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T37644Bengamide B;Bengamide BBengamide B
Potent inhibitor of NF-κB activation (IC50 = 85 nM); decreases IκBα phosphorylation. Attenuates LPS-induced nitric oxide production and expression of TNF-α, IL-6 and MCP. Suppresses proliferation of HeLa and HCT116 cells. Anti-inflammatory and antitumor.
价 格:¥电议型 号:T37644产 地:中国大陆
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T37582Ganglioside GM1 Mixture (ovine) (ammonium salt);Ganglioside GM1 Mixture (ovine) (ammonium salt)Gangl
Ganglioside GM1is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue.1,2It is found in a large variety of cells, including immune cells and neurons, and is enriched in lipid rafts in the cell membrane.3It associates with growth factor receptors, including TrkA, TrkB, and the GDNF receptor complex containing Ret and GFRα, and is required for TrkA expression on the cell surface. Ganglioside GM1interacts with other proteins to increase calcium i
价 格:¥电议型 号:T37582产 地:中国大陆
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T37562C16 Ceramide;N-棕榈酰神经鞘氨醇N-acylsphingosine|||C16 Ceramide (d18:1/16:0)|||Palmitoyl Ceramide|||N-Palmit
C16 Ceramide (Palmitoyl Ceramide) is a naturally occurring small molecule that activates p53 by directly and selectively binding to it.
价 格:¥电议型 号:T37562产 地:中国大陆
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T37542Anguinomycin A;Anguinomycin AAnguinomycin A
Anguinomycin A is an antibiotic first isolated from a Streptomyces sp. and analog of leptomycin B that is highly cytotoxic to mouse P388 leukemia cells in vitro (IC50 = 0.1-0.2 ng/ml). It also demonstrates antitumor activity at 62.5 μg/kg/day against Lewis lung carcinoma in mice.
价 格:¥电议型 号:T37542产 地:中国大陆
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T37496Alamandine;Angiotensin A (1-7)Alamandine
Alamandine can be formed from angiotensin A by action of ACE-2 or directly from angiotensin-(1-7) by decarboxylation of its aspartate residue. The angiotensin A analog produces effects resembling those of Ang II (1-7). However, it acts independently of the two known vasodilators receptors of the RAS (Mas and angiotensin II type 2). To produce its effects, alamandine binds to the Mas-related receptor, MrgD. A novel orally active formulation of alamandine produced a long-term antihypertensive effe
价 格:¥电议型 号:T37496产 地:中国大陆
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T37495Angiotensin (1-7) (acetate);化合物 Angiotensin (1-7) (acetate)Angiotensin (1-7) (acetate)
Angiotensin 1-7 (Ang-(1-7)) acetate, an endogenous heptapeptide from the renin-angiotensin system (RAS), exhibits cardioprotective effects through its anti-inflammatory and anti-fibrotic activities in cardiac cells. It effectively inhibits purified canine ACE activity (IC 50 =0.65 μM) and serves as a local synergistic modulator of kinin-induced vasodilation by hindering ACE and facilitating nitric oxide release. Additionally, this compound prevents Ang II-induced proliferation and hypertrophy in
价 格:¥电议型 号:T37495产 地:中国大陆
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T37473SBFI AM;SBFI AMSodium-binding Benzofuran Isophthalate Acetoxymethyl ester;Sodium-binding Benzofuran
SBFI AM is a membrane-permeant, fluorescent Na+ indicator dye. It is selective for Na+ over K+ with Kd values of 20 and 120 mM for these ions, respectively. [1]Increasing concentration of Na+ increases the ratio of excitation efficiency at 330-345 nm to that at 370-390 nm with emission collected at 450-550 nm. [1] Therefore, ratio fluorometry and imaging can be performed with the same wavelengths. SBF AM is suitable for single intracellular dye injection and is typically used for high-resolutio
价 格:¥电议型 号:T37473产 地:中国大陆
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T3747syringaldehyde;丁香醛Syringic aldehyde|||Springaldehyde;Syringic aldehyde|||丁香醛|||Springaldehyde
syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis. Syringaldehyde moderately inhibits COX-2 activity with an IC50 of 3.5 μg/mL. Anti-hyperglycemic and anti-inflammatory activities.
价 格:¥电议型 号:T3747产 地:中国大陆
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T37436C12-Ceramide;化合物 C12-CeramideN-Laurylsphingosine|||C12 Ceramide (d18:1/12:0)|||N-Lauroyl-D-erythro-s
C12-Ceramide (C12 Ceramide (d18:1/12:0)), a ceramide present in the protective membranes surrounding umbilical cord blood vessels in infants born to women with pre-eclampsia, can be used to assess the level of ASM activity in the plasma of patients with Niemann-Pick disease.
价 格:¥电议型 号:T37436产 地:中国大陆
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T37427(2R/S)-6-PNG;化合物 (2R/S)-6-PNG6-Prenylnaringenin|||(±)-6-Prenylnaringenin;6-Prenylnaringenin|||(±)-6-
(2R/S)-6-PNG (6-Prenylnaringenin) is a novel natural histone deacetylase inhibitor with anticancer and antitumor activity, and blocks T-type calcium channels to reduce neuropathic and visceral pain in mice.
价 格:¥电议型 号:T37427产 地:中国大陆
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T37404O-Desmethylangolensin;O-DesmethylangolensinO-Desmethylangolensin
O-Desmethylangolensin is a gut microbiota metabolite of daidzein, a soy isoflavone. It demonstrates antioxidant activity[1][2].
价 格:¥电议型 号:T37404产 地:中国大陆
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T37343’,4’-Dihydroxyacetophenone;二羟基苯乙酮Qingxintong|||4-Acetylpyrocatechol;二羟基苯乙酮|||Qingxintong|||4-Acetyl
3´,4´-Dihydroxyacetophenone (Qingxintong) is an active constituent of Chinese medicine. It is platelet aggregation Inhibitor and also has anti-arrhythmia activity.
价 格:¥电议型 号:T3734产 地:中国大陆
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T37295Ganglioside GM1 Asialo Mixture;Ganglioside GM1 Asialo MixtureGanglioside GM1 Asialo Mixture
Ganglioside GM1 asialo is a component of cellular lipid rafts and can be formed by the cleavage of the sialic acid residue from ganglioside GM1 by neuraminidase. Ganglioside GM1 asialo is a glycolipid receptor for P. aeruginosa flagellin and stimulates defensive responses in host cells, including extracellular ATP release, calcium mobilization, and ERK1/2 phosphorylation when stimulated by flagellin and an anti-ganglioside GM1 asialo antibody. The percentage of ganglioside GM1 asialo-positive na
价 格:¥电议型 号:T37295产 地:中国大陆
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T3727Methyl syringate;丁香酸甲酯Syringic Acid Methyl Ester;Syringic Acid Methyl Ester|||丁香酸甲酯
Methyl syringate (Syringic Acid Methyl Ester) has a unique inhibitory activity toward aflatoxin production with a different mode of action from that of gallic acid. Methyl syringate from K. pictus is a specific and selective activator of hTRPA1, can regulate food intake and gastric emptying through a TRPA1-mediated pathway and, by extension, can contribute to weight suppression.
价 格:¥电议型 号:T3727产 地:中国大陆
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T37187D-erythro/L-threo Lysosphingomyelin (d18:1);D-erythro/L-threo Lysosphingomyelin (d18:1)D-erythro/L-t
Lysosphingomyelin is an endogenous bioactive sphingolipid and a constituent of lipoproteins.1,2It is produced by the removal of the acyl group from sphingomyelin by a deacylase and acts as a precursor in the biosynthesis of sphingosine-1-phosphate . D-erythroLysosphingomyelin is an agonist of the S1P receptors S1P1, S1P2, and S1P3(EC50s = 167.7, 368.1, and 482.6 nM, respectively, for the human receptors).3It is also an agonist of the orphan receptor ovarian cancer G protein-coupled receptor 1 (O
价 格:¥电议型 号:T37187产 地:中国大陆
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T37111Corticotropin-releasing factor (human) (acetate);Corticotropin-releasing factor (human) (acetate)Cor
Human CRF acetate is a chemical compound that effectively stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary.
价 格:¥电议型 号:T37111产 地:中国大陆
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T37010D-threo Sphinganine (d18:0);D-threo Sphinganine (d18:0)D-threo Sphinganine (d18:0);D-threo Sphingani
D-threo Sphinganine (d18:0) is a synthetic bioactive sphingolipid and stereoisomer of sphinganine (d18:0) and L-erythro sphinganine (d18:0) . It induces autophagy in HCT116 cells when used at a concentration of 12 μM. D-threo Sphinganine (d18:0) is metabolized via sphinganine N-acyltransferase and sphinganine kinase in vivo in rat liver.
价 格:¥电议型 号:T37010产 地:中国大陆
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T36987N,N-dimethyl Sphinganine (d18:0);N,N-dimethyl Sphinganine (d18:0)N,N-dimethyl Sphinganine (d18:0);N,
N,N-dimethyl Sphinganine (d18:0) is a sphingolipid that increases during development ofL. donovanipromastigotes.1
价 格:¥电议型 号:T36987产 地:中国大陆
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T36906Nanangenine G;Nanangenine GNanangenine G
Nanangenine G is a drimane sesquiterpene that has been found inAspergillus.1It is cytotoxic to NS-1 mouse myeloma cells (IC50= 47 μg/ml).
价 格:¥电议型 号:T36906产 地:中国大陆
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T36905Nanangenine F;Nanangenine FNanangenine F
Nanangenine F is a drimane sesquiterpene fungal metabolite that has been found inA. nanangensis.1It is active againstB. subtilis(IC50= 78 μg/ml) and cytotoxic to NS-1, DU145, and MCF-7 cancer and NFF non-cancerous cells (IC50s = 49, 95, 49, and 84 μg/ml, respectively).
价 格:¥电议型 号:T36905产 地:中国大陆