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T73063Rostratin B;化合物 Rostratin BRostratin B
Rostratin B, a cytotoxic disulfide, demonstrates in vitro cytotoxicity against human colon carcinoma (HCT-116), exhibiting an IC50 value of 1.9 μg/mL.
价 格:¥电议型 号:T73063产 地:中国大陆
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T72237JBJ-09-063 hydrochloride;化合物 JBJ-09-063 hydrochlorideJBJ-09-063 hydrochloride
JBJ-09-063 hydrochloride is an EGFR inhibitor selective for mutants, demonstrating IC50 values of 0.147 nM, 0.063 nM, 0.083 nM, and 0.396 nM against EGFR L858R, EGFR L858R/T790M, EGFR L858R/T790M/C797S, and EGFR L747S, respectively. It effectively inhibits EGFR, Akt, and ERK1/2 phosphorylation, showing efficacy in both EGFR tyrosine kinase inhibitor (TKI)-sensitive and -resistant models. This compound holds potential for research on EGFR-mutant lung cancer.
价 格:¥电议型 号:T72237产 地:中国大陆
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T72063PDCD4-IN-1;化合物PDCD4-IN-1PDCD4-IN-1
PDCD4-IN-1, a PDCD4 inhibitor (Kd : 350 nM), promotes BDNF expression in hippocampal neuronal cells HT-22.
价 格:¥电议型 号:T72063产 地:中国大陆
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T71924AVE-8063;化合物 AVE-8063AVE-8063
AVE-8063 is an antimitotic agent or microtubule inhibitor with potential anticancer activity.
价 格:¥电议型 号:T71924产 地:中国大陆
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T71321(S)-VU0637120;化合物 (S)-VU0637120(S)-VU0637120
(S)-VU0637120 is a selective neuropeptide Y(4)R-mutant antagonist used in the study of metabolic disorders.
价 格:¥电议型 号:T71321产 地:中国大陆
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T71063Tolytoxin;化合物 TolytoxinTolytoxin
Tolytoxin is a cytostatic, antifungal macrolide produced by blue-green algae of the genus Scytonema, is a potent, reversible inhibitor of cytokinesis in cultured mammalian cells
价 格:¥电议型 号:T71063产 地:中国大陆
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T70839S 14063;化合物 S 14063S 14063
S 14063 is a potent 5-HT1A receptor antagonist devoid of beta-adrenoceptor blocking properties.
价 格:¥电议型 号:T70839产 地:中国大陆
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T70639AM-9514;化合物 AM-9514AM-9514
AM-9514 is a novel, potent Glucokinase (GK) activator. AM-9514 showed a favorable combination of in vitro potency, enzyme kinetic properties, acceptable pharmacokinetic profiles in preclinical species, and robust efficacy in a rodent PD model. Glucokinase (GK) activators represent a class of type 2 diabetes therapeutics actively pursued due to the central role that GK plays in regulating glucose homeostasis.
价 格:¥电议型 号:T70639产 地:中国大陆
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T70638p38-α MAPK-IN-5;化合物 CHF-6297p38-α MAPK-IN-5
P38-α MAPK-IN-5 is a potent inhibitor of p38α, demonstrating inhibitory concentrations (IC50) of 0.1 nM for p38α, 0.2 nM for p38β, 944 nM for p38γ, and 4100 nM for p38δ. It exhibits anti-inflammatory properties and holds potential for research in asthma and chronic obstructive pulmonary disease (COPD).
价 格:¥电议型 号:T70638产 地:中国大陆
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T70637FRAN-12;化合物 FRAN-12FRAN-12
FRAN-12 is a histamine and 5-hydroxytryptamine antagonist with pressor properties.
价 格:¥电议型 号:T70637产 地:中国大陆
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T70636XAN35021;化合物 XAN35021XAN35021
XAN35021, also known as ROMK inhibitor 25, or ROMK-IN-25, is a potent and selective ROMK inhibitor with improved pharmacokinetic properties. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
价 格:¥电议型 号:T70636产 地:中国大陆
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T70634Psycholeine;化合物 PsycholeinePsycholeine
Psycholeine is isolated from the tropical plant Psychotria oleoides; exhibits somatostatin antagonistic activity on growth hormone secretion.
价 格:¥电议型 号:T70634产 地:中国大陆
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T70633GR-92549;化合物 GR-92549GR-92549
GR-92549 is an HMG-CoA reductase inhibitor.
价 格:¥电议型 号:T70633产 地:中国大陆
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T70632DFL23448;化合物 DFL23448DFL23448
DFL23448 is a TRPM8-selective ion channel antagonist, modifying bladder function and reduces bladder overactivity in awake rats.
价 格:¥电议型 号:T70632产 地:中国大陆
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T70631GKL-003;化合物 GKL-003GKL-003
GKL-003 is an inhibitor of Bacterial Transcription Initiation Complex formation.
价 格:¥电议型 号:T70631产 地:中国大陆
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T70630Dichlorodenafil;化合物 DichlorodenafilDichlorodenafil
Dichlorodenafil is an inhibitor of phosphodiesterase type 5 enzyme (PDE-5).
价 格:¥电议型 号:T70630产 地:中国大陆
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T70485Exp 063;化合物 Exp 063Exp 063
Exp 063 is a hybrid compound that possesses both the angiotensin II antagonist activity and the β-blocking activity. EXP 063 also acts as a partial β-agonist.
价 格:¥电议型 号:T70485产 地:中国大陆
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T70363PF-06371900;化合物 PF-06371900PF-06371900
PF-06371900 is a potent and highly selective inhibitor of leucine-rich repeat kinase 2 (LRRK2).
价 格:¥电议型 号:T70363产 地:中国大陆
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T70063GYKI 52466 HCl;化合物 GYKI 52466 HClGYKI 52466 HCl
GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 ?M) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 ?M but also inhibits kainate-induced inward currents in the same cells (IC50 = 11 ?M).2 GYKI 52466 (10 ?M) reduces the amplitude of spontaneous excitatory postsynaptic currents (EPSCs) in the same cells. It increases the latency to seizure onset and reduces mortality in a rat model of general
价 格:¥电议型 号:T70063产 地:中国大陆