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T61025GSK-1482160
GSK-1482160 is a CNS-penetrant negative allosteric modulator of P2X7 receptor with oral activity. The P2X7 receptor is involved in the production of pro-inflammatory cytokines by central and peripheral immune cells, so GSK-1482160 has the potential to study inflammatory diseases. GSK-1482160 shows excellent in vitro potency (in functional and electrophysiological assays at recombinant and naive P2X7 receptors across multiple species including humans) and cross-target selectivity.
价 格：￥电议型 号：T61025产 地：中国大陆
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T7484LWKYMVM 2TFA(187986-17-0(free base))WKYMVM 2TFA(187986170(free base)),WKYMVM 2TFA(187986 17 0(free ba
WKYMVM 2TFA is a N-formyl peptide receptor (FPR1) agonist.
价 格：￥电议型 号：T7484L产 地：中国大陆
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T61111UCB-5307
UCB-5307 is a TNF signaling inhibitor with a K D of 9 nM. UCB-5307 can penetrate the preformed hTNF/hTNFR1 complex [1].
价 格：￥电议型 号：T61111产 地：中国大陆
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T14613BIP-135BIP 135,BIP135
BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor. With IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect[1].
价 格：￥电议型 号：T14613产 地：中国大陆
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T7611ODM-203anti-tumor immunity,ODM-203,FGFR,HUVEC,H1581,Inhibitor,cancer,Vascular endothelial growth fac
ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity
价 格：￥电议型 号：T7611产 地：中国大陆
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T9542NS3861α3β4 nAChR,inhibit,NS 3861,Inhibitor,NS3861,Heteromeric,Patch Clamp,Nicotinic acetylcholine re
NS3861 is an agonist of nicotinic acetylcholine receptors (nAChRs) and bind with high affinity to heteromeric α3β4 and α4β2 nAChRs. NS3861 displays the β-subunit preference and a complete lack of activation at α4-containing receptors. The maximal efficacy of NS3861 appeared solely dependent on the nature of the ligand-binding domain. Furthermore, a principal subunit serine to threonine substitution may explain the lack of NS3861 activation at α4-containing receptors.
价 格：￥电议型 号：T9542产 地：中国大陆
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T23145PHA 543613PHA 543613 hydrochloride
PHA 543613 is a specific agonist of α7 nAChR (Ki = 8.8 nM) and can be used in studies about the cognitive deficits of Alzheimer´s disease and schizophrenia.
价 格：￥电议型 号：T23145产 地：中国大陆
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T7616LA 779 TFA(159432-28-7 free base)A 779 TFA(159432 28 7 free base),A 779 TFA(159432287 free base)
A 779(3TFA) is a potent antagonist of angiotensin-(1-7) receptor
价 格：￥电议型 号：T7616L产 地：中国大陆
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T6S0619Pachymic acidPachymic acid,PKB,Protein kinase B,inhibit,Akt,ERK,Extracellular signal regulated kinas
Pachymic acid is a natural product, and inhibits Akt and ERK signaling pathways.
价 格：￥电议型 号：T6S0619产 地：中国大陆
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T9595LP-261NCI-H522,tubulin polymerization,tumor,SW-620,BXPC-3,H522,anti-mitotic,inhibit,LP261,MCF-7,Inhi
LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest.
价 格：￥电议型 号：T9595产 地：中国大陆
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T6104Cerdulatinib hydrochloridePRT 062070,PRT 2070,Inhibitor,malignancies,Tyk2,Cerdulatinib hydrochloride
Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively. Also inhibits 19 other tested kinases with IC50 less than 200 nM.
价 格：￥电议型 号：T6104产 地：中国大陆
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T8361Tetraethylammonium bromideTetraethylammonium bromide
Tetraethylammonium bromide can selectively block potassium channels.
价 格：￥电议型 号：T8361产 地：中国大陆
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TP1616LHsp70-derived octapeptide acetateHsp70derived octapeptide acetate,Hsp70 derived octapeptide acetate,
Hsp70-derived octapeptide acetate is a group of tetratricopeptide repeat (TPR)-containing proteins has been shown to interact with the C-terminal domain of the 70 kDa heat-shock cognate protein (hsc70). In the present study, the effect of the TPR-containing proteins, including the C-terminus of hsc70-interacting protein (CHIP), TPR1 and human glutamine-rich TPR-containing protein (hSGT), on refolding of luciferase by DnaJ and hsc70 was investigated.
价 格：￥电议型 号：TP1616L产 地：中国大陆
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T7530PD146176inhibit,tau,brain,triple,NSC-168807,PD146176,Autophagy,pathology,amyloidosis,transgenic,reti
PD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.
价 格：￥电议型 号：T7530产 地：中国大陆
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T7617LNeurotensin(8-13) 3TFA(60482-95-3(free base))Neurotensin(813) 3TFA(60482953(free base)),Neurotensin(
Neurotensin(8-13)(3TFA) is Neurotensin (NT) fragment, Neurotensin(8-13) results in a decrease in cell-surface NT1 receptors (NTR1) density.
价 格：￥电议型 号：T7617L产 地：中国大陆
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T93615-bromo-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione5 bromo 2 (2,6 dioxopiperidin 3 yl)isoindole 1
5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione is a chemical compound.
价 格：￥电议型 号：T9361产 地：中国大陆
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TP1618LPACAP-38 (31-38), human, mouse, rat acetatePACAP38 (3138), human, mouse, rat acetate,PACAP 38 (31 38
PACAP-38 (31-38), human, mouse, rat acetate is an activator of PAC1 receptor. PACAP-38 (31-38), human, mouse, rat acetate demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production and can
价 格：￥电议型 号：TP1618L产 地：中国大陆
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T6610NSC-207895XI006,MDMX,p53,LPS,Inhibitor,XI 006,MDM2,inhibit,MDM-2/p53,NSC-207895,NSC207895
NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
价 格：￥电议型 号：T6610产 地：中国大陆
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T8614[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetic acid[2(4Chlorophenyl)1,3thiazol4yl]acetic acid,[2 (4 Chl
[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetic acid is an anti-inflammatory thiazole
价 格：￥电议型 号：T8614产 地：中国大陆
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T8957LCRT0066101 dihydrochloride(956121-30-5 free base)CRT-0066101 dihydrochloride(956121-30-5 free base),
CRT0066101 dihydrochloride is an inhibitor of PKD.
价 格：￥电议型 号：T8957L产 地：中国大陆
