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  • T81890Macedonoside A；化合物 Macedonoside AMacedonoside A

    Macedonoside A (compound 3), a saponin, is isolated from the stolons of Glycyrrhiza lepidota [1].

    价 格：￥电议型 号：T81890产 地：中国大陆

  • T8189Dihydroberberine；二氢小檗碱Dihydroberberine

    Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities. It inhibits human ether-a-go-go-related gene (hERG) channels and remarkably reduces Hsp90 expression and its interaction with hERG.

    价 格：￥电议型 号：T8189产 地：中国大陆

  • T81189Schizolaenone C；化合物 Schizolaenone CSchizolaenone C

    Schizolaenone C, a natural compound isolated from Schizolaena hystrix, demonstrates anti-proliferative and anti-oxidative properties [1] [2].

    价 格：￥电议型 号：T81189产 地：中国大陆

  • T80189Hainantoxin-IV；化合物 Hainantoxin-IVHNTX-IV；HNTX-IV

    Hainantoxin-IV acts as a specific antagonist for tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels, with His28 and Lys32 being critical residues for binding to the target. This compound also features an inhibitor cystine knot motif [1].

    价 格：￥电议型 号：T80189产 地：中国大陆

  • T79667YCH1899；化合物 YCH1899YCH1899

    YCH1899, an orally active PARP inhibitor, demonstrates potent inhibition of PARP1/2 with an IC50 of less than 0.001 nM. It shows marked antiproliferative efficacy against Olaparib-resistant (Capan-1/OP) and Talazoparib-resistant (Capan-1/TP) cells with IC50 values of 0.89 nM and 1.13 nM, respectively. Moreover, YCH1899 possesses favorable pharmacokinetic attributes in rats [1].

    价 格：￥电议型 号：T79667产 地：中国大陆

  • T791891-Isopropyltryptophan；化合物 1-Isopropyltryptophan1-IsoPT；1-IsoPT

    1-Isopropyltryptophan (1-IsoPT), an IDO1 inhibitor, suppresses the expression of IDO-1 and IDO-2 mRNA induced by IFN-γ stimulation [1].

    价 格：￥电议型 号：T79189产 地：中国大陆

  • T79137Monlunabant；化合物 Monlunabant(S)-MRI-1891；(S)-MRI-1891

    Monlunabant ((S)-MRI-1891), a solid dispersion compound, functions as an inhibitor of the cannabinoid CB1 receptor [1].

    价 格：￥电议型 号：T79137产 地：中国大陆

  • T78189JAK-IN-26；化合物 JAK-IN-26JAK-IN-26

    JAK-IN-26 (compound 2) is an orally active inhibitor of the Janus kinase (JAK) enzyme with favorable pharmacokinetic properties, exhibiting potency in suppressing IFN-α2B-induced STAT3 phosphorylation in Jurkat cells with an IC50 value of 17.2 nM [1].

    价 格：￥电议型 号：T78189产 地：中国大陆

  • T78041Tat-peptide control 168-189 TFA；化合物 Tat-peptide control 168-189 TFATat-peptide control 168-189 TFA

    Tat-peptide 168-189, a cell-permeable, Tat-labeled fusion peptide derived from residues 168-189 of rat G3BP1, features the HIV Tat sequence at its least conserved terminus to enhance cellular uptake. It serves as the negative control for Tat-peptide 168-189 TFA, which promotes axon growth and neurite proliferation [1].

    价 格：￥电议型 号：T78041产 地：中国大陆

  • T77768BAY 1892005；化合物BAY 1892005BAY 1892005

    BAY 1892005 is a p53 protein modulator that targets the p53 condenser for the study of diseases associated with misfolded p53 protein

    价 格：￥电议型 号：T77768产 地：中国大陆

  • T77672JI069；化合物JI069WAY-354189；WAY-354189

    JI069 (WAY-354189) is a potent STAT3 inhibitor that inhibits gp130 signaling by inducing dissociation between gp130 and JAK1.

    价 格：￥电议型 号：T77672产 地：中国大陆

  • T77189Sudubrilimab；化合物 SudubrilimabSudubrilimab

    Sudubrilimab (HS636), an Ig G1-kappa monoclonal antibody targeting PDL1, is engineered with a TGF-β1 receptor II ectodomain (TGFBR2-ECD) fused to its C-terminus. This design enables Sudubrilimab to simultaneously inhibit the PD-1/PD-L1 pathway and TGF-β bioactivity within the immunosuppressive tumor microenvironment [1].

    价 格：￥电议型 号：T77189产 地：中国大陆

  • T76189Phyllomedusin；化合物 PhyllomedusinPhyllomedusin

    Phyllomedusin, a tachykinin decapeptide, acts as an NK1 receptor agonist. It exhibits vasodilatory effects and induces pyloric contractions [1] [2] [3].

    价 格：￥电议型 号：T76189产 地：中国大陆

  • T751895-Caroxy uracil-1-yl acetic acid benzyl ester；化合物 5-Caroxy uracil-1-yl acetic acid benzyl ester5-Car

    5-Caroxy uracil-1-yl acetic acid benzyl ester, a purine nucleoside analog, exhibits broad antitumor activity primarily against indolent lymphoid malignancies. Its anticancer mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, among others [1].

    价 格：￥电议型 号：T75189产 地：中国大陆

  • T73462MK-8189；化合物 MK-8189MK-8189

    MK-8189 is a potent, orally active, and selective inhibitor of Phosphodiesterase 10A (PDE10A), exhibiting a K i value of 29 pM. It has potential applications in the research of schizophrenia.

    价 格：￥电议型 号：T73462产 地：中国大陆

  • T73347BCX-1898；化合物 BCX-1898BCX-1898

    BCX-1898, a selective cyclopentane-derived, orally active influenza virus neuraminidase inhibitor, exhibits antiviral activity by inhibiting the replication of influenza A (H1N1, H3N2, H5N1) and influenza B viruses in MDCK cells, with EC50 values ranging from <0.01 to 21 μM. It demonstrates protective effects in the mouse influenza model.

    价 格：￥电议型 号：T73347产 地：中国大陆

  • T73189Ficonalkib；化合物 FiconalkibFiconalkib

    Ficonalkib is a potent antineoplastic agent that inhibits the Anaplastic Lymphoma Kinase (ALK) tyrosine kinase receptor.

    价 格：￥电议型 号：T73189产 地：中国大陆

  • T7318Elimusertib；化合物BAY-1895344BAY-1895344；BAY-1895344

    Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride.

    价 格：￥电议型 号：T7318产 地：中国大陆

  • T72979LEM-14-1189；化合物LEM-14-1189LEM-14-1189

    Lem-14-1189, a LEM-14 derivative, is a potent NSD inhibitor of the nuclear receptor binding SET domain, and has inhibitory effects on NSD1, NSD2, and NSD3, with IC50 of 418 μM, 111 μM, and 60 μM, respectively. LEM-14-1189 has potential anticancer activity and can be used to study multiple myeloma (MM) and diseases of the blood system.

    价 格：￥电议型 号：T72979产 地：中国大陆

  • T71899Verubecestat TFA；化合物 Verubecestat TFAVerubecestat TFA

    Verubecestat TFA, also known as MK-8931 or SCH 900931, is a potent and selective beta-secretase inhibitor, and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor. Verubecestat TFA is a promising novel therapeutic drug candidate in Alzheimer´s disease. Verubecestat TFA reduced Aβ cerebral spinal fluids (CSF) levels up to 92% and was well tolerated by patients.

    价 格：￥电议型 号：T71899产 地：中国大陆

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