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  • T64052PI3K-IN-27；化合物 PI3K-IN-27PI3K-IN-27

    PI3K-IN-27 is a potent inhibitor of PI3K, a large family of lipid signalling kinases that play a key role in cellular processes such as cell growth, differentiation, migration and apoptosis. PI3K-IN-27 has shown research potential in hyperproliferative diseases such as cancer and inflammation or in immune and autoimmune diseases.

    价 格：￥电议型 号：T64052产 地：中国大陆

  • T64040Galectin-3-IN-2；化合物 Galectin-3-IN-2Galectin-3-IN-2

    Galectin-3-IN-2 is a potent inhibitor of polyvalent galactose lectin-3, with an IC50 value of 8.3 μM for Gal-3. Galectin-3 is involved in many metabolic processes associated with cancer.

    价 格：￥电议型 号：T64040产 地：中国大陆

  • T64037CYP3A4-IN-2；化合物 CYP3A4-IN-2CYP3A4-IN-2

    CYP3A4-IN-2 is a specific inhibitor of cytochrome P450 3A4 (CYP3A4) (IC50: 0.055 μM). CYP3A4-IN-2 is a ritonavir analogue with a more hydrophobic R2 side group and stronger inhibition than ritonavir. CYP3A4-IN-2 is capable of acting as an immunosuppressive and antiviral agent.

    价 格：￥电议型 号：T64037产 地：中国大陆

  • T64027ALK-IN-23；化合物 ALK-IN-23ALK-IN-23

    ALK-IN-23 is a potent inhibitor of ALK, acting on ALKWT (IC50: 1.6 nM), ALKL1196M (IC50: 0.71 nM) and ALKG1202R (IC50: 1.3 nM). -IN-23 has inhibitory effects on cancer cell migration and colony formation in vitro. In the H2228 xenograft nude mouse model, ALK-IN-23 showed good anti-tumour effects with low toxicity.

    价 格：￥电议型 号：T64027产 地：中国大陆

  • T64025Top/HDAC-IN-2；化合物 Top/HDAC-IN-2Top/HDAC-IN-2

    Top/HDAC-IN-2 (45b) is a dual inhibitor of Top and HDAC that induces apoptosis and exhibits significant anti-tumour effects.

    价 格：￥电议型 号：T64025产 地：中国大陆

  • T63995BuChE-IN-2；化合物 BuChE-IN-2BuChE-IN-2

    BuChE-IN-2 is an excellent inhibitor of butylcholinesterase (BuChE), acting on BuChE (IC50: 1.28 μM) and NO (IC50: 0.67 μM). BuChE-IN-2 inhibits Aβ aggregation, ROS formation and Cu2+ chelation, exhibits proper blood-brain barrier (BBB) penetration and can be used in Alzheimer´s disease research.

    价 格：￥电议型 号：T63995产 地：中国大陆

  • T63978FAK-IN-2；化合物 FAK-IN-2FAK-IN-2

    FAK-IN-2 is a potent, orally active adherens spot kinase (FAK) inhibitor (IC50: 35 nM) that exhibits antitumour effects. FAK-IN-2 covalently inhibits FAK autophosphorylation in a dose-dependent manner and also inhibits tumour cell formation and migration and induces apoptosis.

    价 格：￥电议型 号：T63978产 地：中国大陆

  • T63972hCA I-IN-2；化合物 hCA I-IN-2hCA I-IN-2

    hCA I-IN-2 (Compound 6d) is a selective inhibitor of human carbonic anhydrase I (hCA I) and acts on hCA I (Ki: 18.8 nM), hCA II (Ki: 375.1 nM), hCAIX (Ki: 1721 nM) and hCAXII (Ki: 283.9 nM).

    价 格：￥电议型 号：T63972产 地：中国大陆

  • T63967Multi-kinase-IN-2；化合物 Multi-kinase-IN-2Multi-kinase-IN-2

    Multi-kinase-IN-2 is an orally active inhibitor of angiokinases. multi-kinase-IN-2 significantly inhibits the activity of angiokinases such as VEGFR-1/2/3, PDGFRα/β, FGFR-1, LYN and c-KIT kinases. -IN-2 significantly attenuates phosphorylation of AKT and ERK proteins, induces apoptosis and has anticancer effects.

    价 格：￥电议型 号：T63967产 地：中国大陆

  • T63957PI3K-IN-29；化合物 PI3K-IN-29PI3K-IN-29

    PI3K-IN-29, a potent inhibitor of PI3K, exhibits substantial inhibition capabilities against U87MG, HeLa, and HL60 cells, with IC50 values of 0.264, 2.04, and 1.14 ?M, respectively. It effectively blocks the PI3K/Akt signaling pathway by preventing the PI3K-catalyzed phosphorylation of Akt [1].

    价 格：￥电议型 号：T63957产 地：中国大陆

  • T63949HIV-1 protease-IN-2；化合物 HIV-1 protease-IN-2HIV-1 protease-IN-2

    HIV-1 protease-IN-2 is a potent inhibitor of HIV-1 protease (IC50: 2.53 nM). HIV-1 protease-IN-2 exhibits antiviral effects against DRV (Darunavir) sensitive or drug resistant HIV-1 mutants.

    价 格：￥电议型 号：T63949产 地：中国大陆

  • T63938AChE-IN-20；化合物 AChE-IN-20AChE-IN-20

    AChE-IN-20 is a potent inhibitor of AChE (IC50: 397.32 nM, Ki: 335.76 nM). AChE-IN-20 inhibits hCA-I (IC50: 84.14 nM, Ki: 97,86 nM), hCA-II (IC50: 69.24 nM, Ki: 76.23 nM) and α GLY (IC50: 52.08 nM, Ki: 57.93 nM).

    价 格：￥电议型 号：T63938产 地：中国大陆

  • T63906hGGPPS-IN-2；化合物 hGGPPS-IN-2hGGPPS-IN-2

    hGGPPS-IN-2 is an analogue of C-2 substituted thienopyrimidinyl bisphosphonates (C2-ThP-BPs) and is a potent inhibitor of human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-2 targets multiple myeloma (MM) cells, induces selective apoptosis, and shows anti-myeloma effects in vivo. It has shown anti-myeloma effects in vivo.

    价 格：￥电议型 号：T63906产 地：中国大陆

  • T63882BRAF V600E/CRAF-IN-2；化合物 BRAF V600E/CRAF-IN-2BRAF V600E/CRAF-IN-2

    BRAF V600E/CRAF-IN-2 is a potent inhibitor of BRAFV600E/CRAF with IC50 values of 0.888 and 0.229 μM, respectively.BRAF V600E/CRAF-IN-2 induces cell cycle arrest at G0/G1 phase and apoptosis in HCT-116 colon cancer cells.BRAF V600E/CRAF-IN-2 has shown research potential for cancer disease. CRAF-IN-2 has shown potential for research into cancer disease.

    价 格：￥电议型 号：T63882产 地：中国大陆

  • T63880DHODH-IN-22；化合物 DHODH-IN-22DHODH-IN-22

    DHODH-IN-22 is a potent, selective, orally active inhibitor of dihydroorotic dehydrogenase (DHODH) (IC50: 0.3 nM) and can be used in acute myeloid leukaemia (AML) studies.

    价 格：￥电议型 号：T63880产 地：中国大陆

  • T63857EGFR-IN-24；化合物 EGFR-IN-24EGFR-IN-24

    EGFR-IN-24 is a potent inhibitor of EGFR and inhibits EGFR (del19/T790M/C797S) and EGFR (L858R/T790M/C797S).

    价 格：￥电议型 号：T63857产 地：中国大陆

  • T63835SphK1-IN-2；化合物 SphK1-IN-2SphK1-IN-2

    SphK1-IN-2 is a potent and selective SphK1 inhibitor that acts on both SphK1 (IC50: 19.81 nM) and SphK2 (IC50>10 nM). sphK1-IN-2 induces cell cycle arrest and apoptosis, exhibits anti-proliferative effects, and can be used to study cancer.

    价 格：￥电议型 号：T63835产 地：中国大陆

  • T63833AAK1-IN-2 TFA；化合物 AAK1-IN-2 TFAAAK1-IN-2 TFA

    AAK1-IN-2 TFA (compound (S)-31) is a selective and potent AAK1 inhibitor (IC50: 5.8 nM) that can cross the blood-brain barrier.

    价 格：￥电议型 号：T63833产 地：中国大陆

  • T63824LRRK2-IN-2；化合物 LRRK2-IN-2LRRK2-IN-2

    LRRK2-IN-2 is a selective, potent, and orally active LRRK2 inhibitor (IC50: 0.6 nM) that crosses the blood-brain barrier. LRRK2-IN-2 can be used to study Parkinson´s disease.

    价 格：￥电议型 号：T63824产 地：中国大陆

  • T63822VEGFR-2-IN-22；化合物 VEGFR-2-IN-22VEGFR-2-IN-22

    VEGFR-2-IN-22 (Compound 25) is an inhibitor of VEGFR-2 and β-tubulin polymerization with an IC50=19.82 nM for VEGFR-2. VEGFR-2-IN-22 is capable of inducing apoptosis.

    价 格：￥电议型 号：T63822产 地：中国大陆

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