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  • T79275Antiproliferative agent-25；化合物 Antiproliferative agent-25Antiproliferative agent-25

    Antiproliferative Agent-25 (Compound 3s4) is a selective PRMT5 inhibitor displaying an IC50 of 0.11 μM. It elevates hnRNP E1 protein levels and forms hydrogen bond interactions with SAM and the E444 residue of PRMT5. This compound exhibits antiproliferative effects in A549 cells by inducing apoptosis and inhibiting migration, albeit it presents high clearance rates, with half-lives of 21.8 minutes in human liver microsomes and 4.7 minutes in rat liver microsomes [1].

    价 格：￥电议型 号：T79275产 地：中国大陆

  • T79274PRMT5-IN-31；化合物 PRMT5-IN-31PRMT5-IN-31

    PRMT5-IN-31 (Compound 3m), a selective PRMT5 inhibitor (IC50: 0.31 μM), increases hnRNP E1 protein levels by occupying the substrate site of PRMT5 and establishing key interactions with amino acid residues. It exhibits antiproliferative properties against A549 cells through induction of apoptosis and inhibition of cell migration, while demonstrating high metabolic stability in human liver microsomes (T1/2: 132.4 min) [1].

    价 格：￥电议型 号：T79274产 地：中国大陆

  • T79273NMDA receptor antagonist 6；化合物 NMDA receptor antagonist 6NMDA receptor antagonist 6

    NMDA Receptor Antagonist 6 (Compound 13b) functions as an antagonist at the glycine-binding site of the NMDA receptor and demonstrates cytoneuroprotective efficacy. It safeguards PC12 cells from NMDA-induced damage and apoptosis [1].

    价 格：￥电议型 号：T79273产 地：中国大陆

  • T79272BDM91514；化合物 BDM91514BDM91514

    BDM91514 enhances antibiotic efficacy by inhibiting AcrB, effectively curbing the proliferation of E. coli BW25113 with an EC90 of 8 μM when coupled with 8 μg/mL Pyridomycin. Additionally, BDM91514 exhibits favorable plasma and microsomal stability [1].

    价 格：￥电议型 号：T79272产 地：中国大陆

  • T79271FGFR4-IN-14；化合物 FGFR4-IN-14FGFR4-IN-14

    FGFR4-IN-14 (Compound 27i) is a selective FGFR4 inhibitor with an IC50 of 2.4 nM, showing potent inhibition of cell proliferation in the V550L and N535K mutant strains. Specifically, it registers IC50 values of 21 nM against Huh7 cells, 2.5 nM against BaF3/ETV6-FGFR4-V550L cells, and 171 nM against BaF3/ETV6-FGFR4-N535K cells. Demonstrating significant antitumor efficacy in the Huh7 xenograft model, FGFR4-IN-14 is utilized in the research of hepatocellular carcinoma (HCC) [1].

    价 格：￥电议型 号：T79271产 地：中国大陆

  • T79270TMV-IN-6；化合物 TMV-IN-6TMV-IN-6

    TMV-IN-6 (Compound 4g) serves as a novel antiviral and fungicidal agent that impedes tobacco mosaic virus (TMV) assembly, functioning by attachment to TMV coat protein (CP) and disrupting the assembly interaction between TMV CP and RNA [1].

    价 格：￥电议型 号：T79270产 地：中国大陆

  • T7927β-Ionone；β-紫罗兰酮β-lonone；乙位紫罗兰酮|||β-紫罗兰酮|||β-lonone

    β-Ionone (β-lonone) is an end-ring analog of β-carotenoids which widely distributed in fruit and vegetables,with anti-proliferative, anti-metastatic

    价 格：￥电议型 号：T7927产 地：中国大陆

  • T78927PSMA-IN-3；化合物 PSMA-IN-3PSMA-IN-3

    PSMA-IN-3 (compound 17) is a novel, high-affinity inhibitor of Prostate-Specific Membrane Antigen (PSMA) with an inhibitory concentration (IC50) of 13 nM, showing potential for the development of an 18F-labeled radioligand for positron emission tomography (PET) imaging of PSMA in prostate cancer [1].

    价 格：￥电议型 号：T78927产 地：中国大陆

  • T78298Alefacept；化合物 AlefaceptLFA 3TIP|||Human LFA 3IgG fusion protein|||BG 9273；LFA 3TIP|||Human LFA 3IgG

    Alefacept (BG 9273), a fusion protein combining human lymphocyte function-associated antigen 3 with immunoglobulin 1, is utilized in the research of chronic plaque psoriasis [1].

    价 格：￥电议型 号：T78298产 地：中国大陆

  • T77927Pomalidomide-6-OH；化合物 Pomalidomide-6-OHPomalidomide-6-OH

    Pomalidomide-6-OH, a Pomalidomide-derived cereblon (CRBN) ligand, facilitates the recruitment of CRBN protein. This compound can be tethered to a protein ligand through a linker to create a proteolysis-targeting chimeric molecule (PROTAC [1]).

    价 格：￥电议型 号：T77927产 地：中国大陆

  • T76927Bersanlimab；Bersanlimab单抗BI-505；BI-505

    Bersanlimab (BI-505) is a fully human monoclonal antibody targeting Intercellular Adhesion Molecule-1 (ICAM-1).Bersanlimab has anticancer properties and can be used to study relapsed/refractory multiple myeloma.

    价 格：￥电议型 号：T76927产 地：中国大陆

  • T75927α-Conotoxin MII TFA；化合物 α-Conotoxin MII TFAα-Conotoxin MII TFA

    α-Conotoxin MII TFA (α-CTxMII TFA), a peptide consisting of 16 amino acids derived from the venom of Conus magus, selectively inhibits nicotinic acetylcholine receptors (nAChRs) that are composed of α3β2 subunits, demonstrating an inhibitory concentration half-maximal (IC50) value of 0.5 nM. Additionally, it effectively targets β3-containing neuronal nicotinic receptors. [1] [2] [3]

    价 格：￥电议型 号：T75927产 地：中国大陆

  • T72927IMD-catechol；化合物 IMD-catecholIMD-catechol

    IMD-catechol is an innovative dimer compound combining an imidazoquinolinone structure with NF-κB immunomodulatory activity, which enhances treatment outcomes in a CT26 mouse colon carcinoma model and demonstrates low adjuvant-related toxicity.

    价 格：￥电议型 号：T72927产 地：中国大陆

  • T71437M&B 39279；化合物 M&B 39279M&B 39279

    M&B 39279 is a potent inhibitor of plant, yeast and mouse protoporphyrinogen oxidase.

    价 格：￥电议型 号：T71437产 地：中国大陆

  • T71378Exp9270；化合物 Exp9270Exp9270

    Exp9270 is an Angiotensin II receptor antagonist.

    价 格：￥电议型 号：T71378产 地：中国大陆

  • T70927UCD74A HCl；化合物 UCD74A HClUCD74A HCl

    UCD74A HCl is a cell impermeant homolog of UCD38B, inhibitor of uPA (urokinase plasminogen activator).

    价 格：￥电议型 号：T70927产 地：中国大陆

  • T69927Fiduxosin hydrochloride；化合物 Fiduxosin hydrochlorideFiduxosin hydrochloride

    Fiduxosin hydrochloride is an alpha 1a-adrenoceptor antagonist that may be useful in the treatment of Benign Prostatic Hyperplasia.

    价 格：￥电议型 号：T69927产 地：中国大陆

  • T69279Mequitazine sulfoxide；化合物 Mequitazine sulfoxideMequitazine sulfoxide

    Mequitazine sulfoxide is a potent histamine H1 antagonist or antihistamine.

    价 格：￥电议型 号：T69279产 地：中国大陆

  • T69278FPL-55712；化合物 FPL-55712FPL-55712

    FPL-55712 is a CysLT1 leukotriene receptor antagonist.

    价 格：￥电议型 号：T69278产 地：中国大陆

  • T69277(±)-Diclofop；化合物 (±)-Diclofop(±)-Diclofop

    (±)-Diclofop is an Acetyl-CoA carboxylase (ACCase) inhibiting herbicide.

    价 格：￥电议型 号：T69277产 地：中国大陆

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