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  • T6026CPI-203CPI-203,CPI203,CPI 203

    CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).

    价 格：￥电议型 号：T6026产 地：美洲

  • T6193Dovitinib Dilactic AcidDovitinib Dilactic Acid,Dovitinib (TKI-258) Dilactic Acid,TKI258 Dilactic aci

    Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of

    价 格：￥电议型 号：T6193产 地：美洲

  • T6289DovitinibDovitinib,TKI258,CHIR-258

    Dovitinib (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit, IC50: 1/2 nM), also effective to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs (IC50: 8-13 nM), less potent to EGFR, InsR, EphA2, c-Met, IGF-1R, Tie2, and HER

    价 格：￥电议型 号：T6289产 地：美洲

  • T8449TC-I2000；化合物TC-I2000TC-I2000

    TC-I2000 is an TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50 of 53 nM.

    价 格：￥电议型 号：T8449产 地：中国大陆

  • T8443LMCI-225 hydrochloride hydrate；化合物 T8443LAA-10021|||AA10021|||MCI225|||DDP-225|||AA-10025|||AA-10026；

    MCI-225 is a norepinephrine reuptake/5-HT3/5-HT reuptake inhibitor. MCI-225 could be effective in the treatment of senile dementia of the Alzheimer type, which is accompanied with both deficit in the BF-cortex cholinergic neuron and cerebral glucose hypometabolism. MCI-225 enhances attentional eye tracking in midpontine pretrigeminal preparation.

    价 格：￥电议型 号：T8443L产 地：中国大陆

  • T83935eIF4A i28；化合物 eIF4A i28eIF4A i28

    eIF4A i28, an inhibitor of the eukaryotic initiation factor-4A (eIF4A) with an IC50 of 8.60 μM in an eIF4A ATPase assay, effectively reduces the viability of BJAB Burkitt lymphoma cells, as indicated by an EC50 of 0.46 μM in a CellTiter-Glo (CTG) luminescence cell viability assay. This compound functions as an RNA-competitive, ATP-uncompetitive eIF4A inhibitor.

    价 格：￥电议型 号：T83935产 地：中国大陆

  • T82329GDI2-IN-1；化合物 GDI2-IN-1GDI2-IN-1

    GDI2-IN-1 (compound (+)-37), a GDP-dissociation inhibitor beta (GDI2) inhibitor, demonstrates potent inhibitory activity with an IC50 of 2.87 μM and a K D of 36 μM, and exhibits excellent in vivo antitumor efficacy in pancreatic xenograft models overexpressing GDI2 [1].

    价 格：￥电议型 号：T82329产 地：中国大陆

  • T81751MPS-Gαi2；化合物 MPS-Gαi2MPS-Gαi2

    MPS-Gαi2, a membrane-permeable sequence (MPS), facilitates research on cell adhesion [1].

    价 格：￥电议型 号：T81751产 地：中国大陆

  • T81678NF(N-Me)GA(N-Me)IL；化合物 NF(N-Me)GA(N-Me)ILAmylin (22-27) [NMeG24, NMeI26], human (IAPP)；Amylin (22-27

    NF(N-Me)GA(N-Me)IL is a biologically active peptide, representing a modified segment (amino acids 22 to 27) of the human islet amyloid polypeptide (hIAPP) sequence NFGAIL. This modification includes N-methylations at G24 and I26, transforming the amyloidogenic and cytotoxic nature of the original sequence into a non-amyloidogenic and non-cytotoxic variant. Moreover, the peptide maintains the ability to bind with high affinity to full-length hIAPP, effectively inhibiting its fibril formation.

    价 格：￥电议型 号：T81678产 地：中国大陆

  • T81379PROTAC GDI2 Degrader-1；化合物 PROTAC GDI2 Degrader-1PROTAC GDI2 Degrader-1

    PROTAC GDI2 Degrader-1 (Compound 21) is a potent degrader of PROTAC GDI2, demonstrating outstanding antitumor activity in vivo within pancreatic xenograft models that overexpress GDI2 [1].

    价 格：￥电议型 号：T81379产 地：中国大陆

  • T78146NaPi2b-IN-2；化合物 NaPi2b-IN-2NaPi2b-IN-2

    NaPi2b-IN-2 (compound 5) serves as a potent inhibitor of the sodium-dependent transport protein 2b (SLC34A2, NaPi2b), exhibiting an IC50 of 38 nM against human NaPi2b. It holds potential for use in hyperphosphatemia research [1].

    价 格：￥电议型 号：T78146产 地：中国大陆

  • T76830Teneliximab；化合物TeneliximabChi220|||Anti-Human CD40 Recombinant Antibody|||BMS 224819；Chi220|||Anti-H

    Teneliximab (Chi220) is a chimeric monoclonal antibody and a tumor necrosis factor receptor superfamily member 5 (CD40) inhibitor that blocks CD40-CD40L interactions.Teneliximab exerts partial agonist activity through CD40 and peripheral B-cell depletion, and may be used to study organ transplant rejection and rheumatoid arthritis.

    价 格：￥电议型 号：T76830产 地：中国大陆

  • T7522GI254023X；化合物GI 254023XGI 254023X；GI 254023X

    GI254023X is a potent MMP9 and ADAM10 inhibitor (IC50s: 2.5 and 5.3 nM) with 100-fold selectivity for the α-secretase ADAM10 over ADAM17 (TACE). GI254023X can remarkably inhibit the proliferation and induce the apoptosis of H929 cells. Its mechanism may be associated with inbihition of Notch1 activation.

    价 格：￥电议型 号：T7522产 地：中国大陆

  • T74984ACBI2；化合物 ACBI2ACBI2

    ACBI2, an orally active and highly potent VHL PROTAC (EC 50: 7 nM), selectively degrades SMARCA2, demonstrating a DC 50 value of 1 nM in RKO cells. This compound holds potential for lung cancer research [1].

    价 格：￥电议型 号：T74984产 地：中国大陆

  • T74186PROTAC-O4I2；化合物PROTAC-O4I2PROTAC-O4I2

    PROTAC-O4I2, a PROTAC ligand targeting splicing factor 3B1 (SF3B1), induced FLAG-SF3B1 degradation in K562 cells with an IC50 value of 0.244 μM. PROTAC-O4I2 induced apoptosis in K562 WT cells.

    价 格：￥电议型 号：T74186产 地：中国大陆

  • T73456DRP1i27；化合物 DRP1i27DRP1i27

    DRP1i27, a potent human dynamin-related protein 1 (Drp1) inhibitor, targets the GTPase site of Drp1, forming hydrogen bonds with Gln34 and Asp218. It mitigates Drp1-mediated mitochondrial fission in cell line models and offers protection against simulated ischemia-reperfusion injury.

    价 格：￥电议型 号：T73456产 地：中国大陆

  • T70605NaPi2b Inhibitor 15；化合物 NaPi2b Inhibitor 15NaPi2b Inhibitor 15

    NaPi2b is primarily expressed in the small intestine, lungs, and testes and plays an important role in phosphate homeostasis. The inhibition of NaPi2b, responsible for intestinal phosphate absorption, is considered to reduce serum phosphate levels, making it a promising therapeutic approach for hyperphosphatemia

    价 格：￥电议型 号：T70605产 地：中国大陆

  • T70191GI261520A；化合物 GI261520AGI261520A

    GI261520A is a potent egfr/erbb2 dual inhibitor

    价 格：￥电议型 号：T70191产 地：中国大陆

  • T69811AGI25696；化合物 AGI25696AGI25696

    AGI-25696 is a MATA2 inhibitor that are useful as therapeutic agents for treating malignancies. AGI-25696 showed in vivo activity in MTAP null tumors. Note: The correct structure of AGI-25696 is CAS#2201065-84-9. Many vendors mistakenly listed CAS#2201066-35-3 as its AGI25696. J. Med. Chem. 2021, 64, 8, 4430–4449 published AGI25696 structure (it is CAS#2201065-84-9).

    价 格：￥电议型 号：T69811产 地：中国大陆

  • T69460TSRI265；化合物 TSRI265TSRI265

    TSRI265 is a novel αvβ3 ligand, disrupting the integrin-MMP2 interaction and showing antiangiogenic activit, inhibiting angiogenesis and tumor growth in vivo.

    价 格：￥电议型 号：T69460产 地：中国大陆

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