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T76244Amp1EP9;化合物 Amp1EP9Amp1EP9
Amp1EP9, an antimicrobial peptide, serves as a potent and non-toxic candidate for the development of effective antimicrobial agents. It holds promise for research into multidrug-resistant bacterial infections [1].
价 格:¥电议型 号:T76244产 地:中国大陆
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T76218Targeting the bacterial sliding clamp peptide 46;化合物 Targeting the bacterial sliding clamp peptide 4
Peptide 46 is a short peptide that inhibits SC-dependent DNA synthesis by targeting the bacterial sliding clamp (SC).
价 格:¥电议型 号:T76218产 地:中国大陆
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T75134MC-GGFG-AM-(10Me-11F-Camptothecin);化合物 MC-GGFG-AM-(10Me-11F-Camptothecin)MC-GGFG-AM-(10Me-11F-Campto
MC-GGFG-AM-(10Me-11F-Camptothecin) acts as a linker-payload conjugate in the synthesis of ZW251, an antibody-drug conjugate (ADC) designed to target human GPC3. This ADC comprises a humanized IgG1 antibody attached to ZD06519, a novel camptothecin-based topoisomerase 1 inhibitor, through a maleimide-anchor and a cleavable glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) linker. ZW251 exhibits strong affinity for GPC3 in both human and cynomolgus monkey cells. It is characterized by rap
价 格:¥电议型 号:T75134产 地:中国大陆
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T75023Nampt degrader-2;化合物 Nampt degrader-2Nampt degrader-2
Nampt degrader-2, a fluorescent PROTAC, exhibits efficient degradation of NAMPT at an IC50 of 41.9 nM. It operates by binding to both NAMPT and VHL, initiating the formation of a ternary complex that triggers NAMPT degradation through the ubiquitin-proteasome system (UPS). This activity significantly lowers NAD+ levels and displays potent antitumor effects [1].
价 格:¥电议型 号:T75023产 地:中国大陆
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T74868Uracil-m7GpppAmpG ammonium;化合物 Uracil-m7GpppAmpG ammoniumUracil-m7GpppAmpG ammonium
Uracil-m7GpppAmpG ammonium is a cap analog that can be used for mRNA synthesis.
价 格:¥电议型 号:T74868产 地:中国大陆
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T7467Acid orange 7;酸性橙 7Orange II|||D&,C Orange 4|||COLIPA C015|||2-naphthol orange|||CI 15510;酸性橙 7||
Acid orange 7 (COLIPA C015) is a dye used to dye wool.
价 格:¥电议型 号:T7467产 地:中国大陆
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T74654-Methylbenzylidene camphor;4-甲基苄亚基樟脑Enzacamene|||4-MBC;Enzacamene|||4-甲基苄亚基樟脑|||3-(4-甲基苯亚甲基)樟脑|||4-
4-Methylbenzylidene camphor is an ultraviolet light blocker used in cosmetics and sunscreen preparations ,specifically UV B radiation, also has estrogenic activities.
价 格:¥电议型 号:T7465产 地:中国大陆
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T74615NAMPT degrader-1;化合物 NAMPT degrader-1NAMPT degrader-1
NAMPT Degrader-1 (Compound A3), a nicotinamide phosphoribosyltransferase (NAMPT) degrader, exhibits potent antitumor activity in cells by specifically inducing the degradation of NAMPT via the autophagy-lysosomal pathway, with an inhibitory concentration (IC50) of 0.023 μM [1].
价 格:¥电议型 号:T74615产 地:中国大陆
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T74562Nampt-IN-10 trihydrochloride;化合物 Nampt-IN-10 trihydrochlorideNampt-IN-10 trihydrochloride
Nampt-IN-10 trihydrochloride (Compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor exhibiting cellular potency against A2780 and CORL23 cell lines, with IC50 values of 5 nM and 19 nM, respectively. It holds potential as a novel non-antimitotic payload for antibody-drug conjugate (ADC) [1].
价 格:¥电议型 号:T74562产 地:中国大陆
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T74474m7Gpppm6AmpG ammonium;化合物 m7Gpppm6AmpG ammoniumm7Gpppm6AmpG ammonium
M7Gpppm6AmpG ammonium, a trinucleotide mRNA 5’ cap analog, facilitates in vitro RNA synthesis [1].
价 格:¥电议型 号:T74474产 地:中国大陆
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T74473m7Gpppm6AmpG;化合物 m7Gpppm6AmpGm7Gpppm6AmpG
m7Gpppm6AmpG, a trinucleotide mRNA 5’ cap analog, facilitates RNA synthesis in vitro [1].
价 格:¥电议型 号:T74473产 地:中国大陆
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T74472m7GpppAmpG ammonium;化合物 m7GpppAmpG ammoniumm7GpppAmpG ammonium
m7GpppAmpG ammonium is a trinucleotide 5′ cap analog that exhibits capping efficiencies of 90% for the RNAs obtained [1].
价 格:¥电议型 号:T74472产 地:中国大陆
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T74471m7GpppAmpG;化合物 m7GpppAmpGm7GpppAmpG
M7GpppAmpG is a trinucleotide 5′ cap analog, exhibiting capping efficiencies of 90% for the produced RNAs [1].
价 格:¥电议型 号:T74471产 地:中国大陆
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T74091PBFI-AM;化合物 PBFI-AMPBFI-AM
PBFI-AM is a useful tool to determine intracellular K + content [1] .
价 格:¥电议型 号:T74091产 地:中国大陆
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T74079m-Chloramphenicol;化合物 m-Chloramphenicolm-Chloramphenicol
m-Chloramphenicol (m-threo-Chloramphenicol), an impurity of Chloramphenicol, is a broad-spectrum antibiotic known for its potent capability to inhibit bacterial protein biosynthesis [1].
价 格:¥电议型 号:T74079产 地:中国大陆
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T74061Amphotericin B methyl ester hydrochloride;化合物 Amphotericin B methyl ester hydrochlorideAmphotericin
Amphotericin B methyl ester hydrochloride, a methyl ester derivative of the polyene antibiotic Amphotericin B (A634250), is a cholesterol-binding compound with significant antifungal activity. It disrupts HIV-1 particle production and potently inhibits HIV-1 replication [1] [2].
价 格:¥电议型 号:T74061产 地:中国大陆
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T73891Amphotericin A;化合物 Amphotericin AAmphotericin A
Amphotericin A is a potent antifungal antibiotic [1] .
价 格:¥电议型 号:T73891产 地:中国大陆
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T73873c-di-AMP disodium;化合物 c-di-AMP disodiumc-di-AMP disodium
Cyclic diadenylate (c-di-AMP) sodium functions as a STING agonist by binding to the STING transmembrane protein, thus activating the TBK3-IRF3 signaling pathway. This activation prompts the production of type I IFN and TNF. Additionally, c-di-AMP sodium serves as a bacterial second messenger in Gram-positive bacteria, where it plays crucial roles in regulating cell growth, survival, and virulence, as well as the host immune response. It also acts as a potent mucosal adjuvant by stimulating both
价 格:¥电议型 号:T73873产 地:中国大陆
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T73717cGAMP diammonium;化合物 cGAMP diammoniumcGAMP diammonium
cGAMP (Cyclic GMP-AMPP) diammonium serves as an intrinsic second messenger in metazoans, initiating the production of interferons upon cytosolic DNA detection. It activates the stimulator of interferon genes (STING), subsequently triggering a signaling cascade that culminates in the synthesis of type I interferons and various immune mediators [1] [2] [3] [4].
价 格:¥电议型 号:T73717产 地:中国大陆
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T73708Sp-cAMPS triethylamine;化合物 Sp-cAMPS triethylamineSp-cAMPS triethylamine
Sp-cAMPS triethylamine, a cAMP analog, serves as a potent activator of cAMP-dependent PKA I and II and acts as a competitive inhibitor of phosphodiesterase (PDE3A) with a K i of 47.6 ?M. Additionally, it binds the PDE10 GAF domain with an EC 50 of 40 μM [1] [2] [3].
价 格:¥电议型 号:T73708产 地:中国大陆