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T73960Febuxostat isopropyl isomer;化合物 Febuxostat isopropyl isomerFebuxostat isopropyl isomer
Febuxostat isopropyl isomer is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K i of 0.6 nM [1] .
价 格:¥电议型 号:T73960产 地:中国大陆
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T72269TAK-960 dihydrochloride;化合物 TAK-960 dihydrochlorideTAK-960 dihydrochloride
TAK-960 dihydrochloride is an orally administered, selective polo-like kinase 1 (PLK1) inhibitor, exhibiting a potent IC 50 of 0.8 nM. It also targets PLK2 and PLK3 with IC 50 values of 16.9 and 50.2 nM, respectively. This compound effectively inhibits the proliferation of a broad range of cancer cell lines and demonstrates substantial efficacy against various tumor xenografts.
价 格:¥电议型 号:T72269产 地:中国大陆
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T7200TAK-960;化合物TAK-960TAK-960
TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively.
价 格:¥电议型 号:T7200产 地:中国大陆
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T71960Aminogenistein;化合物 AminogenisteinAminogenistein
Aminogenistein inhibits protein-tyrosine kinase activity of p56lck.
价 格:¥电议型 号:T71960产 地:中国大陆
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T71754AV-9606-129;化合物 AV-9606-129AV-9606-129
AV-9606-129" is a USP28 inhibitor"
价 格:¥电议型 号:T71754产 地:中国大陆
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T70960Maprotiline-d3 hydrochloride;化合物 Maprotiline-d3 hydrochlorideMaprotiline-d3 hydrochloride
Maprotiline-d3 is intended for use as an internal standard for the quantification of maprotiline by GC- or LC-MS. Maprotiline is a tricyclic antidepressant. It binds to the norepinephrine transporter (NET) and is selective for NET over the serotonin and dopamine transporters. Maprotiline also binds to the serotonin (5-HT) receptor subtype 5-HT2A, as well as histamine H1, muscarinic acetylcholine, α1-adrenergic, and dopamine D2 receptors. In vivo, maprotiline inhibits norepinephrine reuptake in r
价 格:¥电议型 号:T70960产 地:中国大陆
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T70688S 0960;化合物 S 0960S 0960
S 0960 is a dimeric bile acid analogue that acts as a specific inhibitor of the apical sodium-dependent bile salt transporter (ASBT) in the ileum.
价 格:¥电议型 号:T70688产 地:中国大陆
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T69960CJ-15161 hydrochloride;化合物 CJ-15161 hydrochlorideCJ-15161 hydrochloride
CJ-15161 hydrochloride is the salt form of CJ-15161 (free base), an opioid κ-receptor agonist, is undergoing development with Pfizer as an analgesic agent.
价 格:¥电议型 号:T69960产 地:中国大陆
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T6960LPU-H71 HCl;PU-H71盐酸盐PU-H71 HCl(873436-91-0 Free base)|||Zelavespib HCl;PU-H71 HCl(873436-91-0 Free b
PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT. PU-H71 HCL shows antitumor activity in many preclinical models of malignancy. PU-H71 HCL has an inhibitory effect on the protein expression levels of Rad51 and Ku70, which may be associated with the double chain break repair in the homologous recombination pathway and non-homologous end-joining pathway.
价 格:¥电议型 号:T6960L产 地:中国大陆
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T69609TG11-77 free base;化合物 TG11-77 free baseTG11-77 free base
TG11-77 free base is a novel, Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist. TG11-77 free base has a Schild KB of 9.7 nM on EP2, a water solubility of 2.5 mM, a brain-to-plasma ratio of 0.4, and a plasma half-life of 2.4 h in mice. TG11-77 free base are representative second generation EP2 antagonists with improved pharmacodynamic and pharmacokinetic properties.
价 格:¥电议型 号:T69609产 地:中国大陆
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T69608TG11-77 HCl;化合物 TG11-77 HClTG11-77 HCl
TG11-77 HCl is a novel, Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist. TG11-77 HCl has a Schild KB of 9.7 nM on EP2, a water solubility of 2.5 mM, a brain-to-plasma ratio of 0.4, and a plasma half-life of 2.4 h in mice. TG11-77 HCl are representative second generation EP2 antagonists with improved pharmacodynamic and pharmacokinetic properties.
价 格:¥电议型 号:T69608产 地:中国大陆
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T69607Dersimelagon phosphate;化合物 Dersimelagon phosphateDersimelagon phosphate
Dersimelagon phosphate is a selective melanocortin-1 receptor (MC1R) agonist that increases skin melanin without sun exposure and is being developed to increase light tolerance in EPP/XLP patients.
价 格:¥电议型 号:T69607产 地:中国大陆
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T69606ARN23746;化合物 ARN23746ARN23746
ARN23746 is a NKCC1 Inhibitor for the Treatment of Core Symptoms in Down Syndrome.
价 格:¥电议型 号:T69606产 地:中国大陆
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T69604Cleistanthin;化合物 CleistanthinCleistanthin
Cleistanthin is a member of the class of cleistanthins that is the 4-O-3,4-di-O-methyl-beta-D-xylopyranoside of 1,3-dihydronaphtho[2,3-c]furan-4-ol which is substituted by an oxo group at position 1, methoxy groups at positions 6 and 7, and a 1,3-benzodioxol-5-yl group at position 9. It is one of the toxic principles in Cleistanthus collinus. It has a role as an antihypertensive agent, an alpha-adrenergic antagonist and a diuretic. It is a xylose derivative and a member of cleistanthins.
价 格:¥电议型 号:T69604产 地:中国大陆
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T69603BR103354;化合物 BR103354BR103354
BR103354 is a novel fibroblast activation protein (FAP) inhibitor with anti-diabetic and anti-steatotic effects. BR103354 inhibited FAP with an IC50 value of 14 nM, showing high selectivity against dipeptidyl peptidase (DPP)-related enzymes and prolyl oligopeptidase (PREP). BR103354 exhibited good pharmacokinetic properties as evidenced by oral bioavailability of 48.4% and minimal hERG inhibition. Single co-administration of BR103354 with hFGF21 reduced nonfasting blood glucose concentrations, i
价 格:¥电议型 号:T69603产 地:中国大陆
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T69602ONO-DI-004;化合物 ONO-DI-004ONO-DI-004
ONO-DI-004 is a selective EP1 Prostanoid receptor agonist.
价 格:¥电议型 号:T69602产 地:中国大陆
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T69601ER272;化合物 ER272ER272
ER272 is a natural PKC activator, inducing hippocampal neurogenesis.
价 格:¥电议型 号:T69601产 地:中国大陆
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T69600Spermidine-d6;化合物 Spermidine-d6Spermidine-d6
Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine by GC- or LC-MS. Spermidine is an endogenous polyamine. It is formed from putrescine by spermidine synthase. Spermidine (25 ?M) inhibits the activity of the human inward-rectifying potassium channel Kir2.3 in a patch-clamp assay. It induces autophagy in HeLa cells when used at a concentration of 100 ?M and increases the lifespan of D. melanogaster, yeast, and C. elegans. Spermidine (30 mM in the drinki
价 格:¥电议型 号:T69600产 地:中国大陆
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T6960PU-H71;化合物PU-H71PU-H71
PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM.
价 格:¥电议型 号:T6960产 地:中国大陆
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T69294UK?396082;化合物 UK?396082UK?396082
UK-396082 is a potent inhibitor of thrombin-activated fibrinolytic inhibitor (TAFI), enhancing plasmin activity while concurrently reducing levels of the extracellular matrix (ECM). This compound is valuable for research on chronic kidney disease (CKD).
价 格:¥电议型 号:T69294产 地:中国大陆