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  • T77131Clervonafusp alfa；化合物 Clervonafusp alfaClervonafusp alfa

    Clervonafusp alfa (VAL-1221) is a fusion protein designed to target both cytosolic and lysosomal glycogen, thereby addressing the underlying mechanisms of Pompe disease. This compound integrates the Fab segment of a cell-penetrating antibody with recombinant human acid alpha-glucosidase (rhGAA). The antibody´s Fab portion exploits the nucleoside transporter ENT-2 for cytosolic entry, while the rhGAA component accesses lysosomes through mannose-6-phosphate receptors (M6PRs). This dual-targe

    价 格：￥电议型 号：T77131产 地：中国大陆

  • T77112Onfekafusp alfa；化合物 Onfekafusp alfaOnfekafusp alfa

    Onfekafusp alfa (L19TNF) is an engineered homotrimer consisting of L19 antibody peptides in scFv format fused to human TNF, utilized for research in malignant glioma [1] [2].

    价 格：￥电议型 号：T77112产 地：中国大陆

  • T77091Modakafusp alfa；化合物 Modakafusp alfaModakafusp alfa

    Modakafusp alfa (TAK-573) is a humanized anti-CD38 IgG4 monoclonal antibody, with 2 attenuated IFNα2b molecules fused to it. This compound is researched for potential use in treating multiple myeloma [1].

    价 格：￥电议型 号：T77091产 地：中国大陆

  • T77052Latikafusp；化合物 LatikafuspLatikafusp

    Latikafusp (AMG 256), a bifunctional fusion protein, combines a PD-1-targeting antibody with an IL-21 mutein, facilitating IL-21 pathway stimulation in PD-1+ cells. It aims to enhance and sustain the functionality of cytotoxic and memory T cells, thereby inducing anti-tumor immunity. This compound shows promise for research in solid tumors [1] [2].

    价 格：￥电议型 号：T77052产 地：中国大陆

  • T76964Valanafusp alfa；化合物 Valanafusp alfaValanafusp alfa

    Valanafusp alfa (AGT-181) is a recombinant fusion protein that combines a chimeric monoclonal antibody targeting the human insulin receptor (HIR) with human iduronidase (IDUA), facilitating brain penetration. It is utilized in researching Mucopolysaccharidosis type I (MPS I) [1].

    价 格：￥电议型 号：T76964产 地：中国大陆

  • T7685USP25/28 inhibitor AZ1；化合物AZ1AZ1；AZ1

    USP25/28 inhibitor AZ1 (AZ1) (AZ1) is an inhibitor of ubiquitin specific protease (USP) 25/28

    价 格：￥电议型 号：T7685产 地：中国大陆

  • T76843Tebentafusp；化合物 TebentafuspTebentafusp

    Tebentafusp (IMCgp100) is a bispecific fusion protein designed to target the gp100 peptide-HLA-A*02:01 complex, a melanoma-associated antigen. It directs T cells towards melanoma cells expressing gp100 through a high-affinity T-cell receptor (TCR) binding domain coupled with an anti-CD3 domain, promoting T-cell engagement. This action triggers the production of inflammatory cytokines and cytolytic proteins, culminating in the direct lysis of tumor cells [1] [2].

    价 格：￥电议型 号：T76843产 地：中国大陆

  • T75398UDP-sugar pyrophosphorylase (BlUSP)；化合物 UDP-sugar pyrophosphorylase (BlUSP)UDP-sugar pyrophosphoryla

    UDP-sugar pyrophosphorylase (BlUSP) is an enzyme that activates glucose-1-phosphate (Glc-1-P) to UDP-glucose (UDP-Glc) and catalyzes the reversible transfer of the uridyl group from UTP to sugar-1-phosphate, resulting in the production of UDP-sugar and pyrophosphate (PPi) [1].

    价 格：￥电议型 号：T75398产 地：中国大陆

  • T74794USP28-IN-4；USP28 抑制剂4USP28-IN-4

    USP28-IN-4 is a potent USP28 inhibitor with an IC50 value of 0.04 μM against USP28. USP28-IN-4 exhibits anticancer activity and inhibits USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-4 is cytotoxic to human colorectal and lung squamous carcinoma cells and dose-dependently downregulates c-Myc cellular levels through the ubiquitin-proteasome system. -proteasome system to dose-dependently downregulate cellular levels of c-Myc.

    价 格：￥电议型 号：T74794产 地：中国大陆

  • T74793USP28-IN-3；USP28 抑制剂3USP28-IN-3

    USP28-IN-3 is a highly selective USP28 inhibitor with an IC50 value of 0.1 μM against USP28.USP28-IN-3 exhibits anticancer activity and inhibits USP2, USP7, USP8, USP9x, UCHL3, and UCHL5.USP28-IN-3 is cytotoxic to human colorectal and lung squamous carcinoma cells, inhibiting c-cells and c-neutralizing c-neutralizing c-neutralizing c-neutralizing c-neutralizing c-neutralizing c-neutralizing c-cells through the ubiquitin-proteasome system. -proteasome system to dose-dependently downregulate cellu

    价 格：￥电议型 号：T74793产 地：中国大陆

  • T74792USP28-IN-2；化合物 USP28-IN-2USP28-IN-2

    USP28-IN-2 is a selective USP28 inhibitor (IC50 = 0.3 μM), demonstrating high specificity compared to USP2, USP7, USP8, USP9x, UCHL3, and UCHL5. This compound exhibits cytotoxic effects on cancer cells and induces the degradation of c-Myc via the ubiquitin-proteasome pathway. Additionally, USP28-IN-2 reduces ankyrin-1/2 levels in vitro and potentiates the responsiveness of colorectal cancer cells to Regorafenib [1].

    价 格：￥电议型 号：T74792产 地：中国大陆

  • T73257USP7-IN-9；化合物 USP7-IN-9USP7-IN-9

    USP7-IN-9, a potent inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 40.8 nM, effectively induces apoptosis and arrests cell progression at the G0/G1 and S phases in RS4;11 cells. It decreases the protein levels of oncoproteins MDM2 and DNMT1 while enhancing the levels of tumor suppressors p53 and p21.

    价 格：￥电议型 号：T73257产 地：中国大陆

  • T73234USP7-IN-7；化合物 USP7-IN-7USP7-IN-7

    USP7-IN-7, a potent USP7 inhibitor, exhibits an IC50 value of <10 nM. Demonstrating cytotoxicity against both p53-mutant and p53 wild-type blood cancer, as well as neuroblastoma cell lines at low nanomolar concentrations, it holds potential for cancer research applications.

    价 格：￥电议型 号：T73234产 地：中国大陆

  • T73151USP22-IN-1；化合物USP22-IN-1USP22-IN-1

    USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.

    价 格：￥电议型 号：T73151产 地：中国大陆

  • T73136USP7-IN-10；化合物 USP7-IN-10USP7-IN-10

    USP7-IN-10 is a potent inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an inhibition concentration half-maximal (IC50) value of 13.39 nM.

    价 格：￥电议型 号：T73136产 地：中国大陆

  • T72784LOTUB1/USP8-IN-1 HCl；OTUB1/USP8抑制剂1盐酸盐OTUB1/USP8-IN-1 HCl（2858800-98-1 Free base）；OTUB1/USP8-IN-1 HCl

    OTUB1/USP8-IN-1 HCL is a potent dual inhibitor of OTUB1 and USP8 with potential antitumour activity, inhibiting both OTUB1 and USP8. OTUB1/USP8-IN-1 may be used in the study of leukaemia.

    价 格：￥电议型 号：T72784L产 地：中国大陆

  • T72784OTUB1/USP8-IN-1；OTUB1/USP8 抑制剂1OTUB1/USP8-IN-1

    OTUB1/USP8-IN-1 is a potent OTUB1/USP8 inhibitor with potential anticancer activity, with IC50 values of 0.17 and 0.28 nM for OTUB1 and USP8, respectively.OTUB1/USP8-IN-1 can be used in the study of non-small-cell lung cancer.

    价 格：￥电议型 号：T72784产 地：中国大陆

  • T69855USP25/28-IN-AZ2；化合物 USP25/28-IN-AZ2USP25/28-IN-AZ2

    USP25/28-IN-AZ2 is a novel potent, selective, dual usp25/28 inhibitor

    价 格：￥电议型 号：T69855产 地：中国大陆

  • T69820USP7-IN-4；化合物 USP7-IN-4USP7-IN-4

    USP7-IN-4 is a highly potent and selective allosteric USP7 inhibitor.

    价 格：￥电议型 号：T69820产 地：中国大陆

  • T67876USP8-IN-2；化合物USP8-IN-2USP8-IN-2

    USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D. USP8-IN-2 is a potential compound for the treatment of cancer and viral infections.

    价 格：￥电议型 号：T67876产 地：中国大陆

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