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  • T76204a-Helical Corticotropin Releasing Factor (9-41)；化合物 a-Helical Corticotropin Releasing Factor (9-41)a

    α-Helical Corticotropin Releasing Factor (9-41) is a corticotropin releasing factor (CRF) antagonist that lowers plasma growth hormone (GH) levels in vivo [1] [2].

    价 格：￥电议型 号：T76204产 地：中国大陆

  • T75456-Aminonicotinamide；6-氨基烟酰胺6-Aminonicotinamide

    6-Aminonicotinamide (6-AN) is a well-established inhibitor of the NADP+-dependent enzyme.

    价 格：￥电议型 号：T7545产 地：中国大陆

  • T75309R-(+)-Cotinine；化合物 R-(+)-CotinineR-(+)-Cotinine

    R-(+)-Cotinine ((+)-Cotinine), a metabolite of Nicotine, demonstrates minimal activity across numerous pharmacological targets. However, it is capable of enhancing the acetylcholine (Ach)-evoked current in human α7 nicotinic acetylcholine receptors (nAChRs) [1].

    价 格：￥电议型 号：T75309产 地：中国大陆

  • T73664Adrenocorticotropic hormone TFA；化合物 Adrenocorticotropic hormone TFAAdrenocorticotropic hormone TFA

    Adrenocorticotropic hormone (ACTH) TFA, a polypeptide tropic hormone synthesized by the anterior pituitary gland, regulates the production of cortisol and androgens [1] [2].

    价 格：￥电议型 号：T73664产 地：中国大陆

  • T73663Adrenocorticotropic hormone；化合物 Adrenocorticotropic hormoneAdrenocorticotropic hormone

    Adrenocorticotropic hormone (ACTH), a polypeptide tropic hormone secreted by the anterior pituitary gland, regulates cortisol and androgen production [1] [2].

    价 格：￥电议型 号：T73663产 地：中国大陆

  • T72188Nicotinamide Hydrochloride；化合物 Nicotinamide HydrochlorideNiacinamide Hydrochloride|||Nicotinic acid

    Nicotinamide Hydrochloride is a form of vitamin B3 or niacin that inhibits sirtuin 2 ( SIRT2 ) activity in vitro , with an EC 50 of 2 μM. Nicotinamide Hydrochloride inhibits up to 90% melanoma cell number and increases cellular NAD + , ATP, ROS levels. Nicotinamide Hydrochloride inhibts tumor growth in vivo and improves survival of melanoma-bearing mice, which can be used for the research of skin cancers such as melanoma [1] .

    价 格：￥电议型 号：T72188产 地：中国大陆

  • T720276-Methyl-3-pyridinecarboxaldehyde6-甲氧基-3-吡啶甲醛6-Methoxynicotinaldehyde

    6-Methyl-3-pyridinecarboxaldehyde (6-Methoxynicotinaldehyde) has partial antitumor activity.

    价 格：￥电议型 号：T72027产 地：中国大陆

  • T71361CHS-828 nicotinate；化合物 CHS-828 nicotinateCHS-828 nicotinate

    CHS-828 nicotinate is a CHS-828 salt with Nicotinic acid.. CHS-828 also known as GMX-1778, is a potent and selective NAMPT inhibitor. CHS-828 inhibits cellular synthesis of NAD. CHS 828 kill tumour cells by inhibiting the nuclear factor-kappaB translocation but unlikely through down-regulation of proteasome. CHS 828 has shown promising anticancer activity in experimental tumor models and primary cultures of cancer cells from patients. CHS 828 showed a synergistic effect with melphalan in 67%,

    价 格：￥电议型 号：T71361产 地：中国大陆

  • T71106Cotosudil 2HCl；化合物 Cotosudil 2HClCotosudil 2HCl

    Cotosudil 2HCl is the salt form of Cotosudil Free Base, a Rho-associated (ROCK) kinase inhibitor.

    价 格：￥电议型 号：T71106产 地：中国大陆

  • T70625Nicotine lactate；化合物 Nicotine lactateNicotine lactate

    Nicotine is a naturally produced alkaloid in the nightshade family of plants (most predominantly in tobacco and Duboisia hopwoodii) and is widely used recreationally as a stimulant and anxiolytic. As a pharmaceutical drug, it is used for smoking cessation to relieve withdrawal symptoms. Nicotine acts as a receptor agonist at most nicotinic acetylcholine receptors (nAChRs), except at two nicotinic receptor subunits (nAChRα9 and nAChRα10) where it acts as a receptor antagonist.

    价 格：￥电议型 号：T70625产 地：中国大陆

  • T70444Edicotinib HCl；化合物 Edicotinib HClEdicotinib HCl

    Edicotinib, also known as JNJ-40346527, is a small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) with potential antineoplastic activity. FMS tyrosine kinase inhibitor JNJ-40346527 blocks the receptor-ligand interaction between FMS and its ligand CSF1, thereby preventing autophosphorylation of FMS. As a result, unphosphorylated FMS cannot activate FMS-mediated signaling pathways, thus potentially inhibiting cell proliferation in FMS-overexpressed tum

    价 格：￥电议型 号：T70444产 地：中国大陆

  • T70279Cotadutide；化合物 CotadutideCotadutide

    Cotadutide is a dual receptor agonist that modifies the activity of glucagon and glucagon-like peptide-1 (GLP-1).

    价 格：￥电议型 号：T70279产 地：中国大陆

  • T70122Acotiamide Methyl Ether；化合物 Acotiamide Methyl EtherAcotiamide Methyl Ether

    Acotiamide Methyl Ether is a metabolite of Acotiamide -- an acetylcholinesterase inhibitor which has been shown to stimulate gastric motility and improve gastric motility dysfunction in rats. Acotiamide Hydrochloride has also been shown to improve meal-related symptoms of functional dyspepsia.

    价 格：￥电议型 号：T70122产 地：中国大陆

  • T6S1294Nicotiflorin；山奈酚-3-O-芸香糖苷Nictoflorin|||Kaempferol-3-O-Rutinoside|||Nicotifloroside；Nictoflorin|||Kae

    1. Nicotiflorin (Kaempferol-3-O-Rutinoside) has potential therapeutic effects on cerebral ischemic illness. 2. Nicotiflorin has protective effects on reducing memory dysfunction, energy metabolism failure and oxidative stress in multi-infarct dementia model rats.

    价 格：￥电议型 号：T6S1294产 地：中国大陆

  • T69395Nicotinamide-d4；化合物 Nicotinamide-d4Nicotinamide-d4

    Nicotinamide-d4 is intended for use as an internal standard for the quantification of nicotinamide by GC- or LC-MS. Nicotinamide is an amide form of niacin, which is also known as vitamin B3, that can be biosynthesized in vivo or obtained through the diet. It is a precursor in the synthesis of the metabolic cofactor NAD+ and an inhibitor of sirtuin 1 (SIRT1; IC50 = <50 ?M). Nicotinamide (10 ?M) increases the activity of serine palmitoyltransferase (SPT) and the biosynthesis of ceramide, glucosyl

    价 格：￥电议型 号：T69395产 地：中国大陆

  • T69134Metanicotine；化合物 MetanicotineMetanicotine

    Metanicotine is a selective nicotinic agonist with antinociceptive properties.

    价 格：￥电议型 号：T69134产 地：中国大陆

  • T69073COTC；化合物 COTCCOTC

    COTC is a bacterial metabolite that has anticancer activity and inhibits glyoxalase in the presence of glutathione (GSH) and the proliferation of HeLa cells, as well as reduces tumor growth and improves survival in an Ehrlich murine spontaneous adenocarcinoma model.

    价 格：￥电议型 号：T69073产 地：中国大陆

  • T68942Caricotamide；化合物 CaricotamideCaricotamide

    Caricotamide is a synthetic co-substrate that activates the human endogenous enzyme NRH:quinone oxidoreductase 2 (NQO2) with potential chemoadjuvant activity. When caricotamide is administered simultaneously with the prodrug tretazicar, NQO2 converts tretazicar to the bifunctional alkylating agent dinitrobenzamide, which is capable of forming a high degree of DNA interstrand cross-links, resulting in the inhibition of DNA replication and the induction of apoptosis. NQO2 has been found to be over

    价 格：￥电议型 号：T68942产 地：中国大陆

  • T68819Icotidine hydrochloride；化合物 Icotidine hydrochlorideIcotidine hydrochloride

    Icotidine hydrochloride is an antagonist of histamine at both H1 and H2 receptors.

    价 格：￥电议型 号：T68819产 地：中国大陆

  • T68818Icotidine；化合物 IcotidineIcotidine

    Icotidine is an antagonist of histamine at both H1 and H2 receptors.

    价 格：￥电议型 号：T68818产 地：中国大陆

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