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T82603DCAF1 binder 2;化合物 DCAF1 binder 2DCAF1 binder 2
DCAF1 Binder 2, an E3 ligase ligand, is implicated in BRD9, kinase, and selective Bruton´s tyrosine kinase (BTK) degradation.
价 格:¥电议型 号:T82603产 地:中国大陆
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T82602DCI-Br-3;化合物 DCI-Br-3DCI-Br-3
DCI-Br-3 serves as a swift and selective probe with high sensitivity for thiol monitoring in the epileptic brain, exhibiting an excitation wavelength (λex) of 537 nm and an emission wavelength (λem) of 675 nm. It is also capable of efficiently penetrating the blood-brain barrier (BBB) [1].
价 格:¥电议型 号:T82602产 地:中国大陆
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T82600DDAO-C6;化合物 DDAO-C6DDAO-C6
DDAO-C6, a cridone ester derivative, serves as a highly specific fluorescent probe for detecting human serum albumin (HSA). Additionally, it functions as an enzymatically activatable near-infrared fluorescent probe, facilitating the visual detection of endogenous lipase produced by gut microbes (Ex/Em=600/658 nm) [1] [2].
价 格:¥电议型 号:T82600产 地:中国大陆
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T82260Grisnilimab;化合物 GrisnilimabWT1;WT1
"Grisnilimab (WT1), an IgG2a monoclonal antibody targeting CD7, acts as a tumor suppressor in the pathogenesis of Wilms´ tumor. It modulates the transcription of various genes and may be involved in post-transcriptional RNA processing [1]."
价 格:¥电议型 号:T82260产 地:中国大陆
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T81264RLY-2608;化合物 RLY-2608RLY-2608
RLY-2608 is a pioneering, mutant-selective allosteric inhibitor of class IA PI3Kα (phosphoinositide 3-kinase alpha) [1].
价 格:¥电议型 号:T81264产 地:中国大陆
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T81260Rolistobart;化合物 RolistobartRolistobart
Rolistobart is a humanized IgG4-κ monoclonal antibody targeting LILRB4/CD85k. It functions as an immunostimulant and antineoplastic agent [1].
价 格:¥电议型 号:T81260产 地:中国大陆
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T80260Keap1-Nrf2-IN-16;化合物 Keap1-Nrf2-IN-16Keap1-Nrf2-IN-16
Keap1-Nrf2-IN-16 is a biologically active peptide with KEAP1 binding activity.
价 格:¥电议型 号:T80260产 地:中国大陆
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T79260MCI;化合物 MCIMCI
MCI, a chemical compound demonstrating significant anti-inflammatory effects, particularly in collagen-induced arthritis (CIA) models, modulates inflammation through macrophage reprogramming by enhancing ROS scavenging and promoting COX-2 downregulation. It effectively inhibits COX-2, exhibiting an IC50 of 1.23 μM. Additionally, MCI holds potential for research applications in rheumatoid arthritis (RA) [1].
价 格:¥电议型 号:T79260产 地:中国大陆
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T78579NSC260594;化合物 NSC260594NSC260594
NSC260594 is a chemical compound that promotes apoptosis by binding to the shallow groove of the Mcl-1 protein and suppressing its expression through down-regulation of Wnt signaling proteins. Additionally, it can identify the G9-G10-A11-G12 RNA tetraloop of HIV, thereby obstructing the attachment of the Gag protein to the 5’-UTR. This compound demonstrates the potential to impede tumor proliferation and is utilized in the study of Triple-negative breast cancers (TNBCs) [1].
价 格:¥电议型 号:T78579产 地:中国大陆
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T78260Anti-Mouse CD8a Antibody (53-6.7);化合物 Anti-Mouse CD8a Antibody (53-6.7)Anti-Mouse CD8a Antibody (53-
Anti-Mouse CD8a Antibody is a rat-derived IgG2a isotype inhibitor specific for mouse CD8a.
价 格:¥电议型 号:T78260产 地:中国大陆
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T77717AST 7062601;化合物ASTu00A07062601AST070;AST070
AST 7062601 is a potent Ucp1 inducer that promotes endogenous Ucp1 expression in primary mouse brown adipocytes.AST 7062601 may be useful in the study of obesity.
价 格:¥电议型 号:T77717产 地:中国大陆
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T76260Tet-213 TFA;化合物 Tet-213 TFATet-213 TFA
Tet-213 TFA, an antimicrobial peptide, exhibits broad-spectrum antibacterial activity and promotes the repair of infected wounds [1].
价 格:¥电议型 号:T76260产 地:中国大陆
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T75170BI01826025;化合物 BI01826025BI01826025
BI01826025 (pArg-JQ1), a PROTAC degrader targeting the bromodomain 1 of BRDT (BRDT BD1), proves useful in exploring the regulatory impact of ClpC2 on the ClpC1P1P2 protease complex [1].
价 格:¥电议型 号:T75170产 地:中国大陆
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T75013SB26019;化合物 SB26019SB26019
SB26019 is a potent anti-neuroinflammatory compound that modulates the activation of NF-κB by promoting the formation of monomeric α-tubulin. This action of SB26019, in turn, hinders the translocation of p65, signifying its regulatory effect on neuroinflammatory processes [1].
价 格:¥电议型 号:T75013产 地:中国大陆
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T73520TNG260;TNG260TNG260
TNG260 is a CoREST-selective deacetylase ( CoreDAC ) inhibitor. TNG260 inhibits HDAC1 with 10-fold selectivity over HDAC3 . TNG260 leads to HDAC1 inhibition, reverses anti-PD1 resistance driven by loss of STK11. TNG260 decreases intratumoral infiltration of neutrophils. TNG260 exhibits immune-mediated cell killing [1] .
价 格:¥电议型 号:T73520产 地:中国大陆
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T72608VEGFR-2/BRAF-IN-2;化合物 VEGFR-2/BRAF-IN-2VEGFR-2/BRAF-IN-2
VEGFR-2/BRAF-IN-2, as a dual VEGFR-2 and BRAF kinase inhibitor, exhibits potent IC50 values of 0.111 ?M, 0.089 ?M, and 0.071 ?M against VEGFR-2, BRAF V600E, and BRAF WT, respectively. This compound effectively induces apoptosis and predominantly arrests the cell cycle in the G1 phase.
价 格:¥电议型 号:T72608产 地:中国大陆
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T72607VEGFR-2/BRAF-IN-1;化合物 VEGFR-2/BRAF-IN-1VEGFR-2/BRAF-IN-1
VEGFR-2/BRAF-IN-1, a dual inhibitor of VEGFR-2 and BRAF kinases, demonstrates potent inhibitory activity with IC50 values of 0.049 ?M for VEGFR-2, 0.063 ?M for BRAF V600E, and 0.005 ?M for BRAF WT. It effectively induces apoptosis and arrests the cell cycle primarily at the G1/S phase.
价 格:¥电议型 号:T72607产 地:中国大陆
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T72606AT1R antagonist 1;化合物 AT1R antagonist 1AT1R antagonist 1
AT1R Antagonist 1 (compound 10) serves as a potent, selective ligand for AT1R with considerable affinity, demonstrated by a K i value of 8.5 nM [1].
价 格:¥电议型 号:T72606产 地:中国大陆
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T72605C-RAF kinase-IN-1;化合物 C-RAF kinase-IN-1C-RAF kinase-IN-1
C-RAF kinase-IN-1 is a potent inhibitor of C-RAF kinase with an IC 50 of 0.193 μM. C-RAF kinase-IN-1 is a quinoline derivative. C-RAF kinase-IN-1 has the potential for the research of cancer diseases [1] .
价 格:¥电议型 号:T72605产 地:中国大陆