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T61431Topoisomerase IIα-IN-4;化合物 Topoisomerase IIα-IN-4Topoisomerase IIα-IN-4
Topoisomerase IIα-IN-4 (F2) is a non-intercalative ATP-competitive inhibitor of human DNA topoisomerase II, specifically inhibiting TopoIIα with an IC50 value of 3.8 μM and TopoIIβ with an IC50 value of 10.1 μM. It demonstrates significant efficacy in inducing apoptosis and arresting the cell cycle in HepG2 cells. Moreover, Topoisomerase IIα-IN-4 exhibits robust antitumor effects against various human cancer cell lines, making it a valuable compound for cancer research [1].
价 格:¥电议型 号:T61431产 地:中国大陆
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T61430S-2E;化合物 S-2ES-2E
S-2E is a compound that functions as an orally active, noncompetitive inhibitor of both HMG-CoA reductase and acetyl-CoA carboxylase. It exhibits an anti-hyperlipidemic action, making it suitable for studying conditions such as familial hypercholesterolemia and mixed hyperlipidemia [1] [2].
价 格:¥电议型 号:T61430产 地:中国大陆
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T6143PI-103;化合物PI103PI103|||PI 103;PI103|||PI 103
PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).
价 格:¥电议型 号:T6143产 地:中国大陆
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T61143Antitubercular agent-18;化合物 Antitubercular agent-18Antitubercular agent-18
Antitubercular agent-18 (Compound 9a) is an antitubercular agent that exhibits highly selective antimycobacterial effects, with minimum inhibitory concentration (MIC) values of 2 μg/ml against M. tuberculosis H37Rv, Spec. 192, and Spec. 210, and 128 μg/ml against Spec. 800, demonstrating its efficacy in inhibiting the growth of these mycobacterial strains [1].
价 格:¥电议型 号:T61143产 地:中国大陆
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T60747LY3143921;化合物 LY3143921LY3143921
LY3143921 ((S)-Example 2) is an orally active inhibitor of CDC7 kinase with broad in vitro anticancer activity [1].
价 格:¥电议型 号:T60747产 地:中国大陆
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T60143MitoBloCK-6;化合物MitoBloCK-6MitoBloCK-6
MitoBloCK-6 is a potent Erv1/ALR inhibitor, with an IC 50 of 900 nM and 700 nM, respectively. MitoBloCK-6 also inhibits Erv2 with IC 50 of 1.4 μM. MitoBloCK-6 can induce apoptosis via cytochrome c release in human embryonic stem cells (hESCs) [1].
价 格:¥电议型 号:T60143产 地:中国大陆
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T5353ABX-1431;化合物ABX-1431Elcubragistat;Elcubragistat
ABX-1431 (Elcubragistat) is a selective and orally available CNS-penetrant monoacylglycerol lipase (MAGL/MGLL) inhibitor (IC50: 14 nM).
价 格:¥电议型 号:T5353产 地:中国大陆
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T5174Nestoron;醋酸烯诺孕酮ST-1435|||Segesterone Acetate|||Nestorone|||Elcometrine;醋酸烯诺孕酮|||ST-1435|||Segesteron
Nestoron (Segesterone Acetate), a synthetic progestin, is a high-affinity agonist of the progesterone receptor (EC50: 10.3 nM).
价 格:¥电议型 号:T5174产 地:中国大陆
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T5143Corynoxine hydrochloride(6877-32-3(free base));盐酸柯诺辛Corynoxine hydrochloride(6877-32-3(free base))
Corynoxine hydrochloride is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.
价 格:¥电议型 号:T5143产 地:中国大陆
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T4967NPS-2143 hydrochloride;化合物NPS-2143 HCLNPS-2143 HCL;2-氯-6-[(2R)-3-[[1,1-二甲基-2-(2-萘基)乙基]氨基]-2-羟基丙氧基]苯腈
NPS-2143 hydrochloride (NPS-2143 HCL) is a selective potent calcium ion-sensing receptor antagonist.
价 格:¥电议型 号:T4967产 地:中国大陆
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T4183lavendustin A;薰草菌素RG-14355|||NSC 678027;RG-14355|||NSC 678027|||薰草菌素
lavendustin A (RG-14355) is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.
价 格:¥电议型 号:T4183产 地:中国大陆
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T41143pCPA methyl ester hydrochloride;4-氯-DL-苯基丙氨酸甲酯盐酸盐4-Chloro-DL-phenylalanine methyl ester hydrochlorid
pCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) is an inhibitor of tryptophan hydroxylase inhibitor and 5-HT synthesis. pCPA methyl ester hydrochloride is permeable across the blood-brain barrier and reduces 5-HT central availability.
价 格:¥电议型 号:T41143产 地:中国大陆
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T40274XVA143XVA143XVA143
XVA143, an α/β I-like allosteric antagonist, effectively blocks LFA-1 dependent firm adhesion but simultaneously increases adhesion under shear flow and rolling conditions, both in vitro and in vivo.
价 格:¥电议型 号:T40274产 地:中国大陆
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T40143PROTAC CBP/P300 Degrader-1;PROTAC CBP/P300 Degrader-1PROTAC CBP/P300 Degrader-1;PROTAC CBP/P300 Degr
PROTAC CBP/P300 Degrader-1 is an effective compound that degrades CBP/P300 in a potent manner. It significantly reduces cell viability in various cancer cell lines.
价 格:¥电议型 号:T40143产 地:中国大陆
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T39874GSK143 dihydrochloride;GSK143 dihydrochlorideGSK143 dihydrochloride
GSK143 dihydrochloride is a highly selective, orally active inhibitor of spleen tyrosine kinase (SYK), exhibiting a pIC 50 value of 7.5. It effectively inhibits phosphorylated Erk (pErk) with a pIC 50 value of 7.1. The compound demonstrates anti-inflammatory properties and hinders the recruitment of immune cells in the intestinal muscularis of mice.
价 格:¥电议型 号:T39874产 地:中国大陆
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T39143Y12196;Y12196Y12196
Y12196, a newly developed succinate dehydrogenase inhibitor (SDHI), demonstrates potent fungicidal effects specifically targeting F. graminearum.
价 格:¥电议型 号:T39143产 地:中国大陆
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T39129BMS-986143;BMS-986143BMS-986143
BMS-986143, an orally active, reversible BTK inhibitor with an IC50 value of 0.26 nM, is designed for autoimmune disease research. Additionally, it targets TEC, BLK, BMX, TXK, FGR, YES1, and ITK, exhibiting IC50s of 3 nM, 5 nM, 7 nM, 10 nM, 15 nM, 19 nM, and 21 nM, respectively [1].
价 格:¥电议型 号:T39129产 地:中国大陆
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T38626GSK143;GSK143GSK143
GSK143 is a potent orally active and highly selective inhibitor of spleen tyrosine kinase (SYK) with a pIC 50 of 7.5. Furthermore, GSK143 effectively inhibits phosphorylated Erk (pErk) with a pIC 50 value of 7.1. In addition, GSK143 exhibits promising anti-inflammatory properties by reducing inflammation and impeding the recruitment of immune cells in the intestinal muscularis of mice.
价 格:¥电议型 号:T38626产 地:中国大陆
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T38385IT-143B;IT-143BIT-143B
IT-143B is a bacterial metabolite that has been found in S. iakyrus.1 It inhibits the proliferation of OS-RC-2 and ACHN cancer cells (IC50s = 22 and 98 μM, respectively).
价 格:¥电议型 号:T38385产 地:中国大陆
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T38143ElaidamideElaidamideElaidamide
Elaidamide is a fatty acid amide that has been found in the cerebrospinal fluid of sleep-deprived cats. It inhibits rat microsomal epoxide hydrolase (mEH; Ki = 70 nM). Elaidamide also inhibits porcine pancreatic and human synovial phospholipase A2 (PLA2).
价 格:¥电议型 号:T38143产 地:中国大陆