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T69525MIF degrader MD13；化合物 MIF degrader MD13MIF degrader MD13
MIF degrader MD13 is involved in protein-protein interactions that play key roles in inflammation and cancer. Current strategies to develop small molecule modulators of MIF functions are mainly restricted to the MIF tautomerase active siteMIF degrader MD13. MD13 also exhibits antiproliferative effect in a 3D tumor spheroid model. In conclusion, we describe the first MIF-directed PROTAC (MD13) as a research tool, which also demonstrates the potential of PROTACs in cancer therapy.
价 格：￥电议型 号：T69525产 地：中国大陆
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T64284PROTAC CDK12/13 Degrader-1；化合物 PROTAC CDK12/13 Degrader-1PROTAC CDK12/13 Degrader-1
PROTAC CDK12/13 Degrader-1 (7f) is a potent and selective dual degrader of the cell cycle protein-dependent kinases CDK12 (DC50: 2.2 nM) and CDK13 (DC50: 2.1 nM). Breast cancer.
价 格：￥电议型 号：T64284产 地：中国大陆
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T64161XIAP degrader-1；化合物 XIAP degrader-1XIAP degrader-1
XIAP degrader-1 is a small primary amine molecule that promotes the degradation of X-linked apoptosis inhibitory protein (XIAP).
价 格：￥电议型 号：T64161产 地：中国大陆
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T63922ERα degrader 5；化合物 ERα degrader 5ERα degrader 5
ERα degrader 5 is an orally active, selective estrogen receptor (ER) reducer that acts on ERα (EC50: 1.1 nM). ERα degrader 5 shows anti-tumour effects in vivo.
价 格：￥电议型 号：T63922产 地：中国大陆
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T63675ER degrader 1；化合物 ER degrader 1ER degrader 1
ER degrader 1 is a potent degrader of the estrogen receptor (ER). The estrogen signaling system plays an important role in the regulation of cell growth, differentiation and apoptosis, and ER degrader 1 has shown potential for cancer diseases.
价 格：￥电议型 号：T63675产 地：中国大陆
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T60416CRM1 degrader 1；化合物 CRM1 degrader 1CRM1 degrader 1
CRM1 degrader 1 (1l) is a low-toxic CRM1 degrader that induces apoptosis in gastric carcinoma and selectively inhibits the proliferation of gastric cancer[1].
价 格：￥电议型 号：T60416产 地：中国大陆
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T5439BRD4 degrader AT1；化合物BRD4 degrader AT1BRD4 degrader AT1
BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.
价 格：￥电议型 号：T5439产 地：中国大陆
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T5438PROTAC CDK9 Degrader-1；化合物PROTAC CDK9 Degrader-1PROTAC CDK9 Degrader-1
PROTAC CDK9 Degrader-1 is a selective CDK9 degrader.
价 格：￥电议型 号：T5438产 地：中国大陆
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T4207(S,R,S)-AHPC hydrochloride；化合物Protein degrader 1 hydrochlorideVHL Ligand 1 hydrochloride|||ULM-1|||P
(S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs).
价 格：￥电议型 号：T4207产 地：中国大陆
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T40334PROTAC IRAK3 degrade-1；PROTAC IRAK3 degrade-1PROTAC IRAK3 degrade-1；PROTAC IRAK3 degrade-1
PROTAC IRAK3 degrade-1 is a potent and selective degrader of IRAK3 ( IC 50 = 5 nM).
价 格：￥电议型 号：T40334产 地：中国大陆
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T40250SHP2 protein degrader-1；SHP2 protein degrader-1SHP2 protein degrader-1；SHP2 protein degrader-1
SHP2 protein degrader-1 is a highly efficient allosteric inhibitor targeting SHP2. It effectively induces degradation of SHP2 protein, resulting in cell apoptosis. This compound shows promising potential for studying diseases associated with SHP2.
价 格：￥电议型 号：T40250产 地：中国大陆
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T40143PROTAC CBP/P300 Degrader-1；PROTAC CBP/P300 Degrader-1PROTAC CBP/P300 Degrader-1；PROTAC CBP/P300 Degr
PROTAC CBP/P300 Degrader-1 is an effective compound that degrades CBP/P300 in a potent manner. It significantly reduces cell viability in various cancer cell lines.
价 格：￥电议型 号：T40143产 地：中国大陆
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T40112PROTAC PD-1/PD-L1 degrader-1；PROTAC PD-1/PD-L1 degrader-1PROTAC PD-1/PD-L1 degrader-1；PROTAC PD-1/PD
PROTAC PD-1/PD-L1 degrader-1, a Cereblon E3 ligand-based compound, is a PD-1/PD-L1 PROTAC that effectively inhibits the interaction between PD-1 and PD-L1 with an IC50 value of 39.2 nM. It successfully restores the suppressed immune response in a co-culture model consisting of Hep3B/OS-8/hPD-L1 cells and CD3 T cells. Additionally, this compound moderately decreases PD-L1 protein levels through a lysosome-dependent mechanism.
价 格：￥电议型 号：T40112产 地：中国大陆
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T40075PROTAC BRD4 Degrader-13；PROTAC BRD4 Degrader-13PROTAC BRD4 Degrader-13；PROTAC BRD4 Degrader-13
PROTAC BRD4 Degrader-13 (compound 9d) is a bioactive compound that functions as a proteolysis targeting chimera (PROTAC), linking ligands for von Hippel-Lindau and BRD4 proteins. In the context of PC3 prostate cancer cells, this compound effectively degrades the BRD4 protein through conjugation with STEAP1 and CLL1 antibodies. The degradation of BRD4 protein is achieved with remarkable potency, exhibiting a DC 50 of 0.025 nM and 6.0 nM when combined with STEAP1 and CLL1 antibodies, respectively.
价 格：￥电议型 号：T40075产 地：中国大陆
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T40074PROTAC BRD4 Degrader-15；PROTAC BRD4 Degrader-15PROTAC BRD4 Degrader-15；PROTAC BRD4 Degrader-15
PROTAC BRD4 Degrader-15 is a chemical compound consisting of a PROteolysis TArgeting Chimera (PROTAC) linked to ligands specific to von Hippel-Lindau and BRD4. It exhibits an IC50 of 7.2 nM for BRD4 BD1 and 8.1 nM for BRD4 BD2. Additionally, PROTAC BRD4 Degrader-15 demonstrates potent degradation activity against the BRD4 protein in PC3 prostate cancer cells.
价 格：￥电议型 号：T40074产 地：中国大陆
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T40073PROTAC BRD4 Degrader-10；PROTAC BRD4 Degrader-10PROTAC BRD4 Degrader-10；PROTAC BRD4 Degrader-10
PROTAC BRD4 Degrader-10, also known as compound 8b, is a dual ligand-based PROTAC that combines ligands for von Hippel-Lindau and BRD4. To degrade the BRD4 protein in PC3 prostate cancer cells, PROTAC BRD4 Degrader-10 can be conjugated with STEAP1 and CLL1 antibodies, with respective DC 50 values of 1.3 nM and 18 nM.
价 格：￥电议型 号：T40073产 地：中国大陆
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T40072PROTAC BRD4 Degrader-9；PROTAC BRD4 Degrader-9PROTAC BRD4 Degrader-9；PROTAC BRD4 Degrader-9
PROTAC BRD4 Degrader-9 (compound 8a) is a novel chemical compound consisting of ligands for von Hippel-Lindau and BRD4, connected by a PROTAC moiety. This compound can effectively degrade the BRD4 protein in PC3 prostate cancer cells. When conjugated with STEAP1 and CLL1 antibodies, PROTAC BRD4 Degrader-9 exhibits potent activity, with respective DC50 values of 0.86 nM and 7.6 nM.
价 格：￥电议型 号：T40072产 地：中国大陆
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T39996PROTAC CDK9 degrader-4；PROTAC CDK9 degrader-4PROTAC CDK9 degrader-4；PROTAC CDK9 degrader-4
PROTAC CDK9 degrader-4 is a potent and efficacious chemical compound designed specifically to degrade CDK9, a protein involved in transcription regulation. This compound effectively targets and reduces the levels of CDK9, thereby modulating transcriptional activity.
价 格：￥电议型 号：T39996产 地：中国大陆
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T39920PROTAC IRAK4 degrader-3；PROTAC IRAK4 degrader-3PROTAC IRAK4 degrader-3；PROTAC IRAK4 degrader-3
PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau.
价 格：￥电议型 号：T39920产 地：中国大陆
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T39903PROTAC IRAK4 degrader-6；PROTAC IRAK4 degrader-6PROTAC IRAK4 degrader-6；PROTAC IRAK4 degrader-6
PROTAC IRAK4 degrader-6 is a potent Cereblon-based compound designed to degrade interleukin-1 receptor-associated kinase 4 (IRAK4).
价 格：￥电议型 号：T39903产 地：中国大陆
