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  • T64171LXR antagonist 2；化合物 LXR antagonist 2LXR antagonist 2

    LXR antagonist 2 (compound 10rr) is a potent LXR (liver X receptor) inverse agonist, acting on LXRβ (IC50: 0.36 μM) and LXRα (IC50: 2.25 μM). LXR antagonist 2 is an adipogenesis inhibitor that downregulates LXR target genes SREBP-1c, ACC, FAS and SCD-1. LXR antagonist 2 exhibits hypolipidemic activity in Triton WR-1339-induced hyperlipidemic mice.

    价 格：￥电议型 号：T64171产 地：中国大陆

  • T64148LXR agonist 2；化合物 LXR agonist 2LXR agonist 2

    LXR agonist 2 is a potent agonist of the LXR (liver X receptor). LXR agonist 2 stabilises NCOA1 (coactivator), which in turn agonises the LXR.

    价 格：￥电议型 号：T64148产 地：中国大陆

  • T64144FXR antagonist 1；化合物 FXR antagonist 1FXR antagonist 1

    FXR antagonist 1 is a selective, orally active intestinal FXR antagonist with an IC50 value of 2.1 μM. FXR antagonist 1 antagonises intestinal FXR and selectively inhibits intestinal FXR signalling by feedback activation of hepatic FXR. FXR antagonist 1 can improve liver steatosis, inflammation and fibrosis in the NASH (non-alcoholic steatohepatitis) model and can be used to study NASH.

    价 格：￥电议型 号：T64144产 地：中国大陆

  • T63989LXRβ agonist-3；化合物 LXRβ agonist-3LXRβ agonist-3

    LXRβ agonist-3 is a potent and selective LXRβ (liver X receptor β) agonist (EC50: 0.095 μM). LXRβ agonist-3 effectively inhibits U87EGFRvIII cells (IC50: 3.75 μM). .

    价 格：￥电议型 号：T63989产 地：中国大陆

  • T63723LXR agonist 1；化合物 LXR agonist 1LXR agonist 1

    LXR (Liver X receptor) agonist 1 is a potent agonist of LXR, capable of acting on LXR-α (AC50: 1.5 nM) and LXR-β (AC50: 12 nM). LXR agonist 1 has shown research potential in atherosclerosis.

    价 格：￥电议型 号：T63723产 地：中国大陆

  • T63597RXR antagonist 2；化合物 RXR antagonist 2RXR antagonist 2

    RXR antagonist 2 is a potent antagonist of RXR (Ki: 0.391 μM, Kd: 0.281 μM). RXR antagonist 2 has shown research potential for RXR-related diseases.

    价 格：￥电议型 号：T63597产 地：中国大陆

  • T63443XR8-89；化合物 XR8-89XR8-89

    XR8-89, a potent inhibitor of papain-like protease (PLpro), exhibits an IC50 value of 0.1 μM and effectively hinders SARS-CoV-2 replication by inducing conformational changes in the SARS-COV-2 papain-like protease. This compound holds potential for SARS-CoV-2 research applications [1].

    价 格：￥电议型 号：T63443产 地：中国大陆

  • T63415RXR antagonist 1；化合物 RXR antagonist 1RXR antagonist 1

    RXR antagonist 1 is a Retinoid X Receptor (RXR) modulator that exhibits high RXR antagonism (pA2: 8.06). RXR antagonist 1 can be used to study type 2 diabetes.

    价 格：￥电议型 号：T63415产 地：中国大陆

  • T62928XR8-69；化合物 XR8-69XR8-69

    XR8-69 is a SARS-CoV-2 PLpro inhibitor. XR8-69 has a low micromolar antiviral effect in SARS-CoV-2 infected human cells.

    价 格：￥电议型 号：T62928产 地：中国大陆

  • T6287LTariquidar dimesylate；化合物 T6287LD 06008|||XR9576|||D06008|||XR 9576|||Tariquidar dimesilate|||XR-957

    Tariquidar is a P-glycoprotein inhibitor undergoing research as an adjuvant against multidrug resistance in cancer. Tariquidar non-competitively binds to the p-glycoprotein transporter, thereby inhibiting transmembrane transport of anticancer drugs.

    价 格：￥电议型 号：T6287L产 地：中国大陆

  • T6287Tariquidar；他立喹达XR9576；XR9576|||他立喹达

    Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.

    价 格：￥电议型 号：T6287产 地：中国大陆

  • T62021TrxR-IN-2；化合物 TrxR-IN-2TrxR-IN-2

    TrxR-IN-2 is a potential thioredoxin reductase (TrxR) inhibitor. TrxR-IN-2 has research value in the chemotherapy of drug-resistant hepatocellular carcinoma.

    价 格：￥电议型 号：T62021产 地：中国大陆

  • T61647TrxR-IN-5；化合物 TrxR-IN-5TrxR-IN-5

    TrxR-IN-5 (compound 4f) is an efficacious inhibitor of TrxR (thioredoxin reductase) with an IC50 of 0.16 μM. By elevating the levels of reactive oxygen species (ROS), TrxR-IN-5 fosters robust antiproliferative impacts. Additionally, TrxR-IN-5 demonstrates pronounced effects against cancer proliferation and metastasis [1].

    价 格：￥电议型 号：T61647产 地：中国大陆

  • T6053Turofexorate Isopropyl；妥芬异丙酯XL335|||FXR-450|||WAY-362450；XL335|||FXR-450|||WAY-362450|||妥芬异丙酯

    Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM

    价 格：￥电议型 号：T6053产 地：中国大陆

  • T60453TrxR-IN-3；化合物 TrxR-IN-3TrxR-IN-3

    TrxR-IN-3 (Compound 2c) is a effective TrxR inhibitor. TrxR-IN-3 shows strong antiproliferative activities against five human cancer cell lines, especially against breast tumor cells. TrxR-IN-3 increases ROS levels and leads to significant apoptosis by regulating the expression of apoptosis-related proteins in the breast cancer cells. TrxR-IN-3 also triggers the formation of autophagosomes and autolysosomes by promoting the expression of LC3-II and Beclin-1 and reducing the expression of LC3-I a

    价 格：￥电议型 号：T60453产 地：中国大陆

  • T41255Specific PXR antagonist 70；化合物SPA70Specific PXR antagonist 70

    Specific PXR antagonist 70 is a selective pregnane X receptor (PXR) antagonist with an IC50 of 540 nM and Ki of 390 nM for human PCR and enhances the chemosensitivity of cancer cells.

    价 格：￥电议型 号：T41255产 地：中国大陆

  • T41062HXR9；HXR9HXR9

    HXR9 is a cell-permeable peptide that acts as a competitive antagonist of the HOX/PBX interaction. It effectively inhibits the binding between HOX proteins and the transcription factor PBX, specifically in paralogue groups 1 to 8. HXR9 selectively impairs cell proliferation and induces apoptosis in cells with a high expression of the HOXA/PBX3 genes, for instance, MLL-rearranged leukemic cells.

    价 格：￥电议型 号：T41062产 地：中国大陆

  • T40302FXR/TGR5 agonist 1；FXR/TGR5 agonist 1FXR/TGR5 agonist 1

    FXR/TGR5 agonist 1 acts as an agonist on both FXR and TGR5 receptors and is utilized for treating fatty liver disease.

    价 格：￥电议型 号：T40302产 地：中国大陆

  • T35189XRD 489；化合物 T35189XRD489|||XRD-489|||D 489；XRD489|||XRD-489|||D 489

    XRD 489 is a biochemical.

    价 格：￥电议型 号：T35189产 地：中国大陆

  • T35188XR 808；化合物 T35188XR808|||XR-808；XR808|||XR-808

    XR 808 is a biochemical.

    价 格：￥电议型 号：T35188产 地：中国大陆

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