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  • T83740Ziptide TFA；化合物 Ziptide TFAZiptide TFA

    Ziptide, a peptide substrate, is recognized by several serine/threonine protein kinases, such as MAPK activated protein kinase 2 (MAPKAPK2), MAPKAPK3, MAPKAPK5, checkpoint kinase 1 (Chk1), AMP-activated protein kinase (AMPK), and calcium/calmodulin-dependent protein kinase II (CamKII). It serves as a tool in evaluating CamKII activity for the development of inhibitors.

    价 格：￥电议型 号：T83740产 地：中国大陆

  • T83739Myr-Tat-CBD3 TFA；化合物 Myr-Tat-CBD3 TFAMyr-Tat-Calcium Channel-binding Domain 3|||N-myristate-Tat-CBD3

    Myr-Tat-CBD3 is a chemical compound that serves as an inhibitor of the protein-protein interaction between the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2). This compound effectively disrupts the Cav2.2-CRMP2 interaction by about 81% at a 10 ?M concentration and demonstrates an inhibitory concentration 50 (IC50) value of approximately 2.8 ?M against potassium-induced calcium influx in primary rat dorsal root ganglion (DRG) neurons. Furthermore, at

    价 格：￥电议型 号：T83739产 地：中国大陆

  • T83738SMAP 29 (ovine) TFA；化合物 SMAP 29 (ovine) TFASheep Myeloid Antimicrobial Peptide 29；Sheep Myeloid Anti

    SMAP 29, a bactericidal antimicrobial peptide and a cleavage product from the C-terminus of an ovine cathelicidin prepropeptide, is effective against P. aeruginosa strain PAO1 in both low- and high-salt conditions, as demonstrated in an energy-dependent luminescence assay with half-maximal effective concentrations (EC50s) of 0.05 and 0.06 ?M, respectively. Additionally, it induces hemolysis in ovine red blood cells in a concentration-dependent manner.

    价 格：￥电议型 号：T83738产 地：中国大陆

  • T83737LRRKtide TFA；化合物 LRRKtide TFAMoesin (550-564)|||Membrane-organizing Extension Spike Protein (550-564

    LRRKtide, a peptide substrate for leucine-rich repeat kinase 2 (LRRK2)—an enzyme often mutated in Parkinson´s disease patients—corresponds to amino acids 550-564 of the membrane-organizing extension spike protein (moesin). It serves to identify inhibitors of LRRK2.

    价 格：￥电议型 号：T83737产 地：中国大陆

  • T83736RTDLDSLRTYTL TFA；化合物 RTDLDSLRTYTL TFARTDLDSLRTYTL TFA

    RTDLDSLRTYTL is a ligand for αVβ6 integrin, exhibiting selective inhibition of fibronectin´s binding to αVβ6 integrin with considerably less effect on the interactions between vitronectin and αVβ3 or αVβ5, as well as fibrinogen and αIIβ3 (IC50s = 0.02, >50, >50, and >50 ?M, respectively). Additionally, it prevents HT-29 colon cancer cells from binding to fibronectin in a concentration-dependent fashion.

    价 格：￥电议型 号：T83736产 地：中国大陆

  • T83735Pap12-6 TFA；化合物 Pap12-6 TFAPap12-6 TFA

    Pap12-6, an antibacterial peptide originating from the first twelve N-terminal amino acids of papiliocin found in P. xuthus larvae, exhibits activity against a range of eight Gram-negative bacteria (e.g., E. coli, P. aeruginosa, S. syphimurium with MIC50s=4-8 ?M) and Gram-positive bacteria (e.g., S. aureus, methicillin-resistant S. aureus 3126, B. subtilis, and S. epidermidis with MIC50s=4-8 ?M), without compromising the viability of human erythrocytes, mouse RAW 264.7 macrophages, human HaCaT k

    价 格：￥电议型 号：T83735产 地：中国大陆

  • T83734PapRIV TFA；化合物 PapRIV TFAPapRIV TFA

    PapRIV, a quorum-sensing heptapeptide derived from B. cereus, undergoes synthesis as a 48-amino acid polypeptide. This compound is secreted and then extracellularly processed by NprB proteases into its active form. At concentrations ranging from 1-25 ?M, PapRIV triggers the production of IL-6 and TNF-α, as well as NF-κB translocation, specifically in BV-2 microglia cells.

    价 格：￥电议型 号：T83734产 地：中国大陆

  • T83733TIP39 (human, bovine) TFA；化合物 TIP39 (human, bovine) TFATuberoinfundibular Peptide of 39 Residues；Tub

    TIP39, a neuropeptide and an agonist for the parathyroid hormone receptor type 2 (PTH2R), effectively increases cAMP levels in COS-7 cells featuring recombinant PTH2R from humans or rats (EC50s = 0.5 and 0.8 nM, respectively), as well as in F-11 cells that naturally express PTH2R (EC50 = 1.15 nM). Furthermore, TIP39 at 1 nM halts the cell cycle at the G0/G1 phase and reduces Sox9 expression, a crucial regulator of cartilage differentiation, in CFK2 rat chondrocytes. Additionally, administering 1

    价 格：￥电议型 号：T83733产 地：中国大陆

  • T83732Tat-CBD3A6K TFA；化合物 Tat-CBD3A6K TFATat-CBD3A6K TFA

    Tat-CBD3A6K, a peptide derivative of the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2) interaction inhibitor Tat-CBD3, has demonstrated efficacy in a rat model of antiretroviral neuropathic pain caused by stavudine (d4T). Administered at 10 mg/kg, it preserves paw withdrawal threshold, indicating pain relief, and reduces the number of action potentials in dorsal root ganglia (DRG) neurons from affected rats. Additionally, a 30 ?M/animal dural dose

    价 格：￥电议型 号：T83732产 地：中国大陆

  • T83731Tat-CBD3 TFA；化合物 Tat-CBD3 TFATat-CBD3 TFA

    Tat-CBD3 is a chemical compound inhibiting the interaction between the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2), as well as the interaction between CRMP2 and the NMDA receptor NR2B subunit. At a concentration of 10 ?M, Tat-CBD3 reduces the Cav2.2-CRMP2 interaction by 43% in cell-free assays and impedes the NMDA receptor NR2B subunit-CRMP2 interaction in immunoprecipitation assays. It lowers voltage-induced calcium currents by about 60% in prim

    价 格：￥电议型 号：T83731产 地：中国大陆

  • T83730Tat-M2NX TFA；化合物 Tat-M2NX TFATat-M2NX TFA

    Tat-M2NX, a peptide antagonist of transient receptor potential melastatin 2 (TRPM2), blocks hydrogen peroxide-induced calcium influx in HEK293 cells expressing human TRPM2 at concentrations between 25 to 100 ?M. In male mice models of stroke caused by middle cerebral artery occlusion (MCAO), Tat-M2NX (20 mg/kg) demonstrates efficacy in reducing brain infarct volume when applied before or 3 hours-post occlusion, yet it shows no such effect in female mice.

    价 格：￥电议型 号：T83730产 地：中国大陆

  • T83729Tat-CIRP TFA；化合物 Tat-CIRP TFATat-Cold-inducible RNA Binding Protein；Tat-Cold-inducible RNA Binding P

    Tat-CIRP, a peptide inhibitor, impedes the protein-protein interaction between myeloid differentiation 2 (MD-2), also known as lymphocyte antigen 96 (LY96), and cold-inducible RNA binding protein (CIRP) by binding to MD-2. This disrupts the MD-2 and CIRP interaction as confirmed in co-immunoprecipitation assays. Notably, in vivo studies reveal that Tat-CIRP, at dosages of 10 and 20 mg/kg, significantly reduces infarct volume in both a mouse model of middle cerebral artery occlusion (MCAO) and a

    价 格：￥电议型 号：T83729产 地：中国大陆

  • T83728Tat-AKAP79 (326-336) TFA；化合物 Tat-AKAP79 (326-336) TFATat-A-kinase Anchor Protein 79 (326-336)；Tat-A-

    Tat-AKAP79 (326-336) is a peptide that links the HIV-1 Tat protein transduction domain with an 11-amino acid sequence from A-kinase anchor protein 79 (AKAP79). This compound effectively inhibits the activation-induced sensitization by protein kinase A (PKA) or PKC of the transient receptor potential vanilloid 1 (TRPV1) at a concentration of 200 ?M in isolated rat dorsal root ganglion (DRG) neurons. Additionally, it mitigates nocifensive behavior in mice elicited by formalin or phorbol 12-myrista

    价 格：￥电议型 号：T83728产 地：中国大陆

  • T83727Tat-NTS Peptide TFA；化合物 Tat-NTS Peptide TFATat-Nuclear Translocation Signal Peptide；Tat-Nuclear Tran

    Tat-NTS peptide, a cell-penetrating compound, comprises the HIV-1 Tat protein transduction domain fused with a 10-amino acid sequence (residues 228-237) from the repeat III domain of annexin A1, serving as a nuclear translocation signal (NTS). This peptide hinders the interaction between annexin A1 and importin β, obstructing annexin A1´s nuclear entry in primary mouse hippocampal neurons. Tat-NTS effectively prevents apoptosis triggered by glucose-oxygen deprivation and reperfusion in the

    价 格：￥电议型 号：T83727产 地：中国大陆

  • T83726Tat-βsyn-degron TFA；化合物 Tat-βsyn-degron TFATat-βsyn-degron TFA

    Tat-βsyn-degron, an α-synuclein knockdown peptide, integrates three domains: the HIV-1 Tat plasma membrane transduction domain, an α-synuclein binding domain (βsyn) representing amino acids 36-45 of β-synuclein, and a proteasomal targeting domain (degron). It effectively binds to recombinant α-synuclein, demonstrating a significant reduction in α-synuclein levels in primary rat cortical neuron cultures.

    价 格：￥电议型 号：T83726产 地：中国大陆

  • T83722FALGPA TFA；化合物 FALGPA TFA2-Furanacryloyl-L-leucylglycyl-L-prolyl-L-alanine|||2-Furanacryloyl-Leu-Gly

    FALGPA, a colorimetric substrate for collagenase, exhibits selectivity over trypsin, thermolysin, and elastase. It uniquely interacts with collagenase, which binds to and cleaves the Leu-Gly (LG) peptide sequence, releasing the furanacryloyl group. This release is measurable through colorimetric detection between 324 and 345 nm, serving as an indicator of collagenase activity. Additionally, FALGPA facilitates the identification of inhibitors for C. histolyticum collagenase.

    价 格：￥电议型 号：T83722产 地：中国大陆

  • T83720Biotin-Crosstide TFA；化合物 Biotin-Crosstide TFABiotin-Gly-Arg-Pro-Arg-Thr-Ser-Ser-Phe-Ala-Glu-Gly-OH；B

    Biotin-crosstide is a derivative of the peptide Akt substrate crosstide, featuring biotinylation.

    价 格：￥电议型 号：T83720产 地：中国大陆

  • T83719Mca-AVLQSGFR-K(Dnp)-K-NH2 TFA；化合物 Mca-AVLQSGFR-K(Dnp)-K-NH2 TFAMca-AVLQSGFR-K(Dnp)-K-NH2 TFA

    Mca-AVLQSGFR-K(Dnp)-K-NH2 serves as a fluorogenic substrate specifically designed for the main protease (Mpro) of the severe acute respiratory syndrome coronavirus (SARS-CoV), also referred to as 3C-like protease (3CLpro). This substrate, upon enzymatic cleavage by SARS-CoV Mpro, liberates 7-methoxycoumarin-4-acetyl (Mca) which emits fluorescence. This fluorescence emission, with excitation/emission peaks at 328/420 nm respectively, facilitates the quantification of SARS-CoV Mpro´s catalyt

    价 格：￥电议型 号：T83719产 地：中国大陆

  • T837185-FAM-LPETGG TFA；化合物 5-FAM-LPETGG TFA5-Carboxyfluorescein-LPETGG；5-Carboxyfluorescein-LPETGG

    5-FAM-LPETGG is a fluorescent peptide that combines the sortase recognition sequence LPETGG with the fluorescent label 5-carboxyfluorescein (5-FAM), characterized by excitation/emission maxima at 492/518 nm. It serves for site-specific labeling of target proteins through sortase-catalyzed transpeptidation.

    价 格：￥电议型 号：T83718产 地：中国大陆

  • T83717Cys-Pexiganan TFA；化合物 Cys-Pexiganan TFACys-Pexiganan TFA

    Cys-pexiganan, a derivative of pexiganan with an added N-terminal cysteine, is an antimicrobial peptide effective against P. aeruginosa and S. aureus, with minimum inhibitory concentrations (MICs) of 64 and 16 ?g/ml, respectively. Its conjugation to cellulose acetate-incorporated polyvinyl alcohol electrospun mats enhances the clotting of isolated recalcified human plasma.

    价 格：￥电议型 号：T83717产 地：中国大陆

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