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  • T8224VU0119498；化合物VU0119498VU0119498

    VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent.

    价 格：￥电议型 号：T8224产 地：中国大陆

  • T82224HDAC6-IN-25；化合物 HDAC6-IN-25HDAC6-IN-25

    HDAC6-IN-25 (compound 8) is a potent and selective HDAC6 inhibitor, exhibiting an IC50 value of 0.6 nM [1].

    价 格：￥电议型 号：T82224产 地：中国大陆

  • T81224SALMF amide 2；化合物 SALMF amide 2SALMF amide 2

    SALMFamide 2, a neuropeptide S2 derived from the starfish Asterias rubens, plays a regulatory role in the eversion of the cardiac stomach in starfish [1].

    价 格：￥电议型 号：T81224产 地：中国大陆

  • T80824WAY-322454；化合物 WAY-322454WAY-322454

    WAY-322454 is an active molecule.

    价 格：￥电议型 号：T80824产 地：中国大陆

  • T80224Bid BH3 (80-99)；化合物 Bid BH3 (80-99)Bid BH3 (80-99)

    Bid BH3 (80-99) is a biologically active peptide known as a pro-apoptotic member of the ´BH3-only´ (BOPS) subset within the BCL-2 protein family, pivotal in apoptosis regulation. It notably interacts with Bcl-2, Bax, and Bak, initiating their activation or inactivation, thus inducing cell death. Additionally, Bid translocates from the cytosol to the mitochondrial membrane as part of its functional mechanism. The presence of Pyroglutamyl (pGlu) peptides, which can spontaneously arise

    价 格：￥电议型 号：T80224产 地：中国大陆

  • T79224Ara-SH；化合物 Ara-SHAra-SH

    Ara-SH, a derivative of Cytarabine with a mercaptopropionic acid substitution, serves as the initiator for the self-assembly of a smart, co-loaded Cytarabine and Venetoclax nanoparticle (AV-NP), demonstrating notable synergistic antileukemia effects both in vitro and in vivo [1].

    价 格：￥电议型 号：T79224产 地：中国大陆

  • T78224Histatin-3；化合物 Histatin-3Histatin-3

    Histatin-3, a 32-amino-acid peptide, exhibits potent antimicrobial activities and serves as a substrate for proprotein convertase 1 (PC1), where it is primarily cleaved at a site carboxy-terminal to Arg25 (HRGYR↓SN). Additionally, it acts as a moderately potent, reversible, and competitive inhibitor of furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an inhibition constant (Ki) estimated at 1.98 μM [1].

    价 格：￥电议型 号：T78224产 地：中国大陆

  • T77619WAY-322243；化合物WAY-322243WAY-322243

    WAY-322243 has antibacterial and anti-inflammatory activity and has an inhibitory effect on CLK-1, which can be used to study Alzheimer´s disease.

    价 格：￥电议型 号：T77619产 地：中国大陆

  • T77437Telisotuzumab；特立妥珠单抗ABT-700|||Mab-224G11；ABT-700|||Mab-224G11

    Telisotuzumab(ABT-700) is a humanized recombinant antibody targeting the therapeutic hepatocyte growth factor receptor (MET) with high affinity for c-Met.Telisotuzumab has inhibitory effects on c-Met signaling and antitumor activity.

    价 格：￥电议型 号：T77437产 地：中国大陆

  • T76883Talacotuzumab；塔妥珠单抗CSL 362|||JNJ 56022473；CSL 362|||JNJ 56022473

    Talacotuzumab (JNJ 56022473) is an IgG1 fully humanized CD123 neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has a high affinity for CD123, CD32b/c, CD16-158F and CD16-158V, with KD of 0.43 nM, 188 nM, 46 nM and 16.8 nM, respectively. Talacotuzumab inhibits IL-3 signaling in target cells by inhibiting IL-3 binding to CD123. Talacotuzumab induces mutations in the Fc region to increase affinity for CD16 (FCγriiia), thereby enhancing antibody-dependent cell-media

    价 格：￥电议型 号：T76883产 地：中国大陆

  • T76830Teneliximab；化合物TeneliximabChi220|||Anti-Human CD40 Recombinant Antibody|||BMS 224819；Chi220|||Anti-H

    Teneliximab (Chi220) is a chimeric monoclonal antibody and a tumor necrosis factor receptor superfamily member 5 (CD40) inhibitor that blocks CD40-CD40L interactions.Teneliximab exerts partial agonist activity through CD40 and peripheral B-cell depletion, and may be used to study organ transplant rejection and rheumatoid arthritis.

    价 格：￥电议型 号：T76830产 地：中国大陆

  • T76224NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal)；化合物 NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal)NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal)

    Compound 40, NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal), a macrocyclic analogue of Ape13, acts as a potent APJ agonist with a Ki of 5.7 nM. It demonstrates favorable Gα12-biased signaling and possesses an enhanced in vivo half-life [1].

    价 格：￥电议型 号：T76224产 地：中国大陆

  • T75140CPD-1224；化合物 CPD-1224CPD-1224

    CPD-1224, an orally active derivative that binds cereblon ligands to ALK inhibitors, specifically targets and degrades EML4-ALK oncogenic fusions, including ALK and its mutants L1196M/G1202R.

    价 格：￥电议型 号：T75140产 地：中国大陆

  • T74224UNC6349 (Ket2)；化合物 UNC6349 (Ket2)UNC6349 (Ket2)

    UNC6349 (Ket2), a ligand containing diethyllysine (Ket2), effectively binds to wild-type CBX5 with a dissociation constant (K D) of 3.2 μM [1].

    价 格：￥电议型 号：T74224产 地：中国大陆

  • T73224AMPK-IN-1；化合物 AMPK-IN-1AMPK-IN-1

    AMPK-IN-1 is an activator of the AMP-activated protein kinase (AMPK) enzyme, specifically targeting the α2β2γ1 isoform with an EC50 of 551 nM. It induces phosphorylation of eEF2 independent of the mTORC1 pathway.

    价 格：￥电议型 号：T73224产 地：中国大陆

  • T72249BMS-823778 hydrochloride；化合物 BMS-823778 hydrochlorideBMS-823778 hydrochloride

    BMS-823778 hydrochloride is a potent, selective, and orally active inhibitor of 11β-HSD1 (11β-Hydroxysteroid Dehydrogenase Type 1), demonstrating an IC50 (half maximal inhibitory concentration) of 2.3 nM against the human form of the enzyme.

    价 格：￥电议型 号：T72249产 地：中国大陆

  • T72248MRS2768 tetrasodium salt；化合物 MRS2768 tetrasodium saltMRS2768 tetrasodium salt

    MRS2768 tetrasodium salt, a moderately potent and selective agonist of the P2Y2 receptor, exhibits a protective effect against ischemic damage in cardiomyocytes both in vivo and in vitro.

    价 格：￥电议型 号：T72248产 地：中国大陆

  • T72247Ladostigil hydrochloride；化合物 Ladostigil hydrochlorideTV-3326 hydrochloride；TV-3326 hydrochloride

    Ladostigil hydrochloride (TV-3326), an orally active compound, acts as a dual inhibitor targeting both cholinesterase and brain-selective monoamine oxidase (MAO), demonstrating inhibition constants (IC50s) of 31.8 μM for acetylcholinesterase (AChE) and 37.1 μM for MAO-B. This compound exhibits neuroprotective, antioxidant, and anti-inflammatory properties, making it useful for research into depression and Alzheimer´s disease.

    价 格：￥电议型 号：T72247产 地：中国大陆

  • T72246Bicuculline methobromide；化合物 Bicuculline methobromide(+)-Bicuculline methobromide|||d-Bicuculline me

    Bicuculline methobromide, a selective GABAA Receptor antagonist with an IC50 value of 3 μM, induces tonic-clonic convulsions in mammals and blocks Ca2+ activated potassium channels. It is applicable in researching epilepsy and related psychiatric disorders.

    价 格：￥电议型 号：T72246产 地：中国大陆

  • T72245Fomepizole hydrochloride；化合物 Fomepizole hydrochloride4-Methylpyrazole hydrochloride；4-Methylpyrazole

    Fomepizole hydrochloride (4-Methylpyrazole), a potent, orally active inhibitor of cytochrome P450 (CYP2E1) and a competitive inhibitor of alcohol dehydrogenase, prevents the conversion of methanol and ethylene glycol into toxic metabolites. It has potential as an antidote for poisoning by ethylene glycol or methanol.

    价 格：￥电议型 号：T72245产 地：中国大陆

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