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T16544Pivalopril；化合物 T16544Pivopril|||RHC 3659(S)；Pivopril|||RHC 3659(S)
Pivalopril is a new orally active inhibitor of angiotensin-converting enzyme.
价 格：￥电议型 号：T16544产 地：中国大陆
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T16499Mardepodect；化合物MardepodectPF-2545920；PF-2545920
Mardepodect (PF-2545920) is a phosphodiesterase inhibitor selective for the PDE10A subtype with an IC50 of 0.37 nM, >1000-fold selectivity over PDE. It is potentially useful for the treatment of schizophrenia. Phosphodiesterase 10A (PDE10A) is highly expressed in striatal medium spiny neurons of both the direct and indirect output pathways. Mardepodect can cross the blood-brain barrier.
价 格：￥电议型 号：T16499产 地：中国大陆
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T16492PF-06459988；化合物PF-06459988PF-06459988
PF-06459988 is a novel, effective, orally active, irreversible, and selective epidermal growth factor receptor (EGFR) mutant inhibitor. PF-06459988 has high efficiency and high affinity for EGFRs double mutants containing T790M, and has minimal activity against WT EGFR. PF-06459988 makes a candidate drug for the treatment of cancer.
价 格：￥电议型 号：T16492产 地：中国大陆
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T16459PEG4-Ms；化合物 T16459PEG4-Ms
PEG4-Ms is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格：￥电议型 号：T16459产 地：中国大陆
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T16451PEAQX tetrasodium hydrate；PEAQX四钠水合物NVP-AAM077 tetrasodium hydrate|||PEAQX tetrasodium hydrate (4598
PEAQX tetrasodium hydrate (PEAQX tetrasodium hydrate (459836-30-7 free base)) is an orally available NMDA antagonist that is potent and selective. The IC50 value of PEAQX tetrasodium hydrate (459836-30-7 free base) against hNMDAR 1A/2A was 270 nM and 29600 nM against hNMDAR 1A/2B, respectively.
价 格：￥电议型 号：T16451产 地：中国大陆
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T16427Padsevonil；帕塞沃尼UCB-0942|||UCB1415943-000；UCB-0942|||UCB1415943-000
Padsevonil (UCB-0942) is a potential GABA A receptor orthosteric modulator with antiepileptic activity for the treatment of epilepsy.
价 格：￥电议型 号：T16427产 地：中国大陆
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T16359NU6140；化合物NU6140NU6140
NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also enhances the apoptotic effect and has anti-cancer activity.
价 格：￥电议型 号：T16359产 地：中国大陆
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T16339Norverapamil hydrochloride；盐酸去甲维拉帕米(±)-Norverapamil hydrochloride|||D591 hydrochloride；(±)-Norverapa
Norverapamil hydrochloride (D591 hydrochloride) ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.
价 格：￥电议型 号：T16339产 地：中国大陆
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T16280Nedocromil尼多克罗FPL 59002|||尼多克罗
Nedocromil (FPL 59002) inhibits the action or formation of multiple mediators. Which including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).
价 格：￥电议型 号：T16280产 地：中国大陆
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T16259N3-PEG4-C2-NHS ester；化合物 T16259N3-PEG4-C2-NHS ester
N3-PEG4-C2-NHS ester is a four-unit polyethylene glycol (PEG) linker that is noncleavable, serving as a crucial component in the synthesis of antibody-drug conjugates (ADCs).
价 格：￥电议型 号：T16259产 地：中国大陆
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T16159Muramyl dipeptide；佐剂肽MDP；MDP
Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide indirectly decreases osteoclast differentiation through a decreased RANKL/OPG ratio. Muramyl dipeptide directly increases osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide is an inducer of bone formation through the induction of Runx2 .
价 格：￥电议型 号：T16159产 地：中国大陆
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T16141MRT00033659；化合物 T16141MRT00033659
MRT00033659 is an effective broad-spectrum kinase inhibitor of CK1 (IC50=0.9 μM for CK1δ) and CHK1 (IC50=0.23 μM). MRT00033659 is a pyrazolo-pyridine analogue. It also induces p53 pathway activation and E2F-1 destabilization.
价 格：￥电议型 号：T16141产 地：中国大陆
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T1610Metaxalone；美他沙酮Skelaxin|||Methaxalonum|||Zorane|||NSC170959|||AHR438；Skelaxin|||Methaxalonum|||美他沙酮|
Metaxalone (Methaxalonum) (marketed by King Pharmaceuticals under the brand name Skelaxin ) is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions.
价 格：￥电议型 号：T1610产 地：中国大陆
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T16098Islatravir；化合物IslatravirMK-8591；MK-8591
Islatravir (MK-8591) is an effective anti-HIV-1 agent. It acts as a nucleoside reverse transcriptase inhibitor (EC50s: 0.068 nM, 3.1 nM, and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively).
价 格：￥电议型 号：T16098产 地：中国大陆
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T16087Quiflapon；喹夫拉朋MK-591；喹夫拉朋|||MK-591
Quiflapon (MK-591) causes cell apoptosis. Quiflapon is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor (IC50: 1.6 nM in a FLAP binding assay) and is also an effective and orally active Leukotriene biosynthesis (LT) inhibitor (IC50: 3.1 and 6.1 nM in intact human and elicited rat PMNLs, respectively).
价 格：￥电议型 号：T16087产 地：中国大陆
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T16059Methyltetrazine-PEG5-alkyne；化合物 T16059Methyltetrazine-PEG5-alkyne
Methyltetrazine-PEG5-alkyne, a PEG-based PROTAC linker, is utilized in synthesizing PROTACs[1].
价 格：￥电议型 号：T16059产 地：中国大陆
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T16039Ibodutant；化合物 T16039MEN 15596；MEN 15596
Ibodutant is an effective and selective tachykinin NK2 receptor antagonist (pKi: 10.1).
价 格：￥电议型 号：T16039产 地：中国大陆
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T16022Arhalofenate；芳卤芬酯JNJ 39659100|||MBX 102；JNJ 39659100|||芳卤芬酯|||4-氯-ALPHA-[3-(三氟甲基)苯氧基]苯乙酸 2-(乙酰基氨基)乙酯
Arhalofenate (JNJ 39659100) is a selective partial agonist of peroxisome proliferator-activated receptor PPARγ. It is used for the treatment of type 2 diabetes.
价 格：￥电议型 号：T16022产 地：中国大陆
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T15999Mal-PEG6-acid；化合物 T15999Mal-PEG6-acid
Mal-PEG6-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格：￥电议型 号：T15999产 地：中国大陆
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T15998Mal-PEG5-PFP ester；化合物 T15998Mal-PEG5-PFP ester
Mal-PEG5-PFP ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格：￥电议型 号：T15998产 地：中国大陆
