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T6225520S Proteasome-IN-4；化合物 20S Proteasome-IN-420S Proteasome-IN-4
20S Proteasome-IN-4 (Compound 7) is an orally active inhibitor of the 20S proteasome, selectively targeting the parasite form and demonstrating brain penetration capabilities. It exhibits a potent IC50 value of 6.3 nM against the T. b. brucei 20S proteasome, rendering it applicable for human African trypanosomiasis (HAT) research [1].
价 格：￥电议型 号：T62255产 地：中国大陆
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T61420CXCR4 antagonist 6；化合物 CXCR4 antagonist 6CXCR4 antagonist 6
CXCR4 antagonist 6 (compound 46) is a highly potent inhibitor of CXCR4 with an IC50 value of 79 nM. It effectively inhibits the cytosolic calcium flux induced by CXCL12, achieving an IC50 of 0.25 nM. Moreover, CXCR4 antagonist 6 demonstrates significant mitigation of cell migration mediated by the CXCL12/CXCR4 interaction. Notably, this compound exhibits remarkable efficacy in a mouse model of cancer metastasis [1].
价 格：￥电议型 号：T61420产 地：中国大陆
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T60420Anticancer agent 73；抗癌剂73Anticancer agent 73
Anticancer agent 73 is an anticancer agent which potently targets transactivation response(TAR) RNA-binding protein 2 (TRBP) and disrupts the TRBP-Dicer interaction. Anticancer agent 73 suppresses the growth and metastasis of HCC in vitro and in vivo by modulating expression profiles of miRNAome and proteome in HCC cells.
价 格：￥电议型 号：T60420产 地：中国大陆
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T60384VU0420373；化合物 VU0420373VU0420373
VU0420373 is a potent activator of the heme sensor system (HssRS), demonstrating an EC50 of 10.7 μM and a pEC50 of 4.97. It induces heme biosynthesis and exhibits toxicity towards fermenting S. aureus [1].
价 格：￥电议型 号：T60384产 地：中国大陆
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T5420LCycloguanil；环氯胍Cycloguanyl|||Chlorguanide triazine；Cycloguanyl|||Chlorguanide triazine|||环氯胍
Cycloguanil is an antimalarial.
价 格：￥电议型 号：T5420L产 地：中国大陆
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T5420Cycloguanil hydrochloride；环氯胍盐酸盐Chloroguanide Triazine；Chloroguanide Triazine|||环氯胍盐酸盐
Cycloguanil hydrochloride (Chloroguanide Triazine) is an active metabolite of the antimalarial compound proguanil. It acts as an inhibitor of dihydrofolate reductase (Kis: 0.3 and 1.5 nM for Plasmodium and human forms, respectively).
价 格：￥电议型 号：T5420产 地：中国大陆
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T5344SP-420；化合物SP-420SP 420；SP 420
SP-420 is a novel orally active iron chelator.
价 格：￥电议型 号：T5344产 地：中国大陆
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T44204-Hydroxytamoxifen；4-羟基他莫昔芬ICI 79280|||(Z)-4-hydroxy Tamoxifen|||trans-4-Hydroxytamoxifen；ICI 79280|
4-Hydroxytamoxifen (ICI 79280) is the active metabolite of Tamoxifen, an estrogen receptor modulator (SERM) with selective and oral potency. 4-Hydroxytamoxifen has antitumor activity and may be used in breast cancer research.
价 格：￥电议型 号：T4420产 地：中国大陆
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T4290Preladenant；瑞德南特SCH-420814；SCH-420814|||瑞德南特
Preladenant (SCH-420814) is an orally bioavailable antagonist of the adenosine A2A receptor (Ki: 1.1 nM) and has >1000-fold selectivity over all other adenosine receptors.
价 格：￥电议型 号：T4290产 地：中国大陆
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T4209TAK-659 hydrochloride；化合物TAK-659 hydrochlorideTAK-659；TAK-659
TAK-659 hydrochloride (TAK-659) is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM. It is selective against most other kinases, but potent toward both SYK and FLT3.
价 格：￥电议型 号：T4209产 地：中国大陆
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T4208Targocil；化合物TargocilTargocil
Targocil is used as a bacteriostatic inhibitor of wall teichoic acid (WTA) biosynthesis which can inhibit the growth of methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA) (MIC90s: 2 μg/ mL) for both MRSA and MSSA.
价 格：￥电议型 号：T4208产 地：中国大陆
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T4207(S,R,S)-AHPC hydrochloride；化合物Protein degrader 1 hydrochlorideVHL Ligand 1 hydrochloride|||ULM-1|||P
(S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs).
价 格：￥电议型 号：T4207产 地：中国大陆
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T4206E6446；化合物E6446E6446
E6446 inhibits Toll-like receptor (TLR)7 and 9 signaling. E6446 works in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro. When administered to mice, this compound suppress responses to challenge doses of cytidine-phosphate-guanidine (CpG)-containing DNA, which stimulates TLR9.
价 格：￥电议型 号：T4206产 地：中国大陆
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T4205AG-494；化合物AG 494Tyrphostin AG-494|||AG 494|||Tyrphostin B48；Tyrphostin AG-494|||AG 494|||Tyrphostin
AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.
价 格：￥电议型 号：T4205产 地：中国大陆
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T42046-ethyl-7-hydroxy-4-methylchromen-2-one；化合物T42046-ethyl-7-hydroxy-4-methylcoumarin；6-ethyl-7-hydroxy
6-Ethyl-7-hydroxy-4-methylchromen-2-one is a fluorescent dye.
价 格：￥电议型 号：T4204产 地：中国大陆
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T4202Delamanid德拉马尼迪拉马尼|||德拉马尼|||OPC-67683
Delamanid (OPC-67683) is an anti-tuberculosis agent derived from the nitro-dihydro-imidazooxazole class of compounds that inhibits mycolic acid synthesis of bacterial cell wall.
价 格：￥电议型 号：T4202产 地：中国大陆
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T4201Avibactam sodium；阿维巴坦钠AVE-1330A|||NXL-104；阿维巴坦|||AVE-1330A|||阿维巴坦钠|||NXL-104
Avibactam sodium (NXL-104) is a reversible β-lactamase inhibitor (IC50: 8/80/38 nM, for TEM-1/P99/KPC-2 β-lactamases).
价 格：￥电议型 号：T4201产 地：中国大陆
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T4200Sacubitril hemicalcium salt；LCZ696中间体AHU-377 (hemicalcium salt)|||AHU377 calcium salt；AHU-377 (hemic
Sacubitril hemicalcium salt (AHU377 calcium salt) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696. Sacubitril hemicalcium salt is a prodrug of LBQ657, which is an inhibitor of the zinc metallopeptidase neprilysin. Neprilysin degrades a variety of vasoactive peptides such as atrial and brain natriuretic peptide, bradykinin, adrenomedullin, and endothelin-1. Inhibition of neprilysin leads to an increased level of these
价 格：￥电议型 号：T4200产 地：中国大陆
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T40662Isepamicin；IsepamicinSch 21420；Sch 21420
Isepamicin (Sch 21420) is a potent aminoglycoside antibacterial compound with enhanced efficacy against strains harboring type I 6´-acetyltransferase. Its antibacterial spectrum encompasses Enterobacteriaceae and staphylococci, while exhibiting resistance against anaerobes, Neisseriaceae, and streptococci. Moreover, Isepamicin displays a robust concentration-dependent bactericidal effect, a prolonged post-antibiotic effect lasting several hours, and is capable of inducing adaptive resistan
价 格：￥电议型 号：T40662产 地：中国大陆
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T40420Namoline；萘莫胺Namoline
Namoline is a γ-pyrone compound that functions as a selective and reversible inhibitor of Lysine-specific demethylase 1 (LSD1) with an IC50 of 51 μM in an HRP-coupled enzymatic assay. By impairing LSD1 demethylase activity, Namoline effectively inhibits cell proliferation. Due to its characteristics, Namoline holds promise for research pertaining to androgen-dependent prostate cancer.
价 格：￥电议型 号：T40420产 地：中国大陆
