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T18601Desmethyl-QCA276；化合物 T18601PROTAC BRD4-binding moiety 4；PROTAC BRD4-binding moiety 4
Desmethyl-QCA276, the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM, and with a Ki of 2.3 nM[1].
价 格：￥电议型 号：T18601产 地：中国大陆
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T18599PROTAC BRD4-binding moiety 1；化合物 T18599PROTAC BRD4-binding moiety 1
PROTAC BRD4-binding moiety 1 is a BRD4 ligand that binds to the cereblon ligand through a linker, enabling the formation of a PROTAC complex. This complex efficiently degrades BRD4[1].
价 格：￥电议型 号：T18599产 地：中国大陆
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T18598PROTAC BRD2/BRD4 degrader-1；化合物 T18598PROTAC BRD2/BRD4 degrader-1
PROTAC BRD2/BRD4 degrader-1 (compound 15) serves as a potent, selective degrader of BET proteins BRD4 and BRD2, achieving rapid, reversible, and unexpectedly selective elimination of BRD4 and BRD2 compared to BRD3. Its efficacy in suppressing solid tumors manifest with minimal cytotoxic effects. This compound comprises a BET inhibitor, a connecting linker, and thalidomide as the ligand for cereblon (CRBN)/cullin 4A[1].
价 格：￥电议型 号：T18598产 地：中国大陆
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T18595Dasatinib carbaldehyde；化合物Dasatinib carbaldehydePROTAC ABL binding moiety 4|||BMS-354825 carbaldehyd
Dasatinib carbaldehyde (PROTAC ABL binding moiety 4) is based on Dasatinib which is an ABL inhibitor, binds to the IAP ligand via a linker, and forms SNIPER [1].
价 格：￥电议型 号：T18595产 地：中国大陆
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T18594HG-7-85-01-Decyclopropane；化合物 T18594PROTAC ABL binding moiety 3；PROTAC ABL binding moiety 3
Decyclopropane, also known as HG-7-85-01, is a chemical compound with ABL inhibitor properties. It binds to the IAP ligand through a linker, resulting in the formation of SNIPER [1].
价 格：￥电议型 号：T18594产 地：中国大陆
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T18593GNF5-amido-Me；化合物 T18593PROTAC ABL binding moiety 2；PROTAC ABL binding moiety 2
GNF5-amido-Me, the moiety based on GNF5 (ABL inhibitor),binds through a linker to the IAP ligand forming SNIPER[1].
价 格：￥电议型 号：T18593产 地：中国大陆
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T18592Imatinib carbaldehyde；化合物 T18592CGP-57148B carbaldehyde|||STI571 carbaldehyde|||PROTAC ABL binding m
Imatinib carbaldehyde (also known as CGP-57148B carbaldehyde) is a compound derived from Imatinib, an inhibitor of the ABL protein. Imatinib carbaldehyde binds to the IAP ligand with the assistance of a linker, resulting in the formation of SNIPER[1].
价 格：￥电议型 号：T18592产 地：中国大陆
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T18515Palbociclib-propargyl；化合物 T18515PROTAC CDK6 ligand 1；PROTAC CDK6 ligand 1
Palbociclib-propargyl, a PROTAC ligand targeting the protein CDK6, connects to the CRBN ligand through a PEG linker to form PROTAC CP-10. CP-10 exhibits a potent DC50 value of 2.1 nM against CDK6[1].
价 格：￥电议型 号：T18515产 地：中国大陆
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T17996VH032-PEG5-C6-Cl；化合物 T17996HaloPROTAC 2；HaloPROTAC 2
VH032-PEG5-C6-Cl (HaloPROTAC 2) is a small molecule HaloPROTAC that incorporates the VH032 based VHL ligand and 5-unit PEG linker. VH032-PEG5-C6-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
价 格：￥电议型 号：T17996产 地：中国大陆
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T17995Halo PROTAC 1；化合物 T17995Halo PROTAC 1
Halo PROTAC 1 is a PROTAC, which is a ligand having activity to bind to an intracellular proteins fused with HaloTag and a structure having activity to induce autophagy of an intracellular molecule are linked via a PEG linker[1].
价 格：￥电议型 号：T17995产 地：中国大陆
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T17728PROTAC CDK9 degrader-2；化合物 T17728PROTAC CDK9 degrader-2
PROTAC CDK9 degrader-2 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1].
价 格：￥电议型 号：T17728产 地：中国大陆
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T17722Cbz-NH-PEG3-CH2COOH；苯甲氧羰酰基二聚乙二醇羧乙基Inhibitor|||PROTAC Linkers|||inhibit|||CbzNHPEG3CH2COOH|||Cbz-NH-P
Cbz-NH-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
价 格：￥电议型 号：T17722产 地：中国大陆
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T16667PROTAC Sirt2 Degrader-1；化合物 T16667PROTAC Sirt2 Degrader-1
PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s > 100 μM)[1].
价 格：￥电议型 号：T16667产 地：中国大陆
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T16666NH2-PEG3-C1-Boc化合物 T16666PROTAC Linker 5
NH2-PEG3-C1-Boc, also known as PROTAC Linker 5, is a polyethylene glycol (PEG)-based linker utilized in the synthesis of proteolysis targeting chimeras (PROTACs)[1].
价 格：￥电议型 号：T16666产 地：中国大陆
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T16665Triethylene glycol；化合物 T16665PROTAC Linker 25；PROTAC Linker 25
Triethylene glycol (PROTAC Linker 25) is a polyethylene glycol (PEG) derivative commonly employed as a linker in the synthesis of proteolysis targeting chimeras (PROTACs)[1].
价 格：￥电议型 号：T16665产 地：中国大陆
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T16664N3-PEG4-C2-NH2化合物 T16664PROTAC Linker 20
N3-PEG4-C2-NH2 (PROTAC Linker 20) is a PEG-based linker compound utilized for the synthesis of PROTACs. Its chemical structure enables efficient conjugation and serves as a bridging element between the target protein and the E3 ligase, facilitating targeted protein degradation[1].
价 格：￥电议型 号：T16664产 地：中国大陆
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T16663Bis-NH2-PEG2；化合物 T16663PROTAC Linker 19；PROTAC Linker 19
Bis-NH2-PEG2 (PROTAC Linker 19) is a PEG-based linker compound utilized for the synthesis of PROTACs.
价 格：￥电议型 号：T16663产 地：中国大陆
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T16662Tetraethylene glycol三缩四乙二醇PROTAC Linker 18|||三缩四乙二醇
Tetraethylene glycol (PROTAC Linker 18) is a polyethylene glycol (PEG)-based linker that finds utility in the synthesis of PROTACs[1].
价 格：￥电议型 号：T16662产 地：中国大陆
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T16661NH2-PEG5-C2-NH-Boc；化合物 T16661PROTAC Linker 17；PROTAC Linker 17
NH2-PEG5-C2-NH-Boc (PROTAC Linker 17) is a PEG-based compound utilized as a linker in the synthesis of PROTACs[1].
价 格：￥电议型 号：T16661产 地：中国大陆
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T16660N3-PEG3-CH2COOH；化合物 T16660N-3-PEG3-CH2COOH|||N3 PEG3 CH2COOH|||PROTAC Linker 14|||N3-PEG3-CH2COOH|||
N3-PEG3-CH2COOH (PROTAC Linker 14) is a PEG-based compound utilized for the synthesis of PROTACs.
价 格：￥电议型 号：T16660产 地：中国大陆
