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  • T39105Ibiglustat succinateIbiglustat succinateGZ402671succinate|||Venglustat succinate|||Ibiglustat succin

    Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant inhibitor of glucosylceramide synthase (GCS). It is utilized in the investigation of Gaucher disease type 3, Parkinson´s disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease.

    价 格:¥电议型 号:T39105产 地:中国大陆

  • T38838QS-21;QS-21Stimulon|||QS-21;Stimulon|||QS-21

    QS-21, an immunostimulatory saponin, is a powerful vaccine adjuvant that stimulates both Th2 humoral and Th1 cell-mediated immune responses by interacting with antigen presenting cells (APCs) and T cells. Additionally, QS-21 activates the NLRP3 inflammasome, leading to the release of cytokines IL-1β and IL-18, which are dependent on caspase-1.

    价 格:¥电议型 号:T38838产 地:中国大陆

  • T38835STK33-IN-1STK33-IN-1STK33-IN-1

    STK33-IN-1 (compound 1) is a STK33 inhibitor, with an IC 50 of 7 nM.

    价 格:¥电议型 号:T38835产 地:中国大陆

  • T38168S.pombe lumazine synthase-IN-1;S.pombe lumazine synthase-IN-1S.pombe lumazine synthase-IN-1

    S.pombe lumazine synthase-IN-1 is a compound that inhibits lumazine synthases, demonstrating Ki values of 243 μM for Schizosaccharomyces pombe and 9.6 μM for Mycobacterium tuberculosis, respectively[1].

    价 格:¥电议型 号:T38168产 地:中国大陆

  • T38161STING Agonist C11;STING Agonist C11STING Agonist C11;STING Agonist C11

    STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1β, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o´nyong-nyong, Mayaro, and Ross River virus

    价 格:¥电议型 号:T38161产 地:中国大陆

  • T38158StA-IFN-1StA-IFN-1StA IFN 1|||StAIFN1

    StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 μM in a GFP reporter assay for IFN induction similar to TPCA-1 , which specifically inhibits the IKKβ component of the IFN induction pathway. It does not show inhibitory activity in a GFP reporter assay for IFN signaling in which ruxolitinib , which is specific for the IFN signaling component JAK1, is active. StA-IFN-1 reduces the levels of IFN-β, but not ISG MxA, mRNA, suggesting that it is selective f

    价 格:¥电议型 号:T38158产 地:中国大陆

  • T37450SSK1;化合物 SSK1SSK1;SSK1

    SSK1 is a compound that selectively kills senescent cells and is a precursor for β-galactosidase, which can reduce the inflammatory response of the body. SSK1 can activate the phosphorylation of p38 MAPK and MKK3/MKK6 in senescent cells, and promote mitochondrial DNA damage in senescent cells.

    价 格:¥电议型 号:T37450产 地:中国大陆

  • T36942SSAA09E1;SSAA09E1SSAA09E1;SSAA09E1

    SSAA09E1 is an inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) viral entry.1It reduces infection of HEK293T cells transiently transfected with angiotensin-converting enzyme 2 (ACE2) by an HIV-based virus system pseudotyped with SARS-CoV surface glycoprotein (EC50= 6.7 μM). SSAA09E1 also inhibits the proteolytic activity of cathepsin L (IC50= 5.33 μM) but not cathepsin B when used at a concentration of 20 μM.

    价 格:¥电议型 号:T36942产 地:中国大陆

  • T3688SR9011;化合物SR9011SR9011

    SR9011 is a REV-ERB agonist (IC50: 790 nM, REV-ERBα; IC50: 560 nM, REV-ERBβ).

    价 格:¥电议型 号:T3688产 地:中国大陆

  • T36876SBP1;SBP1SBP1

    Human ACE2 receptor-derived 23-amino acid peptide. Binds receptor binding domain (RBD) of insect-derived SARS-CoV-2 spike protein (KD = 1.3 μM for N-terminal biotinylated, insect-derived spike protein RBD; see Zhang et al preprint publication). Please note - unpublished, in-house data suggests approximately 75-fold lower affinity for insect-derived SARS-CoV-2 RBD than reported by Zhang et al.

    价 格:¥电议型 号:T36876产 地:中国大陆

  • T36680SM1-71;化合物 SM1-71SM1-71

    SM1-71 is a potent multi-targeted acrylamide-modified TAK1 inhibitor that inhibits MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC, YES1, FGFR1, ZAK (MLTK), MAP3K1, LIMK1 and RSK2.SM1-71 can be used as a kinase probe with anticancer activity and inhibits the proliferation of various cancer cell lines.

    价 格:¥电议型 号:T36680产 地:中国大陆

  • T3646RSL3;化合物1S,3R-RSL3RSL3 1S|||1S,3R-RSL3;RSL3 1S|||1S,3R-RSL3

    RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM). RSL3 is a VDAC-independent activator of iron death that is selective for tumor cells carrying oncogenic RAS.

    价 格:¥电议型 号:T3646产 地:中国大陆

  • T36438Sporogen-AO 1;Sporogen-AO 1Sporogen-AO 1

    Sporogen-AO 1 is a fungal metabolite originally isolated fromA. oryzaethat has diverse biological activities.1,2,3,4,5It inhibits HIV-1 Tat transactivation in a cell-based assay with an IC50value of 15.8 μM.4Sporogen-AO 1 is cytotoxic to HeLa, KB, and NCI H187 cancer cells (IC50s = 8.3, 9, and 5.1 μM, respectively).2,5It is active againstC. albicans(MIC = 4 mM).3

    价 格:¥电议型 号:T36438产 地:中国大陆

  • T36376SB-612111;SB-612111SB-612111

    SB-612111 is a novel and potent human opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 (Ki=0.33 nM). SB-612111 exhibits selectivity for μ-, κ- and δ-receptors with Ki values of 57.6 nM, 160.5 nM and 2109 nM, respecticely. SB-612111 effectively antagonizes the pronociceptive action of Nociceptin in an acute pain model[1].

    价 格:¥电议型 号:T36376产 地:中国大陆

  • T3627IQ-1S free acid;化合物IQ-1SIQ-1|||IQ-1S|||IQ-1S (free acid);IQ-1|||IQ-1S|||IQ-1S (free acid)

    IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity. IQ-1S can reduce inflammation and cartilage loss associated with CIA and can serve as a small-molecule modulator for mechanistic studies of JNK function in rheumatoid arthritis. IQ-1S is highly specific for JNK and that its neutral form is the most abundant species at physiologic pH.

    价 格:¥电议型 号:T3627产 地:中国大陆

  • T36244SJF 1521;SJF 1521SJF 1521

    Selective EGFR Degrader. Comprises the EGFR inhibitor lapatinib joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Exhibits selectivity for EGFR, including mutant forms, over HER2. Induces degradation of EGFR in OVCAR8 cells.

    价 格:¥电议型 号:T36244产 地:中国大陆

  • T36090S14161S14161S-14161|||S14161

    S14161 has a wide range of applications in life science related research.

    价 格:¥电议型 号:T36090产 地:中国大陆

  • T3593Src Inhibitor 1;化合物Src Inhibitor 1Src Kinase Inhibitor 1|||Src-l1;Src Kinase Inhibitor 1|||Src-l1

    Src Inhibitor 1 (Src Kinase Inhibitor 1) is a potent and selective dual site Src tyrosine kinase inhibitor.

    价 格:¥电议型 号:T3593产 地:中国大陆

  • T35524(1S)-Calcitriol;(1S)-Calcitriol(1S)-Calcitriol

    (1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3), a natural metabolite of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3), exerts potent actions through vitamin D receptor (VDR) activation, including the inhibition of keratinocyte growth and suppression of parathyroid hormone secretion[1].

    价 格:¥电议型 号:T35524产 地:中国大陆

  • T34951Trimopam;化合物 T34951Sch12679|||Sch 2679|||Sch-12679;Sch12679|||Sch 2679|||Sch-12679

    Trimopam is a dopamine receptor agonist of the benzazepine group.

    价 格:¥电议型 号:T34951产 地:中国大陆

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