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T39902PROTAC IRAK4 degrader-5；PROTAC IRAK4 degrader-5PROTAC IRAK4 degrader-5；PROTAC IRAK4 degrader-5
PROTAC IRAK4 degrader-5 is a Cereblon-based IRAK4 degrader.
价 格：￥电议型 号：T39902产 地：中国大陆
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T39901PROTAC IRAK4 degrader-4；PROTAC IRAK4 degrader-4PROTAC IRAK4 degrader-4；PROTAC IRAK4 degrader-4
PROTAC IRAK4 degrader-4 (US20190192668A1, compound I-127) is a Cereblon-based PROTAC specifically designed to target and degrade interleukin-1 receptor-associated kinase 4 (IRAK4).
价 格：￥电议型 号：T39901产 地：中国大陆
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T39837PROTAC ERRα Degrader-3；PROTAC ERRα Degrader-3PROTAC ERRα Degrader-3
PROTAC ERRα Degrader-3 is a highly effective and selective von Hippel-Lindau-based ligand that efficiently degrades the ERRα protein. At a concentration of 30 nM, this compound exhibits a remarkable degradation capability, reducing the ERRα protein levels by >80%. Importantly, PROTAC ERRα Degrader-3 shows no activity against the ERRβ and ERRγ proteins.
价 格：￥电议型 号：T39837产 地：中国大陆
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T39727ERα degrader-2；ERα降解剂2ERα degrader-2
ERα degrader-2 is a selective and potent estrogen receptor (SERD) degrader with anticancer activity, inhibits ERα, and has an EC50 value for estrogen receptor degradation of 0.3 nM.ERα degrader-2 can be used for the prevention and treatment of HER-positive breast cancer.
价 格：￥电议型 号：T39727产 地：中国大陆
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T39685PCSK9 degrader 1；PCSK9 degrader 1PCSK9 degrader 1
PCSK9 degrader 1 is a selective proprotein convertase substilisin-like/kexin type 9 (PCSK9) degrader. PCSK9 degrader 1 does not affect PCSK9 function.
价 格：￥电议型 号：T39685产 地：中国大陆
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T39374PROTAC BET Degrader-10；PROTAC BET Degrader-10PROTAC BET Degrader-10
PROTAC BET Degrader-10 (WO2017007612A1, example 37) is a highly efficient and selective small molecule compound designed to degrade BET protein BRD4. PROTAC BET Degrader-10 functions by utilizing specific ligands that connect Cereblon and BRD4, with a DC 50 value of 49 nM.
价 格：￥电议型 号：T39374产 地：中国大陆
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T37329PROTAC IDO1 Degrader-1；PROTAC IDO1 Degrader-1PROTAC IDO1 Degrader-1；PROTAC IDO1 Degrader-1
PROTAC IDO1 Degrader-1, a pioneering compound, efficiently targets indoleamine 2,3-dioxygenase 1 (IDO1) for ubiquitination and degradation by recruiting IDO1 to the CRBN E3 ligase, thereby facilitating its entry into the ubiquitin-proteasome system (UPS) with a DC50 of 2.84 μM. This compound also moderately enhances the tumor-killing efficacy of HER2 CAR-T cells[1].
价 格：￥电议型 号：T37329产 地：中国大陆
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T36628PROTAC BRD4 Degrader-8；PROTAC BRD4 Degrader-8PROTAC BRD4 Degrader-8；PROTAC BRD4 Degrader-8
PROTAC BRD4 Degrader-8 is a potent BRD4 inhibitor, with IC50s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells[1].
价 格：￥电议型 号：T36628产 地：中国大陆
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T36256LC-2；化合物LC-2LC 2|||PROTAC KRASG12C Degrader-LC-2|||LC2；LC 2|||PROTAC KRASG12C Degrader-LC-2|||LC2
LC-2 (PROTAC KRASG12C Degrader-LC-2) is a novel von Hippel-Lindau-based PROTAC degrader of endogenous KRAS G12C with a DC50 between 0.25 and 0.76 μM.LC-2 is a PROTAC that covalently binds KRAS G12C with MRTX849 and recruits the E3 ligase, VH, to induce a rapid and sustained degradation of KRAS G12C. LC-2 inhibits MAPK signaling in pure and heterozygous KRAS G12C cell lines.
价 格：￥电议型 号：T36256产 地：中国大陆
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T36243PROTAC RIPK degrader-6；PROTAC RIPK degrader-6PROTAC RIPK degrader-6
PROTAC RIPK degrader-6 (example 1) is a PROTAC designed for the targeted degradation of RIP Kinase, featuring a RIP2 kinase inhibitor connected through a linker to a cereblon binder[1].
价 格：￥电议型 号：T36243产 地：中国大陆
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T36242PROTAC BRD4 Degrader-5PROTAC BRD4 Degrader-5PROTAC BRD4 Degrader-5
PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1].
价 格：￥电议型 号：T36242产 地：中国大陆
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T36108YW3-56 (hydrochloride) (technical grade)；YW3-56 (hydrochloride) (technical grade)YW3-56 (hydrochlori
YW3-56 is an inhibitor of protein arginine deiminase 2 (PAD2) and PAD4 (IC50s = 0.5-1 and 1-5 μM, respectively).1It inhibits the growth of U2OS osteosarcoma cells (IC50= ~2.5 μM) in a p53-dependent mannerviainduction of SESN2 and subsequent inhibition of mTORC1. YW3-56 (10 mg/kg) reduces tumor growth in an S-180 murine sarcoma tumor model. It also inhibits tumor growth in the 1883 MDA-MB-231 breast cancer bone metastasis mouse xenograft model.2
价 格：￥电议型 号：T36108产 地：中国大陆
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T18651(rel)-PROTAC ERRα Degrader-1；化合物 T18651(rel)-PROTAC ERRα Degrader-1
(rel)-PROTAC ERRα Degrader-1 is a relative configuration of PROTAC ERRα Degrader-1, which is an estrogen-related receptor alpha (ERRa) degrader. PROTAC ERRα Degrader-1 consists of an MDM2 ligand binding moiety, a linker and an ERRa binding moiety [1].
价 格：￥电议型 号：T18651产 地：中国大陆
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T18636PROTAC ERα Degrader-1；化合物 T18636PROTAC ERα Degrader-1
PROTAC ERα Degrader-1 is a chemical compound. It consists of a ubiquitin E3 ligase binding group, a linker, and a protein binding group. This compound serves as a degrader of estrogen receptor-alpha (ERα).
价 格：￥电议型 号：T18636产 地：中国大陆
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T18635PROTAC RAR Degrader-1；化合物 T18635PROTAC RAR Degrader-1
PROTAC RAR Degrader-1, an RAR degrader, consists of a cIAP1 ligand binding group, a linker, and an RAR ligand binding group. It achieves maximal RAR degradation at a concentration of 30 μM in HT1080 cells. Degradation inducers that utilize cIAP1 are known as specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].
价 格：￥电议型 号：T18635产 地：中国大陆
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T18634PROTAC MDM2 Degrader-4；化合物 T18634PROTAC MDM2 Degrader-4
PROTAC MDM2 Degrader-4 is a compound designed using PROTAC technology to degrade MDM2. It combines a powerful MDM2 inhibitor, a linker, and the MDM2 ligand for E3 ubiquitin ligase[1].
价 格：￥电议型 号：T18634产 地：中国大陆
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T18633PROTAC MDM2 Degrader-3；化合物 T18633PROTAC MDM2 Degrader-3
PROTAC MDM2 Degrader-3 is a compound that leverages PROTAC technology to degrade MDM2. It consists of a highly effective MDM2 inhibitor, a linker, and the MDM2 ligand for E3 ubiquitin ligase[1].
价 格：￥电议型 号：T18633产 地：中国大陆
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T18632PROTAC MDM2 Degrader-2；化合物 T18632PROTAC MDM2 Degrader-2
PROTAC MDM2 Degrader-2 is a compound designed utilizing PROTAC technology, functioning as a MDM2 degrader. Comprised of a highly potent inhibitor targeting MDM2, a linker, and the MDM2 ligand for E3 ubiquitin ligase, this compound facilitates the degradation of MDM2[1].
价 格：￥电议型 号：T18632产 地：中国大陆
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T18631PROTAC MDM2 Degrader-1；化合物 T18631PROTAC MDM2 Degrader-1
PROTAC MDM2 Degrader-1 is a chemical compound that utilizes PROTAC technology to degrade MDM2. This compound is comprised of a highly effective MDM2 inhibitor, a linker, and the MDM2 ligand for E3 ubiquitin ligase[1].
价 格：￥电议型 号：T18631产 地：中国大陆
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T18610PROTAC FKBP Degrader-3；化合物 T18610PROTAC FKBP Degrader-3
PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an VHL binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrader[1].
价 格：￥电议型 号：T18610产 地：中国大陆
