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T2235Dactolisib；化合物DactolisibBEZ235|||NVP-BEZ235；2-甲基-2-[4-[3-甲基-2-氧代-8-(喹啉-3-基)-2,3-二氢咪唑并[4,5-c]喹啉-1-基]苯
Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).
价 格：￥电议型 号：T2235产 地：中国大陆
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T22137PTP Inhibitor IV；PTP抑制剂IVPTP Inhibitor IV
PTP Inhibitor IV is an effective protein tyrosine phosphatase (PTP) inhibitor, which can selectively inhibit DUSP14 phosphatase activity (IC50.5.21μm). PTP Inhibitor IV inhibited SHP-2, PTP1B, PTp-ε, PTP Meg-2, PTP-σ, PTP-β and PTP-μ, IC50 were 1.8 μM, 2.5 μM, 8.4 μM, 13 μM, 20 μM, 6.4 μM, and 6.7 μM, respectively. PTP Inhibitor IV affects cellular signaling by inhibiting PTP activity and may regulate specific pathways associated with PTP-mediated signaling events.
价 格：￥电议型 号：T22137产 地：中国大陆
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T21691NVP DPP 728 dihydrochloride；化合物 T21691NVP DPP 728 dihydrochloride
NVP-DPP728 is a potent, reversible, nitrile-dependent inhibitor of dipeptidyl peptidase IV (DPP-IV), demonstrating an inhibition constant (K i) of 11 nM for human DPP-IV amidolytic activity. By inhibiting the degradation of glucagon-like peptide-1 (GLP-1), NVP-DPP728 enhances insulin release following glucose intake, making it useful for diabetes research [1].
价 格：￥电议型 号：T21691产 地：中国大陆
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T21303Etoposide Phosphate磷酸依托泊苷Eposin Etopophos Vepesid VP16|||磷酸依托泊苷
Etoposide phosphate is a phosphate salt of Etoposide, which binds to the enzyme topoisomerase II, then induces double-strand DNA breaks and inhibits DNA repair, leading to decreased DNA synthesis and tumor cell proliferation.
价 格：￥电议型 号：T21303产 地：中国大陆
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T2116AEE788；化合物AEE788NVP-AEE 788；NVP-AEE 788
AEE788 (NVP-AEE 788) has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.
价 格：￥电议型 号：T2116产 地：中国大陆
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T2114VER-82576；化合物NVP-BEP800NVP-BEP800；NVP-BEP800
VER-82576 (NVP-BEP800), a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.
价 格：￥电议型 号：T2114产 地：中国大陆
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T1989Luminespib；化合物LuminespibAUY922|||VER-52296|||NVP-AUY922；AUY922|||VER-52296|||NVP-AUY922
Luminespib (VER-52296) is a new-type inhibitor of HSP90 (IC50s: 7.8/21 nM for HSP90α/β in cell free assay).
价 格：￥电议型 号：T1989产 地：中国大陆
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T1975Infigratinib；化合物InfigratinibBGJ-398|||NVP-BGJ398；BGJ-398|||NVP-BGJ398
Infigratinib (NVP-BGJ398) (BGJ398) is an orally bioavailable pan FGFR inhibitor (IC50: 0.9/1.4/1 nM for FGFR1/2/3), >40-fold selective for FGFR versus FGFR4 and VEGFR2.
价 格：￥电议型 号：T1975产 地：中国大陆
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T1963Capmatinib；卡马替尼NVP-INC280|||INC-280|||INCB28060；NVP-INC280|||INC-280|||卡马替尼|||INCB28060
Capmatinib (INCB28060) is an orally bioavailable inhibitor of the proto-oncogene c-Met (HGFR)with potential antineoplastic activity.
价 格：￥电议型 号：T1963产 地：中国大陆
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T19487NVP-BHG712 isomer；化合物NVP-BHG712 isomerNVP-BHG712 isomer
NVP-BHG712 isomer shows conserved non-bonded binding to EPHA2 and EPHB4.
价 格：￥电议型 号：T19487产 地：中国大陆
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T1933NVP 231；化合物NVP 231NVP 231
NVP-231 is a potent, specific and reversible CerK inhibitor(IC50=12±2 nM) that competitively inhibits ceramide binding to CerK.
价 格：￥电议型 号：T1933产 地：中国大陆
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T1926Sonidegib；化合物SonidegibErismodegib|||NVP-LDE225|||LDE225；Erismodegib|||NVP-LDE225|||LDE225
Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.
价 格：￥电议型 号：T1926产 地：中国大陆
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T1918NVP-TAE 226；化合物TAE226TAE226；TAE226
NVP-TAE 226 (TAE226) is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, c-Met, and ALK.
价 格：￥电议型 号：T1918产 地：中国大陆
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T1878XAV-939；化合物XAV939XAV939|||NVP-XAV939；XAV939|||NVP-XAV939
XAV-939 (NVP-XAV939) is a Tankyrase (TNKS) inhibitor that inhibits TNKS1 and TNKS2 (IC50=11/4 nM). XAV-939 selectively inhibits Wnt/β-catenin-mediated transcription.
价 格：￥电议型 号：T1878产 地：中国大陆
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T1827Buparlisib；布帕尼西BKM120|||NVP-BKM120；BKM120|||布帕尼西|||NVP-BKM120
Buparlisib (BKM120) is an orally bioavailable specific oral inhibitor of the pan-class I PI3K (IC50s: 52/166/116/nM for p110α, p110β, and p110δ).
价 格：￥电议型 号：T1827产 地：中国大陆
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T17237VPC 23019；化合物VPC 23019VPC 23019
VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pEC50= 6.58 and 7.07, respectively).
价 格：￥电议型 号：T17237产 地：中国大陆
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T16451PEAQX tetrasodium hydrate；PEAQX四钠水合物NVP-AAM077 tetrasodium hydrate|||PEAQX tetrasodium hydrate (4598
PEAQX tetrasodium hydrate (PEAQX tetrasodium hydrate (459836-30-7 free base)) is an orally available NMDA antagonist that is potent and selective. The IC50 value of PEAQX tetrasodium hydrate (459836-30-7 free base) against hNMDAR 1A/2A was 270 nM and 29600 nM against hNMDAR 1A/2B, respectively.
价 格：￥电议型 号：T16451产 地：中国大陆
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T16365Buparlisib Hydrochloride化合物 T16365NVP-BKM120 Hydrochloride|||BKM120 Hydrochloride
Buparlisib Hydrochloride is an inhibitor of pan-class I PI3K (IC50: 52 nM/166 nM/116 nM/262 nM for p110α/p110β/p110δ/p110γ, respectively).
价 格：￥电议型 号：T16365产 地：中国大陆
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T16364Infigratinib phosphate；磷酸英非替尼NVP-BGJ398 phosphate|||BGJ-398 phosphate；NVP-BGJ398 phosphate|||BGJ-398
Infigratinib phosphate (BGJ-398 phosphate) is an effective inhibitor of the FGFR family (IC50: 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively).
价 格：￥电议型 号：T16364产 地：中国大陆
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T16363NVP-2；化合物NVP-2NVP-2
NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9/CycT activity (IC50: 0.514 nM). NVP-2 shows inhibitory effcts on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases (IC50: 0.584 μM, 0.706 μM, and 0.605 μM, respectively).
价 格：￥电议型 号：T16363产 地：中国大陆
