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  • T7417Avatrombopag；化合物AvatrombopagYM477|||AKR-501|||E5501；YM477|||AKR-501|||1-[3-氯-5-[[[4-(4-氯-2-噻吩基)-5-(4

    Avatrombopag (YM477) is a new oral thrombopoietin (TPO) receptor agonist, activating TPO receptor and increasing megakaryocytic proliferation/differentiation and platelet production.

    价 格：￥电议型 号：T7417产 地：中国大陆

  • T73477SHP844；化合物 SHP844SHP844

    SHP844, a SHP2 inhibitor, exhibits an IC50 value of 18.9 ?M. SHP2, a protein tyrosine phosphatase (PTP), plays a crucial role in modulating tyrosine phosphorylation levels, thereby influencing cell proliferation, differentiation, and survival.

    价 格：￥电议型 号：T73477产 地：中国大陆

  • T73437DP00477；化合物 DP00477DP00477

    DP00477, a potent inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1), exhibits an inhibitory concentration (IC50) of 7.0 ?M. This compound holds promise for cancer research applications.

    价 格：￥电议型 号：T73437产 地：中国大陆

  • T71951AS-1940477 hydrobromide；化合物 AS-1940477 hydrobromideAS-1940477 hydrobromide

    AS-1940477 hydrobromide is a p38 mitogen-activated protein kinase (MAPK) inhibitor.

    价 格：￥电议型 号：T71951产 地：中国大陆

  • T71477CP4d inhibitor；化合物 CP4d inhibitorCP4d inhibitor

    CP4d is a novel reversible tg2 transamidase site-specific inhibitor

    价 格：￥电议型 号：T71477产 地：中国大陆

  • T70652SAR-104772；化合物 SAR-104772SAR-104772

    SAR-104772 is a novel inhibitor of TAFIa (activated thrombin-activatable fibrinolysis inhibitor).

    价 格：￥电议型 号：T70652产 地：中国大陆

  • T70477SC 53228；化合物 SC 53228SC 53228

    SC 53228 is a specific leukotriene B4 receptor antagonist.

    价 格：￥电议型 号：T70477产 地：中国大陆

  • T69780VU6007477；化合物 VU6007477VU6007477

    VU6007477 is a novel M1 PAM. VU6007477 resulted in good rat M1 PAM potency (EC50 = 230 nM, 93% ACh max), minimal M1 agonist activity (agonist EC50 > 10 μM), good CNS penetration (rat brain/plasma Kp = 0.28, Kp,uu = 0.32; mouse Kp = 0.16, Kp,uu = 0.18), and no cholinergic adverse events (AEs, e.g., seizures).

    价 格：￥电议型 号：T69780产 地：中国大陆

  • T69612PSB-KD477；化合物 PSB-KD477PSB-KD477

    PSB-KD477 is an Agonist of the Cannabinoid-Activated Orphan G-Protein-Coupled Receptor GPR18. PSB-KD477 displayed significantly higher potency and efficacy than THC, determined in a GPR18-dependent β-arrestin recruitment assay, and were found to be selective versus the CB-sensitive receptors CB1, CB2, and GPR55. Structure-activity relationships were steep, and indole substitution was crucial for biological activity. These first selective agonists, which are structurally distinct from the lipidic

    价 格：￥电议型 号：T69612产 地：中国大陆

  • T69477F81-1144b；化合物 F81-1144bF81-1144b

    F81-1144b is a matrix metalloproteinase inhibitor which reduces secretion of very low density lipoprotein-triacylglycerol, thereby lowering TAG levels in serum and the liver. F81-1144b also lowers VLDL-TAG secretion, de novo FA synthesis in the liver, and serum levels of insulin and glucose.

    价 格：￥电议型 号：T69477产 地：中国大陆

  • T69438MT477；化合物 MT477MT477

    MT477 is PKC-α inhibitor. MT477 interfered with PKC activity as well as phosphorylation of Ras and ERK1/2 in H226 human lung carcinoma cells. It also induced poly-caspase-dependent apoptosis. MT477 had a dose-dependent (0.006 to 0.2 mM) inhibitory effect on cellular proliferation of H226, MCF-7, U87, LNCaP, A431 and A549 cancer cell lines as determined by in vitro proliferation assays.

    价 格：￥电议型 号：T69438产 地：中国大陆

  • T68532ICI-147798 HCl；化合物 ICI-147798 HClICI-147798 HCl

    ICI-147798 HCl is a beta adrenoceptor antagonist.

    价 格：￥电议型 号：T68532产 地：中国大陆

  • T68477XL-418；化合物 XL-418XL-418

    XL-418 is a selective, orally active small molecule, targeting protein kinase B (PKB or AKT) and ribosomal protein S6 Kinase (p70S6K), with potential antineoplastic activity. XL418 inhibits the activities of PKB and p70S6K, both acting downstream of phosphoinosotide-3 kinase (PI3K). These kinases are often upregulated in a variety of cancers. Inhibition of PKB by this agent will induce apoptosis, while inhibition of p70S6K will result in the inhibition of translation within tumor cells.

    价 格：￥电议型 号：T68477产 地：中国大陆

  • T68321AS1940477；化合物 AS1940477AS1940477

    AS1940477 is p38 MAPK inhibitor. AS1940477 inhibited the enzymatic activity of recombinant p38α and β isoforms but showed no effect against other 100 protein kinases including p38γ and δ isoforms. In human peripheral blood mononuclear cells, AS1940477 inhibited lipopolysaccharide (LPS)- or phytohemagglutinin A (PHA)-induced production of proinflammatory cytokines, including TNFα, IL-1β, and IL-6 at low concentrations (LPS/TNFα, IC(50)=0.45n M; PHA/TNFα, IC(50)=0.40 nM). In addition, equivalent c

    价 格：￥电议型 号：T68321产 地：中国大陆

  • T6727VU0364770；化合物VU 0364770VU 0364770；VU 0364770

    VU0364770 (VU 0364770)(EC50=1.1 μM), a positive allosteric modulator(PAM) of mGlu4, shows insignificant activity at 68 other receptors, including other mGlu subtypes.

    价 格：￥电议型 号：T6727产 地：中国大陆

  • T66477(2S,3R,4S,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyra

    (2S,3R,4S,5S,6R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol is a useful organic compound for research related to life sciences. The catalog number is T66477 and the CAS number is 714269-57-5.

    价 格：￥电议型 号：T66477产 地：中国大陆

  • T65477Boc-Phe(4-Cl)-OH；化合物 Boc-Phe(4-Cl)-OHBoc-Phe(4-Cl)-OH

    Boc-Phe(4-Cl)-OH is an amino acid derivative and has a wide range of applications in life science related research.

    价 格：￥电议型 号：T65477产 地：中国大陆

  • T64779Cypate；化合物 3-(2-(7-(3-(2-Carboxyethyl)-1,1-dimethyl-1H-benzo[e]indol-3-ium-2-yl)hepta-2,4,6-trien-1-

    3-(2-(7-(3-(2-Carboxyethyl)-1,1-dimethyl-1H-benzo[e]indol-3-ium-2-yl)hepta-2,4,6-trien-1-ylidene)-1,1-dimethyl-1,2-dihydro-3H-benzo[e]indol-3-yl)propanoate is a useful organic compound for research related to life sciences and the catalog number is T64779.

    价 格：￥电议型 号：T64779产 地：中国大陆

  • T647782-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine；化合物 2-(2-((tert-Butyldimethylsilyl)oxy)ethox

    2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine is a useful organic compound for research related to life sciences and the catalog number is T64778.

    价 格：￥电议型 号：T64778产 地：中国大陆

  • T64777Agar；化合物 AgarAgar

    Agar has a wide range of applications in life science related research.

    价 格：￥电议型 号：T64777产 地：中国大陆

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