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  • T37454C16 dihydro Ceramide (d18:0/16:0)；C16 dihydro Ceramide (d18:0/16:0)Ceramide (d18:0/16:0)|||Cer(d18:0

    C16 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C16 ceramide (d18:0/16:0) that lacks the 4,5-trans double bond.[1] C16 dihydro Ceramide (0-46 nM) inhibits C16 ceramide-induced membrane permeabilization, measured as cytochrome C oxidation, in rat liver mitochondria in a concentration-dependent manner. It also inhibits C16 ceramide-induced channel formation in liposomes. C16 dihydro ceramide is biologically inactive as a single agent, lacking the ability

    价 格：￥电议型 号：T37454产 地：中国大陆

  • T37440C2 Adamantanyl Galactosylceramide (d18:1/2:0)；C2 Adamantanyl Galactosylceramide (d18:1/2:0)C2 Adaman

    C2 Adamantanyl Galactosylceramide (d18:1/2:0) (AdaGalCer) is a bioactive sphingolipid. It reduces globotriaosylceramide 3 synthesis from exogenous lactosylceramide in microsomes. AdaGalCer stimulates recombinant glucocerebrosidase activity in a pH-dependent manner. It activates glucocerebrosidase to decrease glucosylceramide accumulation in fibroblasts and lymphoblasts isolated from patients with Gaucher and Fabry disease, respectively.

    价 格：￥电议型 号：T37440产 地：中国大陆

  • T37439C18 Globotriaosylceramide (d18:1/18:0)；C18 Globotriaosylceramide (d18:1/18:0)C18 Globotriaosylcerami

    C18 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from lactosylceramide . It inhibits aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate (PMA; 10008014) when used at a concentration of 1 μM. C18 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry disease, a lysosoma

    价 格：￥电议型 号：T37439产 地：中国大陆

  • T37438C17 Globotriaosylceramide (d18:1/17:0)；C17 Globotriaosylceramide (d18:1/17:0)C17 Globotriaosylcerami

    C17 Globotriaosylceramide is a sphingolipid that has been used as an internal standard for the quantification of globotriaosylceramides in plasma and urine from patients with Fabry disease by GC-MS.

    价 格：￥电议型 号：T37438产 地：中国大陆

  • T37437C17 Ceramide (d18:1/17:0)；C17 Ceramide (d18:1/17:0)C17 Ceramide (d18:1/17:0)

    C17 Ceramide is a synthetic ceramide that contains a non-natural C17:0 fatty acid acylated to sphingosine. It has been used as a marker of arylsulfatase A and sphingolipid activator B activity in patients undergoing enzyme replacement therapy for the genetic disease metachromatic leukodystrophy.

    价 格：￥电议型 号：T37437产 地：中国大陆

  • T37436C12-Ceramide；化合物 C12-CeramideN-Laurylsphingosine|||C12 Ceramide (d18:1/12:0)|||N-Lauroyl-D-erythro-s

    C12-Ceramide (C12 Ceramide (d18:1/12:0)), a ceramide present in the protective membranes surrounding umbilical cord blood vessels in infants born to women with pre-eclampsia, can be used to assess the level of ASM activity in the plasma of patients with Niemann-Pick disease.

    价 格：￥电议型 号：T37436产 地：中国大陆

  • T37291Lyso-Globotriaosylceramide (d18:1)；Lyso-Globotriaosylceramide (d18:1)Lyso-Globotriaosylceramide (d18

    Lyso-globotriaosylceramide is a form of globotriaosylceramide that is lacking the fatty acyl group. It binds to Shiga toxin 1 (Stx1) in the presence of cholesterol and phosphatidylcholine but does not bind Stx2. It also reduces viability and aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate when used at concentrations of 50 and 1 μM, respectively. Lyso-globotriaosylceramide accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry diseas

    价 格：￥电议型 号：T37291产 地：中国大陆

  • T36859C16 Globotriaosylceramide (d18:1/16:0)；C16 Globotriaosylceramide (d18:1/16:0)C16 Globotriaosylcerami

    C16 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from C16 lactosylceramide . C16 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease. C16 globotriaosylceramide is also upregulated in plasma of patien

    价 格：￥电议型 号：T36859产 地：中国大陆

  • T36858C12 Galactosylceramide (d18:1/12:0)；C12 Galactosylceramide (d18:1/12:0)C12 Galactosylceramide (d18:1

    C12 Galactosylceramide is a bioactive sphingolipid. It inhibits IL-4 production by 53.84% in EL4 T cells when used at a concentration of 10 μM. C12 Galactosylceramide reduces the growth of human papillomavirus type 16-associated tumors in mice and reduces tumor recurrence following surgical removal or chemotherapy. It also reduces natural killer T cell activity, delays the onset of proteinuria, and improves survival in a mouse model of systemic lupus.

    价 格：￥电议型 号：T36858产 地：中国大陆

  • T36671C2 Phytoceramide (t18:0/2:0)；C2 Phytoceramide (t18:0/2:0)C2 Phytoceramide (t18:0/2:0)

    C2 Phytoceramide is a bioactive semisynthetic sphingolipid that inhibits formyl peptide-induced oxidant release (IC50 = 0.38 μM) in suspended polymorphonuclear cells. It increases COX-2 protein levels 15-fold through ERK signaling. It induces death of keratinocytes (20% viability) with an ED50 value of 30 μM, the same concentration at which 35% of cells in a TUNEL assay are apoptotic. C2 Phytoceramide also has antiproliferative effects in CHO cells, with greater than 80% cytotoxicity achieved at

    价 格：￥电议型 号：T36671产 地：中国大陆

  • T36324C8 L-threo Ceramide (d18:1/8:0)；C8 L-threo Ceramide (d18:1/8:0)C8 L-threo Ceramide (d18:1/8:0)；C8 L-

    C8 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 10 μM) and, like C8 D-threo ceramide , induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 L-erythro ceramide . C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein release, with a 50% release dose (RD50) value of ~30 μg/ml.

    价 格：￥电议型 号：T36324产 地：中国大陆

  • T36323C8 Galactosylceramide (d18:1/8:0)；C8 Galactosylceramide (d18:1/8:0)C8 Galactosylceramide (d18:1/8:0)

    C8 Galactosylceramide is a synthetic C8 short-chain derivative of known membrane microdomain-forming sphingolipids. It increases the amount delivered and toxicity of doxorubicin in cancerous but not non-cancerous cells when incorporated into the nanoliposomal membrane of nanoliposomal-doxorubicin. C8 Galactosylceramide induces proliferation and cytokine production by splenocytes in vitro at concentrations ranging from 100-1,000 ng/ml but has no effect on natural killer T cell production in vivo.

    价 格：￥电议型 号：T36323产 地：中国大陆

  • T36322C8 D-threo Ceramide (d18:1/8:0)；C8 D-threo Ceramide (d18:1/8:0)C8 D-threo Ceramide (d18:1/8:0)；C8 D-

    C8 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 17 μM) and induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 ceramide . C8 D-threo Ceramide is a substrate for E. coli diacylglycerol kinase. It activates ceramide-activated protein kinase (CAPK) in U937 cells. C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein r

    价 格：￥电议型 号：T36322产 地：中国大陆

  • T36321C6 Urea CeramideC6 Urea CeramideC6 Urea Ceramide|||C-6 Urea Ceramide

    C6 urea ceramide is an inhibitor of neutral ceramidase.1 It increases total ceramide levels in wild-type mouse embryonic fibroblasts (MEFs) and in HT-29 colon cancer cells but not in MEFs lacking neutral ceramidase. It inhibits proliferation of, and induces apoptosis and autophagy in HT-29, but not non-cancerous RIE-1, cells when used at concentrations of 5 and 10 μM. C6 urea ceramide decreases total β-catenin, increases phosphorylated β-catenin, and induces colocalization of β-catenin with the

    价 格：￥电议型 号：T36321产 地：中国大陆

  • T36320C6 L-threo Ceramide (d18:1/6:0)；C6 L-threo Ceramide (d18:1/6:0)C6 L-threo Ceramide (d18:1/6:0)；C6 L-

    C6 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 L-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM). It is metabolically inactive and, unlike C6 L-erythro ceramide , C6 L-threo ceramide cannot be converted to C6 glucosylceramide by ceramide glucosyltransferase. C6 L-threo Ceramide enhances IL-4 production induced by phorbol 12-myristate 13-acetate in EL4 T cells when used at a concentration of 10 μM.

    价 格：￥电议型 号：T36320产 地：中国大陆

  • T36319C6 L-erythro Ceramide (d18:1/6:0)；C6 L-erythro Ceramide (d18:1/6:0)C6 L-erythro Ceramide (d18:1/6:0)

    C6 L-erythro Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is metabolized by ceramide glucosyltransferase to form C6 L-erythro glucosylceramide. C6 L-erythro Ceramide is cytotoxic to U937 cells (IC50 = 18 μM).

    价 格：￥电议型 号：T36319产 地：中国大陆

  • T36230C2 Ceramide (d14:1/2:0)；C2 Ceramide (d14:1/2:0)C2 Ceramide (d14:1/2:0)；C2 Ceramide (d14:1/2:0)

    C2 Ceramide (d14:1/2:0) is a bioactive sphingolipid. Dietary administration of C2 ceramide (d14:1/2:0) (100 μM) induces lipotoxic cardiomyopathy via increasing diastolic and systolic diameter as well as reducing fractional shortening and the number of normal cardiac contractile events in Drosophila.

    价 格：￥电议型 号：T36230产 地：中国大陆

  • T36188Ceramide Phosphoethanolamines (bovine)；Ceramide Phosphoethanolamines (bovine)Ceramide Phosphoethanol

    Ceramide phosphoethanolamine (CPE) is an analog of sphingomyelin that contains ethanolamine rather than choline as the head group. It is the principal membrane phospholipid in invertebrates such as Drosophila, which lacks sphingomyelin. It is only produced in small amounts in mammalian cells, accounting for approximately 0.02 mol% of total phospholipids in mouse testis and brain. In Drosophila, CPE is biosynthesized by CPE synthase from ceramide and cytidine diphosphate-ethanolamine in the Golgi

    价 格：￥电议型 号：T36188产 地：中国大陆

  • T36186Globotriaosylceramides (porcine)；Globotriaosylceramides (porcine)Globotriaosylceramides (porcine)

    Globotriaosycleramides are glycosphingolipids found in mammalian cell membranes that are synthesized from lactosylceramides . They act as receptors for Shiga and Shiga-like toxins in vitro and in vivo. Globotriaosylceramides accumulate in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease, a lysosomal storage disorder characterized by a deficiency in the enzyme α-galactosidase A. G

    价 格：￥电议型 号：T36186产 地：中国大陆

  • T36185Globotriaosylceramides (hydroxy) (porcine)；Globotriaosylceramides (hydroxy) (porcine)Globotriaosylce

    Globotriaosycleramides are glycosphingolipids found in mammalian cell membranes that are synthesized from lactosylceramides . They act as receptors for Shiga and Shiga-like toxins in vitro and in vivo. Globotriaosylceramides accumulate in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease, a lysosomal storage disorder characterized by a deficiency in the enzyme α-galactosidase A. G

    价 格：￥电议型 号：T36185产 地：中国大陆

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