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T6153IcotinibIcotinib,BPI-2009,BPI-2009H
Icotinib is an orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity.
价 格:¥电议型 号:T6153产 地:美洲
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T6220Nicotinamide riboside chlorideNicotinamide riboside chloride
Nicotinamide riboside chloride, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+.
价 格:¥电议型 号:T6220产 地:美洲
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T838448-(2-azidobenzylthio) NAD+ sodium;化合物 8-(2-azidobenzylthio) NAD+ sodium8-(2-azidobenzylthio) Nicotin
8-(2-azidobenzylthio) NAD+ is a derivatized version of NAD+, a signaling molecule and enzyme cofactor, featuring an azido group (azidobenzylthio) that enables click chemistry applications.
价 格:¥电议型 号:T83844产 地:中国大陆
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T83801ε-NAADP+ sodium;化合物 ε-NAADP+ sodiumEtheno-NAADP|||β-Nicotinic Acid-1|||N6-Ethenoadenine dinucleotide
ε-NAADP+ is a fluorescent derivative of NAADP, known for inducing calcium mobilization. It effectively induces calcium release in sea urchin egg homogenates with an EC50 of 5 ?M. The compound exhibits excitation and emission maxima at 275 nm and 410 nm, respectively. Notably, its emission intensity increases three-fold when dissolved in DMSO.
价 格:¥电议型 号:T83801产 地:中国大陆
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T838006-Biotin-17-NAD+ sodium;化合物 6-Biotin-17-NAD+ sodium6-Biotin-17-Nicotinamide adenine dinucleotide|||β
6-Biotin-17-NAD+, a biotinylated derivative of the signaling molecule and enzyme cofactor NAD+, is utilized in high-throughput screening (HTS) assays to measure the activity of mitochondrial complex I, also referred to as NADH dehydrogenase.
价 格:¥电议型 号:T83800产 地:中国大陆
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T837996-alkyne NAD+ sodium;化合物 6-alkyne NAD+ sodiumβ-Nicotinamide-N6-propargyladenine dinucleotide|||6-Par
6-alkyne NAD+, a clickable variant of the signaling molecule and enzyme cofactor NAD+, facilitates the fluorescent tagging for the detection of poly(ADP-ribose) polymerase (PARP) protein substrates.
价 格:¥电议型 号:T83799产 地:中国大陆
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T837988-bromo NAD+ sodium;化合物 8-bromo NAD+ sodium8-bromo Nicotinamide adenine dinucleotide|||N(8-bromo-A)D
8-Bromo NAD+ serves as a prodrug for the cyclic ADP-ribose (cADPR) inhibitor, 8-bromo cADPR, undergoing conversion to its active form by the enzyme CD38. At a concentration of 1 mM, it effectively inhibits the rise in intracellular calcium levels and chemotaxis triggered by N-formyl-Met-Leu-Phe (fMLP) in mouse bone marrow-derived neutrophils. Furthermore, when applied at 100 ?M, this compound reduces LPS-induced nitrite production and decreases the secretion of TNF-α and IL-2 in mouse primary mi
价 格:¥电议型 号:T83798产 地:中国大陆
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T83675Thio-NAD;化合物 Thio-NADThionicotinamide NAD|||Thionicotinamide adenine dinucleotide;Thionicotinamide N
Thio-NAD, a thione-modified derivative of the signaling molecule and enzyme cofactor NAD+, can substitute for NAD+ as a cofactor in alkaline phosphatase (ALP) enzyme activity assays. It is utilized as a substrate in dual-enzyme cycling ELISA for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein, or surface glycoprotein, and live M. tuberculosis in patient sputum. Thio-NAD is characterized by its absorbance at 405 nm, distinguishing it from other cof
价 格:¥电议型 号:T83675产 地:中国大陆
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T83665α-Helical CRF (9-41) TFA;化合物 α-Helical CRF (9-41) TFAα-Helical Corticotropin-Releasing Factor (9-41)
α-Helical CRF (9-41) is a synthetic peptide antagonist that targets corticotropin-releasing factor (CRF), effectively inhibiting CRF-induced adrenocorticotropic hormone (ACTH) release both in vitro, with isolated rat anterior pituitary cells at concentrations of 0.5 to 5 ?M, and in vivo, in non-anesthetized, intact rats at doses ranging from 0.02 to 0.6 ?mol/kg. Moreover, it prevents stress-induced ACTH release at a dose of 0.6 ?mol/kg in rats and demonstrates the ability to enhance social inter
价 格:¥电议型 号:T83665产 地:中国大陆
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T83484[Tyr0] Corticotropin Releasing Factor, ovine;化合物 [Tyr0] Corticotropin Releasing Factor, ovine[Tyr0]
[Tyr^0] Corticotropin Releasing Factor, ovine, is a hypothalamic hormone sourced from sheep that prompts the secretion of adrenocorticotropic hormone (ACTH) and β-endorphin [1] [2].
价 格:¥电议型 号:T83484产 地:中国大陆
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T83178ACTH (6-24) (human);化合物 ACTH (6-24) (human)Adrenocorticotropic hormone (6-24);Adrenocorticotropic ho
Adrenocorticotropic hormone (6-24) (ACTH (6-24) (human)) is a fragment of ACTH that acts as a competitive inhibitor of steroidogenesis prompted by full-length ACTH (1-39) and the shortened ACTH (5-24), with dissociation constants (Kd) of 13.4 nM and 3.4 nM, respectively. It also impedes the production of corticosterone and the accumulation of cyclic AMP (cAMP) triggered by human parathyroid hormone (hPTH 1-34) [1] [2].
价 格:¥电议型 号:T83178产 地:中国大陆
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T82547Dirucotide;化合物 DirucotideMBP8298;MBP8298
Dirucotide (MBP8298), a synthetic 17-amino acid peptide, mirrors a segment of human myelin basic protein and has applications in research on central nervous system autoimmune disorders, including Multiple Sclerosis (MS) [1].
价 格:¥电议型 号:T82547产 地:中国大陆
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T8231ACTH (1-39) human;ACTH (1-39) 人Adrenocorticotropic Hormone (ACTH) (1-39), human|||ACTH (1-39), human
Adrenocorticotropic Hormone (ACTH) (1-39), human (ACTH (1-39), human) is an agonist of melanocortin receptor.
价 格:¥电议型 号:T8231产 地:中国大陆
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T8166Pennogenin 3-O-beta-chacotrioside化合物Pennogenin 3-O-beta-chacotrioside偏诺皂苷元-3-O-Α-L-吡喃鼠李糖-(1→4)[Α-L-吡
Pennogenin 3-O-beta-chacotrioside is an active component isolated from Paris polyphylla with anti-colorectal cancer activity. It modulates autophagy via increasing the expressions of autophagy-related proteins LC3 and Beclin-1.
价 格:¥电议型 号:T8166产 地:中国大陆
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T80694β-Corticotropin (swine);化合物 β-Corticotropin (swine)β-Corticotropin (swine)
β-Corticotropin (swine), a synthetic analog of the peptide hormone corticotropin (ACTH), induces steroid release [1] [2].
价 格:¥电议型 号:T80694产 地:中国大陆
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T80574Becotatug;化合物 BecotatugJMT-101;JMT-101
Becotatug (JMT-101) is an IgG1 antibody that targets EGFR and can be conjugated to Afatinib and Osimertinib, functioning as a synthetic antibody-drug conjugate (ADC) [1].
价 格:¥电议型 号:T80574产 地:中国大陆
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T80452Ceratotoxin-1;化合物 Ceratotoxin-1CcoTx1|||β-TRTX-cm1a;CcoTx1|||β-TRTX-cm1a
Ceratotoxin-1 (CcoTx1) is a peptide toxin that functions as an inhibitor of various voltage-gated sodium channel subtypes. It selectively inhibits Nav1.1/β1, Nav1.2/β1, Nav1.4/β1, and Nav1.5/β1 with IC50 values of 523 nM, 3 nM, 888 nM, and 323 nM, respectively. Additionally, Ceratotoxin-1 is known to inhibit Nav1.8/β1 [1].
价 格:¥电议型 号:T80452产 地:中国大陆
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T80451Ceratotoxin-2;化合物 Ceratotoxin-2CcoTx2|||β-TRTX-cm1b;CcoTx2|||β-TRTX-cm1b
Ceratotoxin-2 (CcoTx2) is a voltage-gated sodium channel inhibitor, demonstrating half maximal inhibitory concentrations (IC50) of 8 nM for Na v 1.2/β 1 and 88 nM for Na v 1.3/β 1 [1].
价 格:¥电议型 号:T80451产 地:中国大陆
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T80160ω-Hexatoxin-Hv1a;化合物 ω-Hexatoxin-Hv1aω-ACTX-Hv1|||ω-Atracotoxin-HV1;ω-ACTX-Hv1|||ω-Atracotoxin-HV1
ω-Hexatoxin-Hv1a, a neurotoxin extracted from the venom of the spider Hadronyche versuta, inhibits voltage-gated calcium channels [1] [2].
价 格:¥电议型 号:T80160产 地:中国大陆
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T79196-Aminonicotinic acid;6-氨基烟酸6-Aminonicotinic acid
6-Aminonicotinic acid is a natural product.
价 格:¥电议型 号:T7919产 地:中国大陆