thus changes in circulating levels of various acylcarnitines have been used to identify alte
价 格：￥电议型 号：T37407产 地：中国大陆
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T35809C20 Sphingomyelin (d18:1/20:0)；C20 Sphingomyelin (d18:1/20:0)C20 Sphingomyelin (d18:1/20:0)
C20 Sphingomyelin is a naturally occurring sphingolipid. Levels of C20 sphingomyelin are upregulated in the hippocampus of rats with diabetes induced by streptozotocin and in human plasma where it is positively correlated with insulin resistance in obese humans. C20 sphingomyelin is also upregulated in the liver of a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder. The plasma concentration of C20 sphingomyelin is decreased in m
价 格：￥电议型 号：T35809产 地：中国大陆
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T35778Ochratoxin A-13C20；Ochratoxin A-13C20Ochratoxin A-13C20；Ochratoxin A-13C20
Ochratoxin A-13C20is intended for use as an internal standard for the quantification of ochratoxin A by GC- or LC-MS. Ochratoxin A is a mycotoxin that has been found inAspergillusandPenicillium.1It increases lipid peroxide levels and the number of apoptotic cells, as well as reduces superoxide dismutase activity in rat kidney when administered at a dose of 120 μg/kg.2Topical application of ochratoxin A (80 μg/mouse) induces DNA damage, cell cycle arrest at the G0/G1phase, and apoptosis in mouse
价 格：￥电议型 号：T35778产 地：中国大陆
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T3511PF-1355；化合物PF-1355PF-06281355|||PF 06281355|||ZINC205721785；PF-06281355|||PF 06281355|||ZINC20572178
PF-1355 (PF 06281355) is a selective 2-thiouracil mechanism-based MPO inhibitor. PF-1355 is used for treatment of vasculitic diseases.
价 格：￥电议型 号：T3511产 地：中国大陆
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T33514MSC 2032964A；化合物MSC 2032964AMSC-2032964A|||MSC2032964A；MSC-2032964A|||MSC2032964A
MSC 2032964A is a potent selective ASK1 inhibitor (IC50 = 93 nM) that is oral bioavailable and brain permeable. It inhibited neuroinflammation in mouse EAE models and blocked LPS-induced phosphorylation of ASK1 and p38 in cultured mouse astrocytes.
价 格：￥电议型 号：T33514产 地：中国大陆
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T31969Glycyldehydroalanine；化合物 T31969NSC 203458|||NSC-203458|||NSC203458；NSC 203458|||NSC-203458|||NSC2034
Glycyldehydroalanine is a biochemical.
价 格：￥电议型 号：T31969产 地：中国大陆
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T30852CGP-75254A；化合物 T30852CGP 75254A|||UNII-94KC20I6YX|||CGP75254A；CGP 75254A|||UNII-94KC20I6YX|||CGP7525
CGP-75254A is a novel oral iron chelator.
价 格：￥电议型 号：T30852产 地：中国大陆
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T293101-Phenyl-2-nitropropene；化合物 T29310NSC-2014|||NSC2014|||NSC 2014；NSC-2014|||NSC2014|||NSC 2014
1-Phenyl-2-nitropropene is a biochemical.
价 格：￥电议型 号：T29310产 地：中国大陆
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T28697SC-2001；化合物 T28697SC2001；SC2001
SC-2001 is a MCL-1 inhibitor. SC-2001 inhibits STAT3 phosphorylation through enhancing SHP-1 expression and induces apoptosis in human breast cancer cells. SC-2001 overcomes STAT3-mediated sorafenib resistance through RFX-1/SHP-1 activation in hepatocellular carcinoma.
价 格：￥电议型 号：T28697产 地：中国大陆
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T28509RDR03871；化合物RDR03871RDR 03871|||ZINC20458540|||RDR-03871；RDR 03871|||ZINC20458540|||RDR-03871
RDR03871 is an MDM2 inhibitor.
价 格：￥电议型 号：T28509产 地：中国大陆
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T2640Rebastinib；化合物DCC-2036DCC2036|||DCC 2036|||DCC-2036；DCC2036|||DCC 2036|||DCC-2036
DCC-2036 (Rebastinib (DCC-2036)) is a conformational control Bcr-Abl inhibitor for Abl1(WT, IC50: 0.8 nM) and Abl1(T315I, IC50: 4 nM), also inhibits LYN, SRC, HCK, FGR, FLT3, KDR, and Tie-2, and low activity to c-Kit. Rebastinib aimed at the Angiopoietin2-Tie2 pathway.
价 格：￥电议型 号：T2640产 地：中国大陆
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T2585Bedaquiline；贝达喹啉R207910|||TMC207；R207910|||TMC207|||贝达喹啉
Bedaquiline (R207910) is an anti-tuberculosis drug which selectively inhibit the mycobacterial energy metabolism i.e. ATP synthesis and found to be effective against all states of Mycobacterium tuberculosis.
价 格：￥电议型 号：T2585产 地：中国大陆
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T24768SC-203885；化合物 T24768SC 203885|||SC203885；SC 203885|||SC203885
SC-203885 is a checkpoint kinase 2 inhibitor.
价 格：￥电议型 号：T24768产 地：中国大陆
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T24705Ramentaceone；化合物 T24705NSC-208733|||NSC 624625|||NSC 208733|||NSC208733|||NSC-624625；NSC-208733|||NS
Ramentaceone is an antineoplastic.
价 格：￥电议型 号：T24705产 地：中国大陆
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T2345PTC-209；化合物PTC-209PTC209|||PTC 209；PTC209|||PTC 209
PTC-209 is a potent and selective BMI-1 inhibitor.
价 格：￥电议型 号：T2345产 地：中国大陆
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T2234TCS JNK 5a；化合物SC202671SC202671|||SC 202671|||N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-na
TCS JNK 5a (SC202671) is an effective, specific inhibitor of JNK3(pIC50= 6.7), JNK2(pIC50=6.5).
价 格：￥电议型 号：T2234产 地：中国大陆
