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  • T74485STC314；化合物 STC314STC314

    STC314 is an anti-infective agent that reverses organ damage caused by excessive immune response by neutralizing extracellular histones and neutrophil trapping networks, and can be used in the study of sepsis and acute respiratory distress syndrome (ARDS).STC314 protects the stability of lipid bilayers, and inhibits platelet activation and erythrocyte damage.STC314 is also used in the study of prostate cancer.Nardeterol HCl is a selective kappa agonist with analgesic activity.

    价 格：￥电议型 号：T74485产 地：中国大陆

  • T7431414:1 EPC trifluoromethanesulfonate；化合物 14:1 EPC trifluoromethanesulfonate14:1 EPC trifluoromethanesu

    14:1 EPC trifluoromethanesulfonate, an ethyl-phosphatidylcholine (EPC) derivative with monounsaturated 14:1 chains, exhibits transfection activity. This compound is utilized for drug delivery [1] [2].

    价 格：￥电议型 号：T74314产 地：中国大陆

  • T7352Pridopidine；4-[3-(甲磺酰基)苯基]-1-丙基哌啶ACR16|||ASP2314|||FR310826；ACR16|||ASP2314|||FR310826|||4-[3-(甲磺酰基)

    Pridopidine (FR310826), a dopamine (DA) stabilizer, acts as a low affinity dopamine D2 receptor (D2R) antagonist, improves motor performance and shows neuroprotective effects in Huntington disease R6/2 mouse model.

    价 格：￥电议型 号：T7352产 地：中国大陆

  • T73314(R)-ZG197；化合物 (R)-ZG197(R)-ZG197

    (R)-ZG197 is a compound that acts as a highly selective activator for Staphylococcus aureus Caseinolytic protease P (Sa ClpP), exhibiting an effective concentration (EC50) of 1.5 μM. It also activates Homo sapiens ClpP (Hs ClpP) with an EC50 of 31.4 μM.

    价 格：￥电议型 号：T73314产 地：中国大陆

  • T73149HPK1-IN-33；化合物 HPK1-IN-33HPK1-IN-33

    HPK1-IN-33 (compound 21), a Hematopoietic Progenitor Kinase 1 (HPK1) inhibitor, exhibits a high potency with a K_i of 1.7 nM. It effectively inhibits IL-2 production, demonstrating EC_50 values of 286 nM in Jurkat WT cells and >10000 nM in Jurkat HPK1 KO cells [1].

    价 格：￥电议型 号：T73149产 地：中国大陆

  • T73148ACT-777991；化合物 ACT-777991ACT-777991

    ACT-777991 is an orally active, selective CXCR3 antagonist with demonstrated stability in microsomes and hepatocytes across various animal models. This compound effectively inhibits the migration of activated T cells toward CXCL11.

    价 格：￥电议型 号：T73148产 地：中国大陆

  • T73146FGFR3-IN-5；化合物 FGFR3-IN-5FGFR3-IN-5

    FGFR3-IN-5 is a potent, selective FGFR3 inhibitor, exhibiting IC50 values of 3 nM (FGFR3), 44 nM (FGFR2), and 289 nM (FGFR1), respectively. This compound is utilized in cancer research.

    价 格：￥电议型 号：T73146产 地：中国大陆

  • T73145FGFR3-IN-4；化合物 FGFR3-IN-4FGFR3-IN-4

    FGFR3-IN-4 is a selective inhibitor targeting FGFR3, demonstrating an IC50 value of under 50 nM. This compound exhibits at least a tenfold greater selectivity for FGFR3 compared to FGFR1.

    价 格：￥电议型 号：T73145产 地：中国大陆

  • T73143PHGDH-IN-3；化合物PHGDH-IN-3PHGDH-IN-3

    PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.8 μM against PHGDH. PHGDH-IN-3 can be used in studies about cancer.

    价 格：￥电议型 号：T73143产 地：中国大陆

  • T73142FLT3-IN-18；化合物 FLT3-IN-18FLT3-IN-18

    FLT3-IN-18, a potent and selective FLT3 inhibitor, exhibits an IC50 value of 0.003 μM. It effectively induces apoptosis and G1 phase cell cycle arrest, while inhibiting FLT3 and STAT5 phosphorylation. This compound holds potential for acute myeloid leukemia (AML) research.

    价 格：￥电议型 号：T73142产 地：中国大陆

  • T73141GSK1790627；化合物 GSK1790627GSK1790627

    GSK1790627, the N-deacetylated metabolite of Trametinib, represents an orally active MEK inhibitor that promotes autophagy and triggers apoptosis [1].

    价 格：￥电议型 号：T73141产 地：中国大陆

  • T73140MAT2A-IN-9；化合物MAT2A-IN-9MAT2A-IN-9

    MAT2A-IN-9, a 2-oxoquinazoline derivative, is a potent MAT2A (methionine adenylyltransferase 2A) inhibitor.MAT2A-IN-9 has antitumor activity for the treatment of lymphomas and solid tumors.

    价 格：￥电议型 号：T73140产 地：中国大陆

  • T72314α-Synuclein inhibitor 8；化合物 α-Synuclein inhibitor 8α-Synuclein inhibitor 8

    α-Synuclein inhibitor 8 effectively impedes α-Synuclein aggregation and disaggregation with an IC50 of 2.5 ?M, demonstrating substantial reduction in neuronal inclusion formation, which contributes to reparative effects in damaged neurons and symptomatic improvement in Parkinson’s disease (PD)-like models. The compound also exhibits high antioxidant activity and low cytotoxicity [1].

    价 格：￥电议型 号：T72314产 地：中国大陆

  • T71420RO314724；化合物 RO314724RO314724

    RO314724 is a HDAC inhibitor. RO314724 is also a a reversible, tightly binding, MMP inhibitor with a Ki of 26 nm. Matrix metalloproteinases (MMPs) belong to the key enzymes of the proteolytic destruction of cartilage matrix during chronic rheumatic diseases. Ro314724 displayed MMP-proteoglycanase inhibitory activity both in vitro and ex vivo and proved to be not harmful to the morphology, viability and proteoglycan biosynthesis of bovine articular cartilage explants.

    价 格：￥电议型 号：T71420产 地：中国大陆

  • T71314GL-V9；化合物 GL-V9GL-V9

    GL-V9 is an AMPK activator, protecting against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy.

    价 格：￥电议型 号：T71314产 地：中国大陆

  • T71062Kri 1314；化合物 Kri 1314Kri 1314

    Kri 1314 is a cyclohexyl-norstatine-containing dipeptide renin inhibitor which has potential for the treatment of hypertension.

    价 格：￥电议型 号：T71062产 地：中国大陆

  • T70314GW297361X；化合物 GW297361XGW297361X

    GW297361X is an inhibitor of active Vaccinia-Related Kinases (VRK).

    价 格：￥电议型 号：T70314产 地：中国大陆

  • T70071SLM6031434 (free base)；化合物 SLM6031434 (free base)SLM6031434 (free base)

    SLM6031434 (free base) is an inhibitor of sphingosine kinase type 2 (SphK2). It consists of pedant 1-guanidino-2-phenyloxadiazolylpyrrolidine group.

    价 格：￥电议型 号：T70071产 地：中国大陆

  • T69936NK314；化合物 NK314NK314

    NK314 is a novel synthetic benzo[c]phenanthridine alkaloid that shows strong antitumor activity. It inhibited topoisomerase II activity and stabilized topoisomerase II-DNA cleavable complexes. The DNA breaks occurred within 1h after treatment with NK314 even without digestion of topoisomerase II by proteinase K, whereas etoposide required digestion of the enzyme protein in cleavable complex to detect DNA breaks. Pretreatment with topoisomerase II catalytic inhibitors, ICRF-193 and suramin, reduc

    价 格：￥电议型 号：T69936产 地：中国大陆

  • T69739BI-0314；化合物 BI-0314BI-0314

    BI-0314 is a selective allosteric STEP activator.

    价 格：￥电议型 号：T69739产 地：中国大陆

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