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  • T70196AZD1446 HCl；化合物 AZD1446 HClAZD1446 HCl

    AZD1446 HCl, also known as TC-6683, is a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders. AZD1446 HCl showed favorable pharmaceutical properties and in vivo efficacy in animal models has been identified as a potential treatment for cognitive deficits associated with psychiatric or neurological conditions and had been evaluated in phase 2 clinical trials as a treatment for Alzheimer´s disease.

    价 格：￥电议型 号：T70196产 地：中国大陆

  • T69970AZD5718；化合物 AZD5718AZD5718

    AZD5718 is a potent and selective FLAP inhibitor (IC50 = 2.0 nM) for Treatment of Coronary Artery Disease. AZD5718 demonstrated a dose dependent and greater than 90% suppression of leukotriene production over 24 h. Preclinical toxicology studies in rat and dog did not show any serious adverse events of clinical significance. Currently, AZD5718 is evaluated in a phase 2a study for treatment of coronary artery disease.

    价 格：￥电议型 号：T69970产 地：中国大陆

  • T69813AZD-6126；化合物 AZD-6126AZD-6126

    AZD6126, also known as ANG-453, a water-soluble phosphate prodrug of N-acetylcolchinol with potential antiangiogenesis and antineoplastic activities. AZD-6126 is an angiogenesis inhibitor and tubulin inhibitor potentially for the treatment of solid tumours. AZD6126 is converted in vivo into N-acetylcolchinol. N-acetylcolchinol binds to and destabilizes the tubulin cytoskeleton of endothelial cells in tumor blood vessels, which may result in tumor endothelial cel apoptosis, the selective occlusio

    价 格：￥电议型 号：T69813产 地：中国大陆

  • T69403AZD-3409；化合物 AZD-3409AZD-3409

    AZD-3409 is a potent prenyl transferase inhibitor. AZD-3409 showed higher potency than lonafarnib. The mean IC(50) for cytotoxicity of AZD3409 was 510 in MEF cells, 10,600 in A549 cells and 6,170 in MCF7 cells, respectively. In these cells, the IC(50) for FTase activity of AZD3409 ranged from 3.0 to 14.2 nM and of lonafarnib from 0.26 to 31.3 nM. AZD3409 inhibits farnesylation to a higher extent than geranylgeranylation. Both inhibition of farnesylation and geranylgeranylation could not be corre

    价 格：￥电议型 号：T69403产 地：中国大陆

  • T69230AZD-1236；化合物 AZD-1236AZD-1236

    AZD1236 is a potent and reversible inhibitor of human MMP-9 and MMP-12 (IC50 = 4.5 and 6.1nM, respectively), with >10-fold selectivity to MMP-2 and MMP-13 and >350-fold selectivity to other members of the enzyme family. AZD1236 activity is approximately 20 to 50-fold lower at the rat, mouse, and guinea pig orthologues. In acute models of lung injury, AZD1236 inhibited the haemorrhage and inflammation induced by instillation of human MMP-12 into rat lungs by ~80% at 0.81mg/kg, and also abolished

    价 格：￥电议型 号：T69230产 地：中国大陆

  • T68743AZD4877 HCl；化合物 AZD4877 HClAZD4877 HCl

    AZD4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. KSP inhibitor AZD4877 selectively inhibits microtubule motor protein KSP (also called kinesin-5 or Eg5), which may result in the inhibition of mitotic spindle assembly; activation of the spindle assembly checkpoint; induction of cell cycle arrest during the mitotic phase; and cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neur

    价 格：￥电议型 号：T68743产 地：中国大陆

  • T68515AZD-1175；化合物 AZD-1175AZD-1175

    AZD-1175 is a cannabinoid receptor CB1 antagonist and highly lipophilic compound for the treatment of type 2 diabetes and obesity.

    价 格：￥电议型 号：T68515产 地：中国大陆

  • T68500AZD-2207；化合物 AZD-2207AZD-2207

    AZD-2207 is a cannabinoid receptor CB1 antagonist and highly lipophilic compound for the treatment of type 2 diabetes mellitus and obesity.

    价 格：￥电议型 号：T68500产 地：中国大陆

  • T68403AZD-6918；化合物 AZD-6918AZD-6918

    AZD6918 is a novel potent and selective inhibitor of the Trk tyrosine kinases. AZD-6918 attenuates the BDNF/TrkB-induced protection of neuroblastoma cells from etoposide in vitro and in vivo. AZD6918 inhibited wild-type TrkB-induced cell migration and cell growth.

    价 格：￥电议型 号：T68403产 地：中国大陆

  • T68331AZD-3199 dihydrobromide；化合物 AZD-3199 dihydrobromideAZD-3199 dihydrobromide

    AZD-3199 dihydrobromide is a β2 adrenergic receptor agonist potentially for the treatment of asthma and chronic obstructive.

    价 格：￥电议型 号：T68331产 地：中国大陆

  • T68305AZD-2066 sulfate；化合物 AZD-2066 sulfateAZD-2066 sulfate

    AZD-2066 sulfate is an orally bioavailable and brain penetrant mGlu5 antagonist.

    价 格：￥电议型 号：T68305产 地：中国大陆

  • T68304AZD-2066 hydrochloride；化合物 AZD-2066 hydrochlorideAZD-2066 hydrochloride

    AZD-2066 hydrochloride is an mGlu5 antagonist.

    价 格：￥电议型 号：T68304产 地：中国大陆

  • T68281AZD-1386；化合物 AZD-1386AZD-1386

    AZD1386 is an orally available antagonist of the transient receptor potential channel TRPV1. Note: Structure of this product was from NIH/NCATS web page: https://drugs.ncats.io/drug/210323T9CP and drugbank web page: https://go.drugbank.com/drugs/DB15333.

    价 格：￥电议型 号：T68281产 地：中国大陆

  • T68271AZD1386；化合物 AZD1386AZD1386

    AZD1386 is a TRPV1 antagonist. AZD1386 acts as a competitive antagonist at the channel´s capsaicin binding site.

    价 格：￥电议型 号：T68271产 地：中国大陆

  • T68240AZD-9819；化合物 AZD-9819AZD-9819

    AZD-9819 is an inhibitor of human neutrophil elastase for potential treatment of chronic obstructive pulmonary disease (COPD).

    价 格：￥电议型 号：T68240产 地：中国大陆

  • T68173ZD-2138；化合物Zd-2138Ici-D2138；Ici-D2138

    ZD-2138 is a potent and selective specific inhibitor of 5-lipoxygenase (5-LOX) that inhibits allergen-induced pulmonary bronchoconstriction and reduces neurally-induced fast-acting kallikrein-ergic constriction of isolated airways in guinea pigs.ZD-2138 can be used for the treatment of asthma disease.

    价 格：￥电议型 号：T68173产 地：中国大陆

  • T6774AZD-8835；化合物AZD8835AZD8835；AZD8835

    AZD-8835 is a mixed inhibitor of PI3Kα/δ (IC50: 6.2/5.7 nM), also with selectivity against PI3Kβ/γ (IC50: 431/90 nM).

    价 格：￥电议型 号：T6774产 地：中国大陆

  • T6773AZD8186；化合物AZD8186AZD8186

    AZD8186 is an effective and specific PI3Kβ/δ inhibitor (IC50: 4/12 nM).

    价 格：￥电议型 号：T6773产 地：中国大陆

  • T6772AZD3839 free base；化合物AZD3839AZD3839；AZD3839

    AZD3839 free base is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.

    价 格：￥电议型 号：T6772产 地：中国大陆

  • T6771AZD3264；化合物AZD3264AZD3264

    AZD3264 is a new type IKK2 inhibitor.

    价 格：￥电议型 号：T6771产 地：中国大陆

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