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T61283Topoisomerase II inhibitor 3；化合物 Topoisomerase II inhibitor 3Topoisomerase II inhibitor 3
Topoisomerase II inhibitor 3 (Compound 6 h) is an acridone derivative that acts as a Type II DNA topoisomerase (topo II) inhibitor. It specifically inhibits the topo IIα/β subtypes, with an IC50 value of 0.17 μM for topo IIα and 0.23 μM for topo IIβ. This compound elicits significant DNA damage and induces apoptosis by triggering the loss of mitochondrial membrane potential [1].
价 格：￥电议型 号：T61283产 地：中国大陆
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T61054Type II topoisomerase inhibitor 1；化合物 Type II topoisomerase inhibitor 1Type II topoisomerase inhibit
Type II topoisomerase inhibitor 1 is able to be used in the antibacterial area. Type II topoisomerase inhibitor 1 is a potent and selective inhibitor of E. coli DNA gyrase with a IC50 value of 1.7 nM as well as forms hydrogen bonds with Asp73 residue. Type II topoisomerase inhibitor 1 inhibits topoisomerase IV activity with an IC50 value of 0.98 μM [1] [2].
价 格：￥电议型 号：T61054产 地：中国大陆
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T61045Topoisomerase I/II inhibitor 2；化合物 Topoisomerase I/II inhibitor 2Topoisomerase I/II inhibitor 2
Topoisomerase I/II inhibitor 2 (compound 1a) can significantly reduce the xenograft tumor growth in mice model which can be used in treating liver cancer. Topoisomerase I/II inhibitor 2 is a DNA topoisomerase I/II dual inhibitor. Topoisomerase I/II inhibitor 2 is a potent Topoisomerase inhibitor with IC50 values of 6.83 μM and 9.82 μM for LM9 cells and Huh7 cells [1].
价 格：￥电议型 号：T61045产 地：中国大陆
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T61017Topoisomerase II inhibitor 6；化合物 Topoisomerase II inhibitor 6Topoisomerase II inhibitor 6
Topoisomerase II inhibitor 6 (Compound 5) is a tryptanthrin derivative. Topoisomerase II inhibitor 6 is a potent and selective topoisomerase II inhibitor. Topoisomerase II inhibitor 6 blocks the CCRF-CEM cell cycle in the G2 phase and induces DNA double-strand breaks (DSB). Topoisomerase II inhibitor 6 exhibits antiproliferative activity on different tumor cell lines. Topoisomerase II inhibitor 6 has the potential for the research of cancer diseases [1].
价 格：￥电议型 号：T61017产 地：中国大陆
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T60781Topoisomerase II inhibitor 8；化合物 Topoisomerase II inhibitor 8Topoisomerase II inhibitor 8
Topoisomerase II inhibitor 8 (compound 22) shows good anti-proliferative activities and arrest the cell cycle at G2/M phase. Topoisomerase II inhibitor 8 is a potent inhibitor of topoisomerase II (IC 50 = 0.52 μM) [1].
价 格：￥电议型 号：T60781产 地：中国大陆
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T60766Topoisomerase I inhibitor 3；化合物 Topoisomerase I inhibitor 3Topoisomerase I inhibitor 3
Topoisomerase I (Compound ZML-14) inhibitor 3 induces HepG2 cell apoptosis and arrests cell cycle at G2/M phase. Topoisomerase I inhibitor 3 is an inhibitor of topoisomerase I that interact with topoisomerase I-DNA complex [1].
价 格：￥电议型 号：T60766产 地：中国大陆
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T60617Topoisomerase I inhibitor 2；化合物 Topoisomerase I inhibitor 2Topoisomerase I inhibitor 2
Topoisomerase I inhibitor 2 (ZML-8) is a highly selective DNA topoisomerase I (Top1) inhibitor that inhibits Top1 activity and results DNA damage. Topoisomerase I inhibitor 2 blocks G2/M phase and induces apoptosis with anti-tumor effect [1].
价 格：￥电议型 号：T60617产 地：中国大陆
