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T4327Prexasertib dihydrochloride；化合物Prexasertib dihydrochlorideLY2606368 (dihydrochloride)|||Prexasertib
Prexasertib dihydrochloride (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respectively.
价 格：￥电议型 号：T4327产 地：中国大陆
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T4310L2Prexasertib mesylate；化合物 T4310L2LY-2606368|||LY2606368|||LY 2606368；LY-2606368|||LY2606368|||LY 2606
Prexasertib is a potent and selective Chk1/Chk2 inhibitor. Prexasertib increases the effectiveness of conventional therapy in B-/T- cell progenitor acute lymphoblastic leukemia. LY2606368 causes replication catastrophe and antitumor effects through CHK1-dependent mechanisms. Treatment of cells with LY2606368 results in the rapid appearance of TUNEL and pH2AX-positive double-stranded DNA breaks in the S-phase cell population.
价 格：￥电议型 号：T4310L2产 地：中国大陆
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T4310LPrexasertib lactate hydrate；化合物 T4310LPrexasertib monolactate monohydrate|||LY-2606368|||LY 2606368|
Prexasertib is an effective and selective Chk1/Chk2 inhibitor. Prexasertib causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms.
价 格：￥电议型 号：T4310L产 地：中国大陆
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T4310Prexasertib；化合物PrexasertibLY2606368；5-[[5-[2-(3-氨基丙氧基)-6-甲氧基苯基]-1H-吡唑-3-基]氨基]-2-吡嗪甲腈|||LY2606368
Prexasertib (LY2606368) is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity.
价 格：￥电议型 号：T4310产 地：中国大陆
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T4260Capmatinib 2HCl；INCB28060盐酸盐INC-280 2HCl|||INCB28060 2HCl；INC-280 2HCl|||INCB28060盐酸盐|||INCB28060 2H
Capmatinib 2HCl (INC-280 2HCl) is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.Capmatinib 2HCl exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines. As a result, Capmatinib 2HCl potently inhibits c-MET-dependent tumor cell proliferation a
价 格：￥电议型 号：T4260产 地：中国大陆
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T4221PF-06260933；化合物PF6260933PF-6260933|||PF 6260933|||PF6260933；PF-6260933|||PF 6260933|||PF6260933
PF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM for kinase and cell, respectively.
价 格：￥电议型 号：T4221产 地：中国大陆
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T41260SC144 hydrochloride；化合物 SC144 hydrochlorideSC144 hydrochloride
SC144 hydrochloride, a first-in-class, orally active, small-molecule gp130 (IL6-beta) inhibitor, demonstrates potent inhibition of gp130 ligand-triggered signaling. By binding to gp130, it initiates gp130 phosphorylation (S782) and deglycosylation, impedes Stat3 phosphorylation and nuclear translocation, and suppresses the expression of downstream target genes. Furthermore, SC144 hydrochloride effectively induces apoptosis in human ovarian cancer cells [1].
价 格：￥电议型 号：T41260产 地：中国大陆
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T40594iHCK-37；iHCK-37iHCK-37|||ASN05260065；iHCK-37|||ASN05260065
iHCK-37 (ASN05260065) is a high-potency, selective inhibitor of Hck with a Ki value of 0.22 μM. It effectively inhibits HIV-1 viral replication, exhibiting an EC50 value of 12.9 μM. Primarily employed in chronic myeloid leukemia (CML) research, iHCK-37 demonstrates promising potential for studying and understanding this disease.
价 格：￥电议型 号：T40594产 地：中国大陆
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T40260β-Secretase Inhibitor II；β-Secretase Inhibitor IIβ-Secretase Inhibitor II
β-Secretase Inhibitor II is a tripeptide aldehyde compound that acts as an inhibitor of β-Secretase. It exhibits a simple structure and has an inhibitory potency of IC50 = 700 nM against total Aβ and IC50 = 2.5 μM specifically against Aβ 1-42. This compound is particularly useful in research related to Alzheimer´s disease.
价 格：￥电议型 号：T40260产 地：中国大陆
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T39260Fmoc-Gln(Trt)-Ser(psi(Me,Me)pro)-OH；Fmoc-Gln(Trt)-Ser(psi(Me,Me)pro)-OHFmoc-Gln(Trt)-Ser(psi(Me,Me)p
Fmoc-Gln(Trt)-Ser(psi(Me,Me)pro)-OH is a dipeptide.
价 格：￥电议型 号：T39260产 地：中国大陆
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T38620Prexasertib dimesylate；Prexasertib dimesylateLY2606368 dimesylate；LY2606368 dimesylate
Prexasertib dimesylate (LY2606368 dimesylate) is a highly selective ATP-competitive second-generation inhibitor of checkpoint kinase 1 (CHK1). With a K i of 0.9 nM and an IC 50 of <1 nM, Prexasertib dimesylate effectively inhibits CHK2 (IC 50 = 8 nM) and RSK1 (IC 50 = 9 nM). Its mechanism of action involves inducing double-stranded DNA breakage and replication catastrophe, ultimately leading to apoptosis. Moreover, Prexasertib dimesylate demonstrates potent anti-tumor activity.
价 格：￥电议型 号：T38620产 地：中国大陆
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T38260SP 600125, negative control；SP 600125阴性对照JNK Inhibitor II, negative control；JNK Inhibitor II, negati
SP 600125, negative control is a methylated analog of SP 600125 and can be used as a negative control for SP 600125. SP 600125, negative control inhibits DTP3 and GADD45β/MKK7 (growth arrest and DNA damage-inducible β/mediator-activated protein kinase kinase kinase 7) and is capable of restoring activation.The IC50s of SP 600125, negative control against JNK2 and JNK3 were 18 and 24 μM, respectively.
价 格：￥电议型 号：T38260产 地：中国大陆
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T38107JJH260；JJH260JJH260；JJH260
JJH260 is an N-hydroxy hydantoin carbamate that inhibits androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). It blocks the hydrolysis of 9-PAHSA with an IC50 value of 0.57 μM. JJH260 also inhibits the novel FAHFA hydrolase androgen-dependent TFPI-regulating protein (ADTRP; IC50 = 8.5 μM), as well as the serine hydrolase ABHD6 and the lysophospholipases LYPLA1 and LYPLA2. JJH260 inhibits the FAHFA hydrolase activity of LNCaP and T cell lysa
价 格：￥电议型 号：T38107产 地：中国大陆
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T3726014,15-dehydro Leukotriene B4；14,15-dehydro Leukotriene B414,15-dehydro Leukotriene B4；14,15-dehydro
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. At least two LTB4 receptors, termed BLT1 and BLT2, have been identified. 14,15-dehydro LTB4 is a LTB4 receptor antagonist that has a higher binding affinity for BLT1, demonstrating a Ki value
价 格：￥电议型 号：T37260产 地：中国大陆
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T36260NR 7h；NR 7hNR 7h
Potent and selective p38α and p38β degrader (DC50 < 50 nM). Displays no significant degradation of p38γ, p38δ, JNK1/2 or ERK1/2. Inhibits phosphorylation of MK2 in UV-treated cancer cells and LPS-stimulated bone marrow-derived macrophages (BMDM). Exhibits similar effect to p38α gene knockout in BBL358 cells. Active in vivo.
价 格：￥电议型 号：T36260产 地：中国大陆
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T36016PF 06260933 dihydrochloride；PF 06260933 dihydrochloridePF 06260933 dihydrochloride
MAP4K4 (HGK) inhibitor (IC50 = 140 nM). Also inhibits MINK and TNIK (IC50 values are 8 and 13 nM, respectively). Improves fasting hyperglycemia in mice. Orally active.
价 格：￥电议型 号：T36016产 地：中国大陆
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T35874CC260；CC260CC260
CC260, a selective inhibitor for PI5P4Kα and PI5P4Kβ with Kis of 40 nM and 30 nM respectively, exhibits minimal to no inhibition against other protein kinases like Plk1 and RSK2. It is applicable in the research of cell energy metabolism, diabetes, and cancer[1].
价 格：￥电议型 号：T35874产 地：中国大陆
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T35362NSC622608；化合物NSC622608NSC622608
NSC622608 is a small-molecule ligand for V-domain Ig suppressor of T-cell activation (VISTA) which is an immune checkpoint that affects the ability of T-cells to attack tumors.
价 格：￥电议型 号：T35362产 地：中国大陆
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T35311ZM 260384；化合物 T35311ZM260384|||ZM-260384；ZM260384|||ZM-260384
ZM 260384 is a potassium channel opener.
价 格：￥电议型 号：T35311产 地：中国大陆
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T35260YM 22508；化合物 T35260YM22508|||YM-22508；YM22508|||YM-22508
YM 22508 is a biochemical.
价 格：￥电议型 号：T35260产 地：中国大陆
