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T79758BQZ-485；化合物 BQZ-485BQZ-485
BQZ-485, a potent GDI2 inhibitor, interacts with Tyr245 to disrupt the native GDI2-Rab1A interaction. This disruption impedes vesicular transport from the endoplasmic reticulum (ER) to the Golgi apparatus, triggering subsequent paraptosis events [1].
价 格：￥电议型 号：T79758产 地：中国大陆
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T79677SARS-CoV-2-IN-58；化合物 SARS-CoV-2-IN-58SARS-CoV-2-IN-58
SARS-CoV-2-IN-58 (Compound 21H) serves as an antiviral agent targeting SARS-CoV-2, demonstrating efficacy with an EC50 of 18 μM. It specifically inhibits the SARS-CoV-2 main protease (Mpro) with an IC50 value of 0.35 μM [1].
价 格：￥电议型 号：T79677产 地：中国大陆
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T79658PI3Kδ-IN-14；化合物 PI3Kδ-IN-14PI3Kδ-IN-14
PI3Kδ-IN-14 (Compound (S)-29), a selective PI3Kδ inhibitor with an IC50 of 0.8 nM and a Kd of 84.8 nM, targets the ATP-binding site within the kinase domain of PI3Kδ. This compound exhibits anti-inflammatory properties by impeding the PI3K/AKT pathway and is noted for alleviating acute lung injury (ALI) [1].
价 格：￥电议型 号：T79658产 地：中国大陆
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T79589Antifungal agent 71；化合物 Antifungal agent 71Antifungal agent 71
Antifungal agent 71 (compound 6r), a trifluoromethyl pyrimidine derivative, displays potent in vitro activity against F. oxysporum, evidenced by an EC 50 value of 3.61 μg/mL [1].
价 格：￥电议型 号：T79589产 地：中国大陆
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T79588hCA/VEGFR-2-IN-3；化合物 hCA/VEGFR-2-IN-3hCA/VEGFR-2-IN-3
hCA/VEGFR-2-IN-3 (compound 8j) is an indolinonylbenzenesulfonamide with potential as a dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2. This compound inhibits VEGFR-2 with an IC50 of 358 nM and exhibits high affinity for hCAs, evidenced by Ki values of 4.2 nM for hCA IX, 22.9 nM for hCA II, 25.1 nM for hCA I, and 28.0 nM for hCA XII. Additionally, hCA/VEGFR-2-IN-3 demonstrates antiproliferative activity specifically against breast cancer cells that overexpress VEGFR-2 [1].
价 格：￥电议型 号：T79588产 地：中国大陆
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T79587hCA/VEGFR-2-IN-2；化合物 hCA/VEGFR-2-IN-2hCA/VEGFR-2-IN-2
Compound 8g (hCA/VEGFR-2-IN-2) is an indolinonylbenzenesulfonamide identified as a potential dual inhibitor targeting cancer-associated isozymes hCA IX/XII and the angiogenic receptor VEGFR-2. It demonstrates VEGFR-2 inhibition with an IC50 of 204 nM and high affinity for hCAs, exhibiting Kis of 3.6 nM for hCA IX, 16.1 nM for hCA II, 16.7 nM for hCA XII, and 75.3 nM for hCA I. Furthermore, compound 8g exhibits antiproliferative effects on breast cancer cells overexpressing VEGFR-2 [1].
价 格：￥电议型 号：T79587产 地：中国大陆
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T795863′-Acetate-ATP；化合物 3′-Acetate-ATP3′-Acetate-ATP
3’-Acetate-ATP, an analogue of ATP and its acetylation product, exhibits maximum ultraviolet absorption at 259 nm in neutral aqueous solutions. It impedes nucleic acid polymerization [1].
价 格：￥电议型 号：T79586产 地：中国大陆
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T79585Anti-inflammatory agent 50；化合物 Anti-inflammatory agent 50Anti-inflammatory agent 50
Anti-inflammatory agent 50 (compound a1), a derivative of Fusidic acid, exerts its effects through inhibition of inflammatory mediators including NO, IL-6, and TNF-α. It mitigates acute lung injury by modulating these mediators and suppressing the MAPK, NF-κB, and NLRP3 inflammasome signaling pathways [1].
价 格：￥电议型 号：T79585产 地：中国大陆
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T79584AChE-IN-37；化合物 AChE-IN-37AChE-IN-37
AChE-IN-37 (compound A2) is an acetylcholinesterase inhibitor with an inhibitory concentration (IC50) of 0.23 ?M. It alters reactive oxygen species (ROS) levels and modulates the gene expression of nuclear factor erythroid 2-related factor 2 (NRF2) [1].
价 格：￥电议型 号：T79584产 地：中国大陆
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T79583AChE-IN-36；化合物 AChE-IN-36AChE-IN-36
AChE-IN-36 (compound A4) is an acetylcholinesterase inhibitor with an IC50 of 0.04 μM, influencing ROS levels and modulating the gene expression of NRF2 [1].
价 格：￥电议型 号：T79583产 地：中国大陆
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T79582Antitumor agent-116；化合物 Antitumor agent-116Antitumor agent-116
Antitumor Agent-116 (Compound 6C) is an anti-tumor agent that exhibits anti-proliferative properties and induces apoptosis. It demonstrates binding affinity for the MELK receptor [1].
价 格：￥电议型 号：T79582产 地：中国大陆
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T79581JAK2-IN-9；化合物 JAK2-IN-9JAK2-IN-9
Compound A8, known as JAK2-IN-9, is a selective JAK2 inhibitor with an IC50 of 5 nM. It effectively inhibits the phosphorylation of JAK2, STAT3, and STAT5, possesses metabolic stabilities, and induces apoptosis. This compound is utilized in the study of myeloproliferative neoplasms (MPNs) [1].
价 格：￥电议型 号：T79581产 地：中国大陆
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T79580Antitumor agent-115；化合物 Antitumor agent-115Antitumor agent-115
Antitumor agent-115 (SS-12) is a potent anti-tumor compound, exhibiting an IC50 range of 0.34 μM-24.14 μM against the 4T1 mouse breast cancer cell line. It impedes the cell cycle, diminishes mitochondrial membrane potential, and triggers apoptosis in these cells, with an IC50 for cell viability spanning 8-25 μmol/L. This compound is applicable in breast cancer research [1].
价 格：￥电议型 号：T79580产 地：中国大陆
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T7958Methyl arachidate；花生酸甲酯Methyl Icosanoate；花生酸甲酯|||Methyl Icosanoate
Methyl arachidate (Methyl Icosanoate) is an esterified form of arachidic acid
价 格：￥电议型 号：T7958产 地：中国大陆
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T79558fac-[Re(CO)3(L3)(H2O)][NO3]；化合物 fac-[Re(CO)3(L3)(H2O)][NO3]fac-[Re(CO)3(L3)(H2O)][NO3]
Fac-[Re(CO)3(L3)(H2O)][NO3] (Compound 3), a rhenium(I) tricarbonyl aqua complex, acts as an anticancer agent through the induction of mitochondrial dysfunction. It exhibits cytotoxicity against prostate cancer cells, demonstrating an IC50 value of 0.32 μM in PC-3 cells. This compound predominantly localizes to the mitochondria, reducing ATP production and triggering paraptosis in PC3 cells, while not initiating necrosis, apoptosis, or autophagy [1].
价 格：￥电议型 号：T79558产 地：中国大陆
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T79519YXG-158；化合物 YXG-158YXG-158
YXG-158 (Compound 23-h), an orally active androgen receptor (AR) degrader and cytochrome P450 17A1 (CYP17A1) inhibitor, exhibits AR degradation with a DC50 of 1.28 μM and CYP17A1 inhibition with an IC50 of 100 nM. It is under investigation for potential use in research on enzalutamide-resistant prostate cancer [1].
价 格：￥电议型 号：T79519产 地：中国大陆
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T79458YF704；化合物 YF704YF704
YF704 (compound 4w), a selective allosteric inhibitor of SHP2, exhibits antiproliferative effects and induces apoptosis in cancer cells with an IC50 of 0.25 μM. Furthermore, it downregulates Erk1/2 and Akt phosphorylation levels in cancer cells [1].
价 格：￥电议型 号：T79458产 地：中国大陆
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T79358PF-07247685；化合物 PF-07247685PF-07247685
PF-07247685, a potent BCKDC kinase (BDK) inhibitor (EC 50 = 2.2 nM), enhances the binding between BDK and the BCKDH E2 core subunit to block E1 phosphorylation. BDK regulation is crucial for BCKDH activity, which manages the rate-limiting step in the catabolism of branched-chain amino acids (BCAA). Dysfunctional BCAA metabolism is linked to various cardiometabolic disorders such as heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity. PF-072
价 格：￥电议型 号：T79358产 地：中国大陆
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T79258sEH inhibitor-16；化合物 sEH inhibitor-16sEH inhibitor-16
sEH Inhibitor-16, a potent soluble epoxide hydrolase (sEH) inhibitor, exhibits an IC50 of 2 nM. It diminishes inflammatory damage associated with cerulein-induced acute pancreatitis (AP) in mice, making it suitable for inflammation and immunology research [1].
价 格：￥电议型 号：T79258产 地：中国大陆
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T79158h15-LOX-2 inhibitor 1；化合物 h15-LOX-2 inhibitor 1h15-LOX-2 inhibitor 1
Compound 105 (h15-LOX-2 inhibitor 1) is a potent inhibitor of human epithelial 15-lipoxygenase-2 (h15-LOX-2), exhibiting an IC50 of 0.34 μM [1].
价 格：￥电议型 号：T79158产 地：中国大陆
