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  • T15388GLPG0974GLPG0974

    GLPG0974 is an antagonist of free fatty acid receptor-2 (IC50: 9 nM).

    价 格：￥电议型 号：T15388产 地：美洲

  • T15617JNJ-38877618JNJ-38877618

    JNJ-38877618 is an effective and highly selective inhibitor of Met kinase (IC50s: 2 and 3 nM for wild type and mutant Met, respectively).

    价 格：￥电议型 号：T15617产 地：美洲

  • T16379OglemilastOglemilast,GRC 3886,

    Oglemilast suppresses pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo. Oglemilast is an effective and orally active phosphodiesterase-4 (PDE4) inhibitor (IC50: 0.5 nM for PDE4D3). Oglemilast has the potential for

    价 格：￥电议型 号：T16379产 地：美洲

  • T1800GW 788388GW 788388

    GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.

    价 格：￥电议型 号：T1800产 地：美洲

  • T2113PHA-793887PHA-793887,PHA793887,PHA 793887

    PHA-793887 has been used in trials studying the treatment of Advanced/Metastatic Solid Tumors.

    价 格：￥电议型 号：T2113产 地：美洲

  • T2388Nalfurafine hydrochlorideNalfurafine hydrochloride,TRK-820 hydrochloride,

    Nalfurafine(TRK-820) is an opioid κ-selective agonist; has been approved in Japan for treatment of itch in patients with chronic kidney disease.

    价 格：￥电议型 号：T2388产 地：美洲

  • T6030XL388XL388

    XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.

    价 格：￥电议型 号：T6030产 地：美洲

  • T6095JNJ-38877605JNJ-38877605,JNJ38877605,JNJ 38877605

    JNJ-38877605 is an ATP-competitive c-Met inhibitor (IC50: 4 nM), 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases.

    价 格：￥电议型 号：T6095产 地：美洲

  • T6254IdasanutlinIdasanutlin,RG7388,Ro 5503781

    Idasanutlin (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).

    价 格：￥电议型 号：T6254产 地：美洲

  • T6388AmprenavirAmprenavir,VX-478,141W94

    Amprenavir is a synthetic derivative of hydroxyethylamine sulfonamide that selectively binds to and inhibits human immunodeficiency virus (HIV) protease.

    价 格：￥电议型 号：T6388产 地：美洲

  • T8511TM38837；化合物TM38837TM38837

    TM38837 is an antagonist of cannabinoid receptor type 1 (CB1), with potential for the treatment of obesity and type 2 diabetes.

    价 格：￥电议型 号：T8511产 地：中国大陆

  • T83889C-02；化合物 C-02C-02

    C-02, a proteolysis-targeting chimera (PROTAC) that combines the hexokinase inhibitor lonidamine with the cereblon ligand thalidomide, effectively induces the degradation of hexokinase 2 in 786-O and PANC-1 cells at a concentration of 20 ?M. This compound exhibits cytotoxicity to a range of cancer cells, including 786-O, 4T1, PANC-1, HGC-27, and MCF-7, with IC50 values of 34.07 ?M, 5.08 ?M, 31.53 ?M, 6.11 ?M, and 21.65 ?M, respectively. Additionally, at 20 ?M, C-02 diminishes both the extracellu

    价 格：￥电议型 号：T83889产 地：中国大陆

  • T83888(S)-5-hydroxy-6-methoxy Duloxetine maleate；化合物 (S)-5-hydroxy-6-methoxy Duloxetine maleate(S)-5-hydro

    (S)-5-hydroxy-6-methoxy Duloxetine, an active metabolite of the (S)-duloxetine, functions as a serotonin (5-HT) and norepinephrine reuptake inhibitor. Its formation occurs through the cytochrome P450 (CYP) isoforms CYP1A2 and CYP2D6 via a 5- or 6-hydroxy duloxetine intermediate, followed by a catechol duloxetine intermediate. This compound effectively inhibits the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT) across lipid membranes, with inhibitio

    价 格：￥电议型 号：T83888产 地：中国大陆

  • T83887SLU-10482；化合物 SLU-10482SLU-10482

    SLU-10482, an antiparasitic agent, effectively reduces C. parvum parasitic load in HCT-8 cells with an EC50 value of 0.07 ?M. It exhibits lower affinity for human ether-a-go-go (hERG; Kd = 43 ?M) compared to its counterpart, SLU-2633. When administered in vivo at dosages of 5 and 15 mg/kg twice daily, SLU-10482 significantly decreases fecal oocyst counts in mice infected with C. parvum.

    价 格：￥电议型 号：T83887产 地：中国大陆

  • T83886icFSP1 TFA；化合物 icFSP1 TFAicFSP1 TFA

    icFSP1, an inhibitor of ferroptosis suppressor protein 1 (FSP1), promotes condensation and phase separation of FSP1 in cellular environments at 2.5 ?M concentration but does not affect FSP1´s enzymatic function in cell-free assessments (IC50 = > 30 ?M). This compound selectively induces ferroptosis in HT-1080 fibrosarcoma cells in a dose-dependent manner. Furthermore, in vivo studies show that icFSP1 administered at 50 mg/kg significantly reduces both the volume and weight of tumors in a B

    价 格：￥电议型 号：T83886产 地：中国大陆

  • T83885DXR Inhibitor 11a sodium；化合物 DXR Inhibitor 11a sodium1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase

    DXR inhibitor 11a, with an IC50 value of 0.11 ?M, effectively inhibits P. falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR). It also demonstrates significant activity against P. falciparum´s growth in isolated human erythrocytes, with an IC50 of 0.37 ?M.

    价 格：￥电议型 号：T83885产 地：中国大陆

  • T83884Bio-Ben；化合物 Bio-BenBiotin-Benzoboroxole；Biotin-Benzoboroxole

    Bio-ben functions as a sulfenic acid probe, utilized for labeling both free sulfenic acid and cysteine sulfenic acid within proteins and peptides.

    价 格：￥电议型 号：T83884产 地：中国大陆

  • T83883Biotin Sphingosine；化合物 Biotin SphingosineBiotinyl Sphingosine；Biotinyl Sphingosine

    Biotin sphingosine, a biotinylated derivative of sphingosine (d18:1), serves as a probe in assays for detecting the phosphorylation activity of sphingosine kinase 1 (SPHK1) and SPHK2 in cell lysates.

    价 格：￥电议型 号：T83883产 地：中国大陆

  • T83882XY-4；化合物 XY-4XY-4

    XY-4, a derivative of 1-palmitoyl lysophosphatidic acid (1-palmitoyl LPA094) and an agonist of peroxisome proliferator-activated receptor γ (PPARγ), effectively induces reporter gene expression in RAW 264.7 macrophages harboring a peroxisome proliferator-response element (PPRE) at a concentration of 5 ?M. Unlike its action on PPARγ, XY-4 does not serve as an agonist for lysophosphatidic acid receptor 1 (LPA1), LPA2, or LPA3. Furthermore, at a lower concentration of 1 ?M, it promotes platelet agg

    价 格：￥电议型 号：T83882产 地：中国大陆

  • T838814-(3,4-Difluorobenzo)curcumin；化合物 4-(3,4-Difluorobenzo)curcuminCDF；CDF

    4-(3,4-Difluorobenzo)curcumin (CDF) is a semisynthetic coumarin noted for its antiparasitic and anticancer properties. It effectively reduces the population of Vero cells infected by T. gondii promastigotes and amastigotes, with EC50 values of 0.8 and 0.37 ?M, respectively. Furthermore, at concentrations of 4 and 8 ?M, CDF enhances the efficacy of 5-fluorouracil and oxaliplatin in inhibiting the formation of both primary and secondary colonospheres in chemoresistant HCT116 cells.

    价 格：￥电议型 号：T83881产 地：中国大陆

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