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  • T73205Praelolide；化合物 PraelolidePraelolide

    Praelolide, a potent Nrf2 activator, disrupts Keap1-Nrf2 protein-protein interactions through noncovalent binding to Keap1, inhibiting osteoclastogenesis and the production of reactive oxygen species (ROS). With its potential in osteoclastogenic bone disease research, Praelolide presents a promising avenue for therapeutic exploration.

    价 格：￥电议型 号：T73205产 地：中国大陆

  • T72205Antiproliferative agent-19；化合物 Antiproliferative agent-19Antiproliferative agent-19

    Antiproliferative Agent-19, an anti-cancer compound, demonstrates antiproliferative effects by inducing apoptosis in lung cancer cells and causing cell cycle arrest in the G2/M phase.

    价 格：￥电议型 号：T72205产 地：中国大陆

  • T72059S1R agonist 2；化合物S1R agonist 2S1R agonist 2

    S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.

    价 格：￥电议型 号：T72059产 地：中国大陆

  • T72058LCDD-1102 HCl；CDD-1102盐酸盐CDD-1102 HCl(2757619-84-2 Free base)；CDD-1102 HCl(2757619-84-2 Free base)

    CDD-1102 HCl is a novel BRDT-BD4 / BRD2-BD1302 selective inhibitor that shows non-hormonal contraceptive potential in ex vivo experiments.

    价 格：￥电议型 号：T72058L产 地：中国大陆

  • T72057H1k；化合物H1kH1k

    H1k is an eudistomin Y fluorescent derivative and lysosome-targeted antiproliferative agent that dose-dependently increases autophagy signalling and down-regulates the expression of cyclin-dependent kinase (CDK1) and cyclin B1.

    价 格：￥电议型 号：T72057产 地：中国大陆

  • T72056KYN-101；化合物 KYN-101KYN-101

    KYN-101 is a potent, selective synthetic antagonist of aryl hydrocarbon receptor (AHR) with IC50 of 22 nM in human HepG2 DRE-luciferase reporter assay and 23 nM in murine Hepa1 Cyp-luc assay.KYN-101 reverses IDO/TDO-mediated tumor progression and improves the efficacy of PD-1 blockade in B16 IDO tumor-bearing mice, as well as CT26 colorectal cancer model expressing endogenous high levels of IDO.

    价 格：￥电议型 号：T72056产 地：中国大陆

  • T72055FM04；化合物FM04FM04

    FM04 is an orally active and highly potent inhibitor of P-glycoprotein (P-gp) with an EC50 value of 83 nM. FM04 can interact with Q1193 and I1115 in human P-gp nucleotide binding domain 2 (NBD2). Thereby disrupting the R262-Q1081-Q1118 interaction pocket and uncoupling the ICL2-NBD2 interaction, thereby inhibiting P-gp. FM04 can be used in the treatment of cancer and tumors.

    价 格：￥电议型 号：T72055产 地：中国大陆

  • T72054SLC26A3-IN-1；化合物SLC26A3-IN-1SLC26A3-IN-1

    SLC26A3-IN-1 is an inhibitor of the anion-exchange protein SLC26A3 with an IC50 value of 340 nM.SLC26A3 is a solute carrier (SLC) protein and a member of the SLC26 family, which has a wide range of anionic specificities for chloride, bicarbonate, sulfate, and oxalate.SLC26A3 is downregulated in adenomas (DRA) and is involved in the intestinal absorption of chloride and oxalate and is associated with chloride-losing diarrhea. SLC26A3 is downregulated in adenomas (DRA), is involved in the intestin

    价 格：￥电议型 号：T72054产 地：中国大陆

  • T72053PERK-IN-6；PERK抑制剂6PERK-IN-6

    PERK-IN-6 is a novel and highly potent PERK inhibitor (IC50:2.5 nM).

    价 格：￥电议型 号：T72053产 地：中国大陆

  • T72051LabMol-319；化合物LabMol-319LabMol-319

    LabMol-319 is a potent Zika virus (ZIKV) NS5 RdRp inhibitor with antiviral activity for the study of ZIKV virus.

    价 格：￥电议型 号：T72051产 地：中国大陆

  • T720504-N-Dodecyloxyphenol；4-正癸氧基苯甲醛4-dodecoxyphenol|||p-Dodecyloxyphenol；4-dodecoxyphenol|||p-Dodecyloxyp

    4-N-Dodecyloxyphenol (p-Dodecyloxyphenol) is a compound that can be used as an additive to ferroelectric or ferroelectric liquid crystals or to display the SmC phase and has no chiral groups.

    价 格：￥电议型 号：T72050产 地：中国大陆

  • T7205A-967079；化合物A 967079TRP Channel|||inhibit|||Transient receptor potential channels|||A967079|||A 9670

    A 967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively.

    价 格：￥电议型 号：T7205产 地：中国大陆

  • T71950PSB-12054；化合物 PSB-12054PSB-12054

    PSB-12054 is a potent P2X4 receptor inhibitor. PSB-12054 has IC(50) of 0.189 μM and good selectivity versus the other human P2X receptor subtypes.

    价 格：￥电议型 号：T71950产 地：中国大陆

  • T71827AG-205；化合物 AG-205AG-205

    (rac)-AG-205 serves as a robust inhibitor of the progesterone receptor membrane component 1 (Pgrmc1), crucial for inducing genes linked to sterol synthesis, notably the INSIG1 protein, which interacts with PGRMC1. Additionally, it plays a pivotal role in mitigating neuronal resistance to hypoxic ischaemia by inhibiting NF-kB signalling and the activation of the BDNF/PI3K/AKT pathway.

    价 格：￥电议型 号：T71827产 地：中国大陆

  • T71026MC2050 HCl；化合物 MC2050 HClMC2050 HCl

    MC2050 is a potent PARP-1 inhibitor. The IC50 for inhibition of PARP-1 activity is 119 nM, compared to 1.8 μM for PARP-2. MC2050 inhibits apoptosis and blocks poly ADP-ribosylation of histone H1 in hydrogen peroxide treated SH-SY5Y neuroblastoma cells.

    价 格：￥电议型 号：T71026产 地：中国大陆

  • T70903KRH102053；化合物 KRH102053KRH102053

    KRH102053 is a HIF-1alpha inhibitor. KRH102053 decreased the protein level of HIF-1alpha and the mRNA levels of HIF-regulated downstream target genes, such as vascular endothelial growth factor, aldolase A, enolase 1 and monocarboxylate transporter 4. Consistent with these results, KRH102053 also inhibited the rates of HIF-related migration and invasion of HOS cells as well as the degree of tube formation in human umbilical vein endothelium cells.

    价 格：￥电议型 号：T70903产 地：中国大陆

  • T70835（4R，9S)-AG 205；化合物（4R，9S)-AG 205（4R，9S)-AG 205

    AG-205 is a potent inhibitor of FabK, the enoyl-ACP reductase in Streptococcus pneumoniae.

    价 格：￥电议型 号：T70835产 地：中国大陆

  • T70470Lisomer-CM 352；CM 352异构体isomer-1542205-83-3；isomer-1542205-83-3

    isomer-CM 352 is a metalase inhibitor that can be used to slow brain damage.

    价 格：￥电议型 号：T70470L产 地：中国大陆

  • T70380ZBH-1205；化合物 ZBH-1205ZBH-1205

    ZBH-1205 is a novel camptothecin derivative, revealing potent antitumor activities mainly through cell apoptosis pathway, being more effective than cpt-11 and sn38 at inhibiting topoismerase-1

    价 格：￥电议型 号：T70380产 地：中国大陆

  • T70330ONO-2050297；化合物 ONO-2050297ONO-2050297

    ONO-2050297 is the first potent dual CysLT1 and CysLT2 antagonist with IC50 values of 0.017 μM (CysLT1) and 0.00087 μM (CysLT2), respectively.

    价 格：￥电议型 号：T70330产 地：中国大陆

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