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T17928Lenalidomide-C5-NH2；化合物 T17928E3 ligase Ligand-Linker Conjugates 31|||Cereblon Ligand-Linker Conjuga
Lenalidomide-C5-NH2 is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs[1].
价 格：￥电议型 号：T17928产 地：中国大陆
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T17908VHL Ligand-Linker Conjugates 15；化合物 T17908E3 Ligase Ligand-Linker Conjugates 56；E3 Ligase Ligand-Lin
VHL Ligand-Linker Conjugates 15 is a chemical compound that combines a VHL ligand, which targets the E3 ubiquitin ligase, with a PROTAC linker. It is specifically designed for the creation of PROTACs[1].
价 格：￥电议型 号：T17908产 地：中国大陆
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T17898cIAP1 Ligand-Linker Conjugates 7；化合物 T17898E3 ligase Ligand-Linker Conjugates 44；E3 ligase Ligand-Li
cIAP1 Ligand-Linker Conjugates 7 is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a PROTAC linker. It is utilized in the design of SNIPERs[1].
价 格：￥电议型 号：T17898产 地：中国大陆
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T17888cIAP1 Ligand-Linker Conjugates 6 hydrochloride；化合物 T17888E3 ligase Ligand-Linker Conjugates 35 hydro
cIAP1 Ligand-Linker Conjugates 6 hydrochloride is a compound that combines an IAP ligand for the E3 ubiquitin ligase and a PROTAC linker. It is utilized for the purpose of designing SNIPERs[1].
价 格：￥电议型 号：T17888产 地：中国大陆
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T1788Tazemetostat；化合物EPZ6438E-7438|||EPZ6438；E-7438|||EPZ6438
Tazemetostat (EPZ6438) is a histone methyltransferase EZH2 inhibitor (IC50=11 nM) that is orally active, selective, and SAM-competitive. Tazemetostat exhibits antitumor activity and may be used for the treatment of epithelioid sarcoma/follicular lymphoma.
价 格：￥电议型 号：T1788产 地：中国大陆
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T17879E3 ligase Ligand 8；化合物E3 ligase Ligand 8E3 ligase Ligand 8
E3 ligase Ligand 8 is a ligand for E3 ubiquitin ligase. The E3 ligase Ligand 8 can be linked to protein ligands through linkers to form PROTACs, which are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
价 格：￥电议型 号：T17879产 地：中国大陆
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T17868E3 ligase Ligand 10；化合物 T17868E3 ligase Ligand 10
E3 ligase Ligand 10 serves as a ligand for E3 ubiquitin ligase and can be conjugated to a protein ligand through a linker, resulting in the formation of PROTACs. These PROTACs act as inducers of ubiquitination-mediated degradation, specifically targeting cancer-promoting proteins[1].
价 格：￥电议型 号：T17868产 地：中国大陆
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T17818Thalidomide-O-amido-C4-NH2；化合物 T17818E3 Ligase Ligand-Linker Conjugates 19|||Cereblon Ligand-Linker
Thalidomide-O-amido-C4-NH2 (Cereblon Ligand-Linker Conjugates 6) is a synthesized ligand-linker conjugate that combines a Thalidomide-based cereblon ligand with a linker. It functions as an E3 ligase ligand-linker conjugate and finds applications in the synthesis of PROTACs[1].
价 格：￥电议型 号：T17818产 地：中国大陆
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T15228endo-BCN-PEG4-NHS ester；化合物 T15228endo-BCN-PEG4-NHS ester
endo-BCN-PEG4-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格：￥电议型 号：T15228产 地：中国大陆
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T15218EN460；化合物 T15218EN460
EN460 is an inhibitor of endoplasmic reticulum oxidation 1 (ERO1) and interacts selectively (IC50: 1.9 uM) with the reduced, active form of ERO1α and prevents its reoxidation.
价 格：￥电议型 号：T15218产 地：中国大陆
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T15188E-?6123；化合物 T15188E-?6123
E-6123 is an antagonist of platelet-activating factor (PAF) receptor.
价 格：￥电议型 号：T15188产 地：中国大陆
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T11234ESI-08；化合物ESI-08ESI-08
ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation.
价 格：￥电议型 号：T11234产 地：中国大陆
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T11228ERK2 IN-1；化合物 T11228ERK2 IN-1
ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM.
价 格：￥电议型 号：T11228产 地：中国大陆
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T11178ELN318463；化合物 T11178ELN 318463；ELN 318463
ELN 318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN 318463 is 51-fold more selective for PS1.ELN 318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor.
价 格：￥电议型 号：T11178产 地：中国大陆
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T11162EGFR-IN-8；化合物EGFR-IN-8EGFR-IN-8
EGFR-IN-8, a dual inhibitor targeting both EGFR and c-Met, shows potential as a promising candidate for further development in treating EGFR TKI-resistant NSCLC.
价 格：￥电议型 号：T11162产 地：中国大陆
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T10758Centanafadine；化合物 T10758EB-1020；EB-1020
Centanafadine is a dual inhibitor of norepinephrine (NE)/dopamine (DA) transporter, also inhibits serotonin transporter (IC50s: 6 nM, 38 nM, and 83 nM for human NE, DA, and serotonin transporter).
价 格：￥电议型 号：T10758产 地：中国大陆
