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T37830CAY10599CAY10599CAY-10599|||CAY10599
CAY10599 has a wide range of applications in life science related research.
价 格：￥电议型 号：T37830产 地：中国大陆
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T37829CAY10573CAY10573CAY-10573|||CAY10573
The peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors often used as drug targets for the treatment of metabolic disorders. CAY10573 is a PPAR agonist that displays potent binding at PPARα, γ, and δ with IC50 values of 113, 50, and 223 nM, respectively. It potently transactivates PPARα, γ, and δ with EC50 values of 8, 70, and 500 nM, respectively. CAY10573 demonstrates stronger binding and functional activity for PPARγ than the antidiabetic compound ros
价 格：￥电议型 号：T37829产 地：中国大陆
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T37828CAY10514CAY10514CAY-10514|||CAY10514
CAY10514 is an aromatic analog of 8(S)-HETE. It acts as a dual agonist of PPARα and PPARγ with EC50 values of 0.173 and 0.642 μM, respectively.
价 格：￥电议型 号：T37828产 地：中国大陆
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T37464CAY10711CAY10711CAY-10711|||CAY10711
CAY10711 is a substituted diamine that produces rapid bactericidal activity against both Gram-positive and Gram-negative bacteria, including methicillin-resistant S. aureus (MRSA) and stationary-phase bacteria. It displays MIC99 values of 2.9, 11.5, 2.9, and 2.9 μM against S. aureus RN4220, P. aeruginosa PAO1, E. coli ANS1, and MRSA 10082B, respectively. CAY10711 reduces biofilm formation and promotes biofilm dispersal in P. aeruginosa. It is synergistic with kanamycin and has limited adverse ef
价 格：￥电议型 号：T37464产 地：中国大陆
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T37463CAY10704CAY10704CAY10704|||CAY-10704
CAY10704 is a potent inhibitor of hepatitis C virus (HCV) infection (EC50 = 17 nM) that displays low cytotoxicity of virally-infected human hepatoma Huh7.5.1 cells (CC50 = 21.3 μM). It displays good pharmacokinetics in mice when delivered intraperitoneally, with preferential liver distribution without significant hepatotoxicity. CAY10704 is selective for HCV over dengue virus (EC50 = 4.62 μM).
价 格：￥电议型 号：T37463产 地：中国大陆
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T37414CAY10771CAY10771CAY-10771|||CAY10771
CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor δ (PPARδ).1It activates FXR and PPARδ in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 μM, respectively) and is selective for these receptors over retinoic acid receptor α (RARα), retinoid X receptor α (RXRα), PPARα, PPARγ, and liver X receptor α (LXRα) at 10 μM.
价 格：￥电议型 号：T37414产 地：中国大陆
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T37392,6-Dimethoxyquinone；2,6-二甲氧基-1,4-苯醌2,6-Dimethoxy-1,4-benzoquinone|||2,6-Dimethoxy-p-benzoquinone|||
2,6-Dimethoxyquinone (2,6-Dimethoxy-p-benzoquinone) is a member of the class of compounds known as P-benzoquinones. 2,6-Dimethoxyquinone is slightly soluble (in water) and an extremely weak basic (essentially neutral) compound (based on its pKa). It is a benzoquinone, a chemical compound found in Rauvolfia vomitoria, in Tibouchina pulchra, and in common wheat.
价 格：￥电议型 号：T3739产 地：中国大陆
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T37355CAY10703CAY10703CAY10703|||CAY-10703
Dichloroacetate (DCA) is an inhibitor of all pyruvate dehydrogenase kinase (PDHK) isoforms, which are enzymes that phosphorylate and inhibit PDH in mitochondria. Inhibition of PDHK shifts cell metabolism from glycolysis to mitochondrial glucose oxidation, an effect that has relevance to cancer, type 2 diabetes, and other diseases. CAY10703 is a DCA trimer that is at least 10-fold more cytotoxic against leukemia cell lines than DCA. It is approximately 3-fold less cytotoxic than DCA against perip
价 格：￥电议型 号：T37355产 地：中国大陆
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T37353CAY10606CAY10606CAY-10606|||CAY10606
CAY10606 has a wide range of applications in life science related research.
价 格：￥电议型 号：T37353产 地：中国大陆
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T36965CAY10732；化合物CAY10732CAY-10732|||CAY 10732；CAY-10732|||CAY 10732
CAY10732 is a fluorophore for the detection of hydrogen sulfide for H2S imaging in living cells.
价 格：￥电议型 号：T36965产 地：中国大陆
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T36963CAY10503CAY10503CAY-10503|||CAY10503
CAY10503 is a proapoptotic, antiproliferative compound that is able to arrest cell cycle progression in the G0-G1 phase. CAY10503 inhibits the growth of HL60, multidrug resistant HL60R, and K562 cells with IC50 values of 7.0, 23, and 20 μM, respectively. Accumulation of HL60 cells in G0-G1 occurred within eight hours following treatment with 50 μM CAY10503, whereas 10 μM CAY10503 required 96 hours for cell cycle arrest to appear. CAY10503 also induces differentiation of HL60 cells into the follo
价 格：￥电议型 号：T36963产 地：中国大陆
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T36882CAY10773CAY10773CAY10773|||CAY-10773
CAY10773 is a derivative of the ferroptosis inducer sorafenib .1It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 μM, respectively) over non-cancerous HCV-29 cells (IC50= 23.19 μM). CAY10773 induces apoptosis in T24 cells when used at concentrations ranging from 2 to 6 μM but induces ferroptosis at concentrations greater than or equal to 6 μM with 10 hour or longer incubation times. It increases the production of reactive oxygen
价 格：￥电议型 号：T36882产 地：中国大陆
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T36550CAY10535CAY10535CAY10535|||CAY-10535
TPα and TPβ are two isoforms of the human TP receptor, the G protein-coupled receptor (GPCR) that mediates the actions of thromboxane A2 (TXA2). Although their distinct physiological functions have not been fully elucidated, TPβ is believed to be responsible for vascular endothelial growth factor-induced endothelial cell differentiation and migration whereas TPα appears to be the predominant isoform expressed in platelets. CAY10535 is a TP receptor antagonist that shows ~20-fold selectivity for
价 格：￥电议型 号：T36550产 地：中国大陆
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T36457CAY10416CAY10416CAY-10416|||CAY10416
Dual cyclooxygenase-2 (COX-2)/5-lipoxygenase (5-LO) inhibitors are potential therapeutic agents for inflammatory diseases and for prostate cancer. CAY10416 is a dual COX-2/5-LO inhibitor with IC50 values of 50 and 3 nM, respectively. The selectivity of CAY10416 for COX is greater than 200-fold for COX-2 versus COX-1. COX-2/5-LO inhibitors such as CAY10416 are also apoptosis-inducing agents and are potentially useful in prostate cancer chemotherapy. In the PC3 human carcinoma cell line, CAY10416
价 格：￥电议型 号：T36457产 地：中国大陆
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T36197CAY10747CAY10747CAY10747|||CAY-10747
CAY10747 is an inhibitor of the protein-protein interaction between heat shock protein 90 (Hsp90) and cell division cycle 37 (Cdc37) and a derivative of celastrol .1It decreases protein levels of the Hsp90-Cdc37 complex and the Hsp90-Cdc37 clients phosphorylated Akt and Cdk4 in A549 cells when used at a concentration of 5 μM. CAY10747 inhibits proliferation of A549, MCF-7, HOS, and HepG2 cells (IC50s = 0.41, 0.64, 0.9, and 0.94 μM, respectively) and induces apoptosis in A549 cells.
价 格：￥电议型 号：T36197产 地：中国大陆
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T36195CAY10744CAY10744CAY10744|||CAY-10744
CAY10744 is a topoisomerase II-α poison.1 It inhibits topoisomerase II-α by 78.9% when used at a concentration of 20 μM. CAY10744 is selective for topoisomerase II-α over topoisomerase I providing 100 and 0% inhibition, respectively, at 100 μM. It inhibits proliferation of HCT15 colon, T47D breast, DU145 prostate, and HeLa cervical cancer cells (IC50s = 0.014, 0.00267, 0.072, and 2.46 μM, respectively). CAY10744 induces apoptosis in T47D cells when used at concentrations of 10 and 30 μM. CAY1074
价 格：￥电议型 号：T36195产 地：中国大陆
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T36193CAY10717CAY10717CAY10717|||CAY-10717
CAY10717 is a multi-targeted kinase inhibitor that exhibits greater than 40% inhibition of 34 of 104 kinases in an enzymatic assay at a concentration of 100 nM. It has activity at multiple oncogenic kinases, with IC50 values less than 50 nM against wild-type EGFR and ABL and mutant ABLG250E, ABLY253F, ABLE255K, and B-RafV600E. CAY10717 is highly cytotoxic against a cancer cell panel that includes chemotherapy-sensitive and -resistant cell lines (EC50s = 0.4-158 nM). It also inhibits the growth o
价 格：￥电议型 号：T36193产 地：中国大陆
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T36192CAY10682CAY10682CAY10682|||CAY-10682
(±)-Nutlin-3 blocks the interaction of p53 with its negative regulator Mdm2 (IC50 = 90 nM), inducing the expression of p53-regulated genes and blocking the growth of tumor xenografts in vivo. CAY10682 is a pyrrolo[3,4c]pyrazole derivative that inhibits the p53-Mdm2 interaction as potently as (±)-nutlin-3 (Ki = 83 nM) and also dose-dependently reduces activation of the NF-κB pathway. It specifically prevents phosphorylation of IκBα by the kinases IKKα, IKKβ, and IKK (IC50s = 80.5, 78.2, and 57.1
价 格：￥电议型 号：T36192产 地：中国大陆
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T36191CAY10681CAY10681CAY10681|||CAY-10681
Inactivation of the tumor suppressor p53 commonly coincides with increased signaling through NF-κB in cancer. CAY10681 is a dual modulator of p53-MDM2 interaction and NF-κB signaling. It potently binds MDM2 (Ki = 250 nM), reducing MDM2-mediated turnover of p53. CAY10681 also inhibits phosphorylation of IκBα and dose-dependently reduces nuclear accumulation of p65. It blocks the proliferation of cancer cell lines (IC50s range from 33 to 37 μM). CAY10681 exhibits excellent oral bioavailability and
价 格：￥电议型 号：T36191产 地：中国大陆
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T36189CAY10406CAY10406CAY10406|||CAY-10406
CAY10406 is a trifluoromethyl analog of an isatin sulfonamide compound that selectively inhibits caspases 3 and 7. The non-trifluoromethyl compound exhibits Ki values of 1.2 nM and 6 nM for caspases 3 and 7, respectively. For all of the other caspases tested, it is 100 to 1,000 times less potent. Caspases 3 and 7 are ´effector caspases´ that are downstream from the initiating steps of apoptosis, and are implicated in the main proteolytic processing of the apoptotic signal. No data is
价 格：￥电议型 号：T36189产 地：中国大陆
