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  • T79139GBD-9；化合物 GBD-9GBD-9

    GBD-9, a dual-mechanism degrader, effectively promotes the degradation of BTK and GSPT1 through recruitment of E3 ligase cereblon (CRBN). As a PROTAC molecule, GBD-9 induces BTK degradation, while also acting as a molecular glue for GSPT1 degradation, demonstrating potent inhibition of cancer cell growth [1].

    价 格：￥电议型 号：T79139产 地：中国大陆

  • T78780Anticancer agent 139；化合物 Anticancer agent 139Anticancer agent 139

    Compound 6h (Anticancer Agent 139) exhibits potent anticancer activity, engaging in a π-cationic interaction with Lys352 of Tubulin and demonstrating high efficacy against SNB-19, OVCAR-8, and NCI-H460 with PGIs of 86.61, 85.26, and 75.99, respectively. Moreover, it shows moderate activity against a range of other cancer cell lines — HOP-62, SNB-75, ACHN, NCI/ADR-RES, 786-O, A549/ATCC, HCT-116, and MDA-MB-231 — with PGIs between 51.88 and 67.55 [1].

    价 格：￥电议型 号：T78780产 地：中国大陆

  • T78563[Leu13]-Motilin；化合物 [Leu13]-MotilinKW-5139；KW-5139

    [Leu13]-Motilin (KW-5139) is an analogue of the gastrointestinal hormone motilin that induces concentration-dependent contractions in rabbit gastrointestinal tissues, including the gastric antrum, duodenum, jejunum, ileum, and descending colon in vitro [1].

    价 格：￥电议型 号：T78563产 地：中国大陆

  • T78139Dimethylamiloride；化合物 DimethylamilorideDimethylamiloride

    Dimethylamiloride is a specific inhibitor of antiporters [1].

    价 格：￥电议型 号：T78139产 地：中国大陆

  • T77785WAY-301398；化合物 WAY-3013986-methoxynaphthalene；6-methoxynaphthalene

    WAY-301398 (6-methoxynaphthalene) can bind to protein kinase C (PKC).

    价 格：￥电议型 号：T77785产 地：中国大陆

  • T77139Pavurutamab；化合物 PavurutamabPavurutamab

    Pavurutamab (AMG-701) is a bispecific T-cell engager that targets CD3 and B-cell maturation antigens (BCMA), based on the extended half-life derived from Pacanalotamab. Its Fc region is engineered for improved pharmacokinetics, offering potential in immune regulation and the treatment of multiple myeloma (MM) [1] [2] [3] [4].

    价 格：￥电议型 号：T77139产 地：中国大陆

  • T76139Cholesterol esterase；化合物 Cholesterol esteraseCholesterol esterase

    Cholesterol esterase, also known as bile salt-stimulated lipase and carboxyl ester lipase, is an enzyme responsible for hydrolyzing cholesterol ester into cholesterol and free fatty acid within the intestinal lumen. This enzyme, synthesized and stored in zymogen granules within acinar cells, plays a crucial role in accelerating cholesterol absorption [1] [2].

    价 格：￥电议型 号：T76139产 地：中国大陆

  • T75139TMX1；化合物 TMX1TMX1

    TMX1 is a molecular glue degrader that covalently targets BRD4. It selectively recruits DCAF16 to the BRD4 BD2 domain, leading to the degradation of BRD4 [1].

    价 格：￥电议型 号：T75139产 地：中国大陆

  • T7493AG-13958；化合物AG-13958AG-013958；AG-013958|||N-[2-氟-5-[[3-[(1E)-2-(2-吡啶基)乙烯基]-1H-吲唑-6-基]氨基]苯基]-1,3-二甲基-

    AG-13958 (AG-013958) (AG-013958), a potent VEGFR tyrosine kinase inhibitor, for the treatment of age-related macular degeneration.

    价 格：￥电议型 号：T7493产 地：中国大陆

  • T74776Antibacterial agent 139；化合物 Antibacterial agent 139Antibacterial agent 139

    Antibacterial agent 139 exhibits antibacterial activity specifically targeting Gram-positive bacteria, including resistant strains such as MRSA (anti-MRSA), VISA (anti-VISA), and LRSE (anti-LRSE). It operates by depolarizing the bacterial cell membrane [1].

    价 格：￥电议型 号：T74776产 地：中国大陆

  • T74139MPEG-2000-DSPE；化合物 MPEG-2000-DSPEMPEG-2000-DSPE

    MPEG-2000-DSPE is a phospholipid PEG conjugate, has both hydrophilicity and hydrophobility. MPEG-2000-DSPE is used in the synthesis of liposomes, increases the hydrophilicity on the surface of liposomes, consequently increasing the longevity of liposomes in the blood circulation for the study of anticancer and antimalarial agents[1][2].

    价 格：￥电议型 号：T74139产 地：中国大陆

  • T72954Fazamorexant；化合物 FazamorexantYZJ-1139；YZJ-1139

    Fazamorexant (YZJ-1139) is a powerful orexin receptor antagonist effective for insomnia research.

    价 格：￥电议型 号：T72954产 地：中国大陆

  • T72543BOLD-100 free base；化合物 BOLD-100 free baseNKP-1339 free base ; IT-139 free base ; KP-1339 free base

    BOLD-100 free base (NKP-1339; IT-139), a ruthenium-based anticancer agent, inhibits stress-induced GRP78 upregulation, thus disrupting endoplasmic reticulum (ER) homeostasis. This action induces ER stress and unfolded protein response (UPR), interfering with the intricate relationship between ER-stress response, lysosome dynamics, and autophagy execution.

    价 格：￥电议型 号：T72543产 地：中国大陆

  • T71399Plogosertib；化合物 PlogosertibCYC140；CYC140

    Plogosertib (CYC140) is an orally active, selective, potent, and ATP-competitive PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib exhibits antiproliferative and anticancer activity and can be used for the study of solid and hematologic tumors.and hematologic tumors.

    价 格：￥电议型 号：T71399产 地：中国大陆

  • T71398RO5126946；化合物 RO5126946RO5126946

    RO5126946 is a Novel α7 nicotinic acetylcholine receptor-positive allosteric modulator. RO5126946 allosterically modulates α7nAChR activity. RO5126946 increased acetylcholine-evoked peak current and delayed current decay but did not affect the recovery of α7nAChRs from desensitization. In addition, RO5126946´s effects were absent when nicotine-evoked currents were completely blocked by coapplication of the α7nAChR-selective antagonist methyl-lycaconitine.

    价 格：￥电议型 号：T71398产 地：中国大陆

  • T71397Setileuton tosylate；化合物 Setileuton tosylateSetileuton tosylate

    Setileuton, also known as MK0633, is a potent and selective 5-lipoxygenase inhibitor which is under investigation for the treatment of asthma and atherosclerosis.

    价 格：￥电议型 号：T71397产 地：中国大陆

  • T71396FCE-24379；化合物 FCE-24379FCE-24379

    FCE-24379 is a selective antagonist of vascular serotonin receptors that has been shown to lowers blood pressure in hypertensive rats.

    价 格：￥电议型 号：T71396产 地：中国大陆

  • T71395Rohinitib；化合物 RohinitibRohinitib

    Rohinitib, a potent and specific eIF4A inhibitor, effectively induces apoptosis in acute myeloid leukemia (AML) cell lines and decreases the leukemia burden in AML xenograft models. This compound is utilized in the research of AML.

    价 格：￥电议型 号：T71395产 地：中国大陆

  • T71394BMS-823778；化合物 BMS-823778BMS-823778

    BMS-823778 is a potent inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) for the study of type 2 diabetes.

    价 格：￥电议型 号：T71394产 地：中国大陆

  • T71393(S)-FTY-720 Vinylphosphonate；化合物 (S)-FTY-720 Vinylphosphonate(S)-FTY-720 Vinylphosphonate

    (S)-FTY-720 Vinylphosphonate inhibits sphingosine kinase 1 and promotes its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer cells, and androgen-independent prostate cancer cells.

    价 格：￥电议型 号：T71393产 地：中国大陆

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