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  • T8644Elamipretide Triacetate；化合物Elamipretide TriacetateElamipretide TriTFA；Elamipretide TriTFA

    Elamipretide Triacetate (Elamipretide TriTFA) is an aromatic-cationic tetrapeptide that readily penetrates cell membranes and transiently localizes to the inner mitochondrial membrane where it associates with cardiolipin.It has been used in trials studying the treatment of Leber´s Hereditary Optic Neuropathy.

    价 格：￥电议型 号：T8644产 地：中国大陆

  • T8559Galnon TFA(475115-35-6(free base))；化合物Galnon TFAGalnon TFA(475115-35-6(free base))

    Galnon is a novel non-peptide galanin receptor agonist (GAL1 and GAL2 with Ki of 11.7 and 34.1 μM respectively).

    价 格：￥电议型 号：T8559产 地：中国大陆

  • T8556Z-Gly-Gly-Arg-AMC TFA (66216-78-2 free base)；化合物Z-Gly-Gly-Arg-AMC TFAZ-Gly-Gly-Arg-AMC TFA；Z-Gly-Gly

    Z-Gly-Gly-Arg-AMC TFA (66216-78-2 free base) is a thrombin-specific fluorogenic substrate for testing thrombin generation in PRP and platelet-poor plasma (PPP).

    价 格：￥电议型 号：T8556产 地：中国大陆

  • T8552PSEM 89S TFA；化合物PSEM 89S TFAPSEM 89S TFA

    PSEM 89S TFA is a brain-penetrant and selective ion channels agonist, and is orthogonally selective for Q79G and L141F, respectively.

    价 格：￥电议型 号：T8552产 地：中国大陆

  • T83921IMCTA-C14 TFA；化合物 IMCTA-C14 TFAIMCTA-C14 TFA

    IMCTA-C14, a detergent and derivative of the microbial metabolite 4-trehalosamine, exhibits a critical micelle concentration (CMC) of 0.11 mM and a hydrophilic-lipophilic balance (HLB) value of 9.72. It effectively extracts proteins, including membrane proteins, from OVK18 ovarian cancer cells at concentrations of 0.05 and 0.5%. Furthermore, IMCTA-C14 demonstrates antibacterial activity against various bacterial strains (MICs = 8-128 ?g/ml) and shows cytotoxicity against a spectrum of 52 cancer

    价 格：￥电议型 号：T83921产 地：中国大陆

  • T83886icFSP1 TFA；化合物 icFSP1 TFAicFSP1 TFA

    icFSP1, an inhibitor of ferroptosis suppressor protein 1 (FSP1), promotes condensation and phase separation of FSP1 in cellular environments at 2.5 ?M concentration but does not affect FSP1´s enzymatic function in cell-free assessments (IC50 = > 30 ?M). This compound selectively induces ferroptosis in HT-1080 fibrosarcoma cells in a dose-dependent manner. Furthermore, in vivo studies show that icFSP1 administered at 50 mg/kg significantly reduces both the volume and weight of tumors in a B

    价 格：￥电议型 号：T83886产 地：中国大陆

  • T83873Dabigatran Acyl-β-D-Glucuronide TFA；化合物 Dabigatran Acyl-β-D-Glucuronide TFADabigatran β-1-O-Acyl Glu

    Dabigatran acyl-β-D-glucuronide, an active metabolite of the thrombin inhibitor dabigatran, is synthesized predominantly through the action of the UDP-glucuronosyltransferase isoform UGT2B15. This compound, at a concentration of 0.46 ?M, effectively prolongs activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma.

    价 格：￥电议型 号：T83873产 地：中国大陆

  • T83867UNC8153 TFA；化合物 UNC8153 TFAUNC8153 TFA

    UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and NSD3 at 20 ?M, and demonstrating a 50% degradation constant (DC50) of 350 nM. At a concentration of 10 ?M, UNC8153 induces NSD2 degradation and significantly diminishes histone H3 lysine 36 dimethylation (H3K36me2) levels in MM.1S multiple myeloma cells. This degradation effect can be blocked by MLN4924, an inhibitor of the ubiquitin-activating enzyme. Furthermore, UNC815

    价 格：￥电议型 号：T83867产 地：中国大陆

  • T83854BRC4wt TFA；化合物 BRC4wt TFABRC4wt TFA

    BRC4wt, an acetylated peptide originating from the BRC4 repeat within human BRCA2 (1521-1536), acts as an inhibitor of the BRCA2 and RAD51 protein-protein interaction. When linked to the cationic cell-penetrating peptide (Arg)9, it effectively shortens DNA replication tract lengths and diminishes the frequency of homologous repair of camptothecin-induced DNA damage in vitro. Additionally, BRC4wt enhances the efficacy of the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib in inducing cell d

    价 格：￥电议型 号：T83854产 地：中国大陆

  • T83853L-K6L9 TFA；化合物 L-K6L9 TFAL-K6L9 TFA

    L-K6L9, a cytolytic peptide comprised of L-isomer leucine and lysine, demonstrates cytotoxicity against both androgen-independent (LNCaP-CL1) and androgen-dependent (22Rv1 and LNCaP) human prostate cancer cells, with LC50 values of 4, 4, and 6 ?M, respectively. It also affects non-cancerous cells, including NIH3T3 mouse fibroblasts and OL human foreskin fibroblasts, with LC50s of 7 and 5 ?M, respectively. Furthermore, at a concentration of 100 ?M, L-K6L9 induces hemolysis in isolated human eryth

    价 格：￥电议型 号：T83853产 地：中国大陆

  • T83852EGFRvIII Peptide TFA；化合物 EGFRvIII Peptide TFAPEGFRvIII (9-mer)|||Epidermal Growth Factor Receptor Va

    EGFRvIII peptide, a synthetic peptide mirroring the EGFRvIII fusion junction—a tumor-specific, perpetually active EGFR variant missing amino acids 6-273 of the wild-type—binds to HLA-A*0201-positive T2 cells under MHC class I at 25 ?g/ml. It enables antigen presentation in dendritic cells from human peripheral blood mononuclear cells (PBMCs), thus activating CD8+ cytotoxic T lymphocytes and prompting IFN-γ production. Administered at 15 ?g/animal with the TLR5 agonist flagellin B, EGFRvIII pepti

    价 格：￥电议型 号：T83852产 地：中国大陆

  • T83851Tat-QFNP12 TFA；化合物 Tat-QFNP12 TFATat-QFNP12 TFA

    Tat-QFNP12 is a peptide that combines a transcriptional transactivator (Tat) transmembrane domain with an inhibitor targeting the interaction between N-Myc downstream regulated gene 2 (NDRG2) and protein phosphatase Mg2+/Mn2+ dependent 1A (PPM1A). This compound effectively mitigates blood-brain barrier endothelial tight junction disruption caused by elevated levels of matrix metalloproteinase-9 (MMP-9), alleviates cerebral edema, and promotes spontaneous activity along with symmetric limb moveme

    价 格：￥电议型 号：T83851产 地：中国大陆

  • T83850PTD2 TFA；化合物 PTD2 TFAPTD2 TFA

    PTD2, derived from the histone 4 sequence, acts as a peptide inhibitor against Wolf-Hirschhorn syndrome candidate 1 (WHSC1; IC50 = 22 ?M), a histone methyltransferase.

    价 格：￥电议型 号：T83850产 地：中国大陆

  • T83849OP-145 TFA；化合物 OP-145 TFAacetyl-IGKEFKRIVERIKRFLRELVRPLR-amide|||P60.4-Ac；acetyl-IGKEFKRIVERIKRFLREL

    OP-145, a derivative of the antimicrobial peptide LL-37, is a synthetic antimicrobial peptide showing activity against E. coli, P. aeruginosa, C. albicans, and A. niger, with minimum inhibitory concentrations (MICs) of 2, 3, 6, and 18 ?M, respectively. Utilizing poly(lactic-co-glycolic acid) (PLGA) microspheres loaded with OP-145 effectively prevents biofilm formation in a mouse model of bone infection, which is initiated by surgical femoral fracture and subsequent bacterial inoculation at the f

    价 格：￥电议型 号：T83849产 地：中国大陆

  • T83848VnP-16 TFA；化合物 VnP-16 TFAVnP-16 TFA

    VnP-16, a synthetic peptide fragment mirroring amino acids 270-281 of vitronectin (a multifunctional glycoprotein involved in cell attachment, migration, and spreading), promotes attachment and spreading of isolated human osteogenic cells. This effect is reversible with β1 integrin siRNA knockdown when VnP-16 is applied at 9.1 ?g/cm2 on cell plates. The compound enhances osteogenesis in human skin-derived mesenchymal precursors and MC3T3-E1 mouse calvarial osteoblast precursors. Furthermore, in

    价 格：￥电议型 号：T83848产 地：中国大陆

  • T83847SP-A (196-215) (human) TFA；化合物 SP-A (196-215) (human) TFASurfactant Protein A|||SPA4；Surfactant Prot

    Surfactant protein A (SP-A) (196-215) is a synthetic peptide derived from the C-terminal carbohydrate recognition domain of human SP-A, specifically amino acids 196-215. This peptide suppresses LPS-induced TNF-α release in JAWSII mouse dendritic cells at 1 and 10 ?M concentrations and promotes phagocytosis of P. aeruginosa at a 75 ?M concentration. Furthermore, intratracheal administration of SP-A (196-215) at a dose of 50 ?g per animal reduces disease severity and lung colony-forming units in m

    价 格：￥电议型 号：T83847产 地：中国大陆

  • T83846HOXB7 (8-25) TFA；化合物 HOXB7 (8-25) TFAHomeobox B7 (8-25)；Homeobox B7 (8-25)

    HOXB7 (8-25), a peptide fragment derived from homeobox B7 (HOXB7)—a key controller of cell growth and oncogene activator—facilitates antigen presentation when pulsed onto dendritic cells obtained from human peripheral blood mononuclear cells (PBMCs). This process promotes the activation and interferon-gamma (IFN-γ) production by CD4+ helper T cells, triggering targeted and broad-spectrum antitumor responses.

    价 格：￥电议型 号：T83846产 地：中国大陆

  • T83774Shepherdin TFA；化合物 Shepherdin TFALys-His-Ser-Ser-Gly-Cys-Ala-Phe-Leu-OH|||Survivin (79-87)；Lys-His-S

    Shepherdin is a synthetic peptide mirroring amino acids 79-87 of human survivin, acting as an inhibitor of the survivin-heat shock protein 90 (Hsp90) interaction. It specifically targets the N-terminal domain of Hsp90, blocking the survivin-Hsp90 interaction in human reticulocyte extracts at a 150 ?M concentration. Conjugates of Shepherdin with cell-permeable peptides, such as penetratin or the HIV Tat sequence, exhibit anticancer properties both in vitro and in vivo.

    价 格：￥电议型 号：T83774产 地：中国大陆

  • T83770Klotho-derived Peptide 1 (56-87) (human) TFA；化合物 Klotho-derived Peptide 1 (56-87) (human) TFAKP1 (56

    Klotho-derived peptide 1 (KP1) (56-87), a peptide originating from the human Klotho protein, disrupts TGF-β signaling by binding to TGF-β receptor types 1 and 2 (TGFBR1 and TGFBR2; Kds = 1.41 and 14.6 ?M, respectively). Preincubation with KP1 at a concentration of 10 ?g/ml hinders the TGF-β-induced escalation of fibronectin and α-smooth muscle actin (α-SMA) levels in NRK-49F rat fibroblasts. Furthermore, in vivo studies reveal that KP1, administered at 1 mg/kg per day, preferentially accumulates

    价 格：￥电议型 号：T83770产 地：中国大陆

  • T83763EPI-X4 TFA；化合物 EPI-X4 TFAEndogenous Peptide Inhibitor of CXCR4；Endogenous Peptide Inhibitor of CXCR4

    EPI-X4, an endogenous peptide fragment of human serum albumin (amino acids 408-423), serves as an antagonist to the chemokine (C-X-C motif) receptor 4 (CXCR4). It effectively prevents calcium mobilization and receptor internalization triggered by chemokine (C-X-C motif) ligand 12 (CXCL12) in HEK293 cells with CXCR4 expression, at concentrations between 0.8 and 1,000 ?M. Moreover, EPI-X4 hampers the CXCL12-driven migration of both Jurkat T cells and human CD34+ hematopoietic stem cells. In an acu

    价 格：￥电议型 号：T83763产 地：中国大陆

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