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  • T77638BIRM 271；化合物BIRM 271BIRM 271

    BIRM 271 is a novel arachidonic acid release inhibitor that blocks leukotriene B4 and platelet-activating factor biosynthesis in human neutrophils. BIRM 271 and BIRM 270 are enantiomers that inhibit the production of leukotriene B4 with IC50 of 40 nM.

    价 格：￥电议型 号：T77638产 地：中国大陆

  • T7749ALB-127158；化合物 T7749ALB-127158

    ALB-127158(a) is a potent and selective melanin concentrating hormone 1 ( MCH 1 ) receptor antagonist which may be a potential treatment for inflammatory bowel disease (IBD).

    价 格：￥电议型 号：T7749产 地：中国大陆

  • T772716-Bromohexyl 2-hexyldecanoate；化合物 6-Bromohexyl 2-hexyldecanoate6-Bromohexyl 2-hexyldecanoate

    6-Bromohexyl 2-hexyldecanoate, a lipid, serves as a precursor in the synthesis of lipid nanoparticles and nanomaterials [1].

    价 格：￥电议型 号：T77271产 地：中国大陆

  • T76271Hepcidin-25 (human)；化合物 Hepcidin-25 (human)Hepcidin-25 (human)

    Hepcidin-25 (human), an iron metabolism modulator, exhibits both anti-inflammatory and antibacterial activity through the modulation of iron-mediated oxidant injury [1].

    价 格：￥电议型 号：T76271产 地：中国大陆

  • T75271L-Pyroglutamic acid sodium；化合物 L-Pyroglutamic acid sodiumL-Pyroglutamic acid sodium

    Sodium L-pyroglutamate is a biochemical reagent utilized as a biological material or organic compound in life science research.

    价 格：￥电议型 号：T75271产 地：中国大陆

  • T74271TRIM24/BRPF1-IN-2；化合物 TRIM24/BRPF1-IN-2TRIM24/BRPF1-IN-2

    TRIM24/BRPF1-IN-2 (compound 20l) is an effective dual inhibitor of TRIM24/BRPF1, demonstrating IC50 values of 0.98 μM for TRIM24 and 1.16 μM for BRPF1, respectively. It exhibits strong binding affinity to the bromodomains of TRIM24/BRPF1, making it a valuable tool for prostate cancer research [1].

    价 格：￥电议型 号：T74271产 地：中国大陆

  • T73271MMV688845；化合物 MMV688845(R)-GSK1729177A；(R)-GSK1729177A

    MMV688845 is a bactericidal nontuberculous mycobacteria (NTM) RNA polymerase inhibitor that exhibits anti-tuberculosis efficacy and is effective against Mycobacterium abscessus.

    价 格：￥电议型 号：T73271产 地：中国大陆

  • T72719Tubulin/MMP-IN-2；化合物 Tubulin/MMP-IN-2Tubulin/MMP-IN-2

    Tubulin/MMP-IN-2, a dual inhibitor of tubulin and matrix metalloproteinases (MMPs), effectively inhibits tubulin polymerization and induces cell apoptosis. It demonstrates inhibitory activities against MMP-2, MMP-3, and MMP-9, with IC50 values of 24.95 μM, 31.60 μM, and 22.37 μM, respectively. This compound is utilized in cancer research.

    价 格：￥电议型 号：T72719产 地：中国大陆

  • T72718SARS-CoV-2-IN-36；化合物 SARS-CoV-2-IN-36SARS-CoV-2-IN-36

    SARS-CoV-2-IN-36 is a potent inhibitor of SARS-CoV-2 Mpro (SARS-CoV), demonstrating an IC50 of 2.37 μM and a Kd of 1.19 μM in enzymatic assays. This compound exhibits antiviral activity against SARS-CoV-2 variants UC-1074, RG2674, and NVDBB-2220 in Vero cells.

    价 格：￥电议型 号：T72718产 地：中国大陆

  • T72717Anti-IAV agent 1；化合物 Anti-IAV agent 1Anti-IAV agent 1

    Anti-IAV Agent 1-1a is an orally administered compound effective against the Influenza A virus (IAV), demonstrating inhibitory concentration 50 (IC50) values of 0.03 μM and 0.06 μM for the H1N1 strain and the Oseltamivir-resistant H1N1 strain of IAV, respectively.

    价 格：￥电议型 号：T72717产 地：中国大陆

  • T72715JNK3 inhibitor-4；化合物 JNK3 inhibitor-4JNK3 inhibitor-4

    JNK3 Inhibitor-4, a potent 2-aryl-1-pyrimidinyl-1H-imidazole-5-yl acetonitrile derivative, demonstrates a strong inhibitory effect on JNK3 with an IC 50 value of 1.0 nM. It exhibits exceptional selectivity against JNK3 when compared to other protein kinases, including isoforms JNK1 (IC 50 = 143.9 nM) and JNK2 (IC 50 = 298.2 nM). Additionally, JNK3 Inhibitor-4 benefits from neuroprotective properties and is predicted to permeate the blood-brain barrier effectively.

    价 格：￥电议型 号：T72715产 地：中国大陆

  • T72714JNK3 inhibitor-3；化合物 JNK3 inhibitor-3JNK3 inhibitor-3

    JNK3 Inhibitor-3 (compound 15g) is a selective, blood-brain barrier permeable, and orally active inhibitor of c-Jun N-terminal kinase 3 (JNK3) with IC50 values of 147.8 nM, 44.0 nM, and 4.1 nM against JNK1, JNK2, and JNK3, respectively. This compound has been shown to significantly enhance memory in mouse models of dementia and is utilized in Alzheimer’s disease research [1].

    价 格：￥电议型 号：T72714产 地：中国大陆

  • T72713PI3K/VEGFR2-IN-1；化合物 PI3K/VEGFR2-IN-1PI3K/VEGFR2-IN-1

    PI3K/VEGFR2-IN-1 is a potent dual inhibitor targeting both PI3K and VEGFR2 with IC50 values of 2.21 μM for PI3K and 68 μM for VEGFR2, respectively. This compound also induces apoptosis and is utilized in cancer research [1].

    价 格：￥电议型 号：T72713产 地：中国大陆

  • T71864SJ572710；化合物 SJ572710SJ572710

    SJ572710 is an inhibitor of the disordered protein, p27(Kip1).

    价 格：￥电议型 号：T71864产 地：中国大陆

  • T7130Navarixin；化合物NavarixinMK-7123|||SCH 527123；MK-7123|||SCH 527123

    Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil trafficking in animal models, characteristics that may be beneficial in the treatment of conditions with unbalanced pulmonary neutrophilia.

    价 格：￥电议型 号：T7130产 地：中国大陆

  • T71271RL71；化合物 RL71RL71

    RL71 is a sselective inhibitor of SERCA2, specially binding to SERCA2 at a novel site, suppressing the Ca2+-ATPase activity of SERCA2, inducing apoptosis and downregulating Akt.

    价 格：￥电议型 号：T71271产 地：中国大陆

  • T70463FCE-27164；化合物 FCE-27164FCE-27164

    FCE-27164 is a therapeutic agent that inhibits platelet-derived growth factor beta and IL-7 binding to their receptors.

    价 格：￥电议型 号：T70463产 地：中国大陆

  • T70271PD-149163；化合物 PD-149163PD-149163

    PD-149163 is a selective, brain penetrating Neurotensin NTR1 receptor agonist. Neurotensin agonists block the pre-pulse inhibition deficits produced by a 5-HT2A and an α1 agonist. As a result, PD-149163 shows pro-cognitive, anti-psychotic and anxiolytic effects.

    价 格：￥电议型 号：T70271产 地：中国大陆

  • T7005LUlixertinib hydrochloride化合物 T7005LUlixertinib HCl|||BVD-523|||VRT752271|||BVD 523|||BVD523|||VRT 75

    Ulixertinib is an inhibitor of ERK protein kinase. Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis. Upon oral administration, BVD-523 inhibits both ERK 1 and 2, thereby preventing the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival.

    价 格：￥电议型 号：T7005L产 地：中国大陆

  • T7005Ulixertinib；优立替尼BVD-523|||VRT752271；BVD-523|||VRT752271|||优立替尼

    Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.

    价 格：￥电议型 号：T7005产 地：中国大陆

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