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T18176m-PEG25-Propargyl;化合物 T18176m-PEG25-Propargyl
m-PEG25-Propargyl is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T18176产 地:中国大陆
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T17699Bromo-PEG24-Boc;化合物 T17699Bromo-PEG24-Boc
Bromo-PEG24-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T17699产 地:中国大陆
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T17698Bromo-PEG1-C2-azide;化合物Bromo-PEG1-C2-azideBromo-PEG1-C2-azide
Bromo-PEG1-C2-azide is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
价 格:¥电议型 号:T17698产 地:中国大陆
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T17697BRD7-IN-1;化合物BRD7-IN-1BRD7-IN-1
BRD7-IN-1, a modified derivative of BI7273 (BRD7/9 inhibitor), forms PROTAC VZ185 through linkage to a VHL ligand, demonstrating potent activity against BRD7/9 with DC50 values of 4.5 and 1.8 nM, respectively [1].
价 格:¥电议型 号:T17697产 地:中国大陆
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T17696BRD7-IN-1 free base;化合物 T17696BRD7-IN-1 free base
BRD7-IN-1 free base, a modified derivative of BI7273 (BRD7/9 inhibitor), interacts with a VHL ligand through a linker, constituting the PROTAC VZ185 (targeting BRD7/9 with DC50 values of 4.5 and 1.8 nM, respectively)[1].
价 格:¥电议型 号:T17696产 地:中国大陆
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T17695Br-PEG7-Br溴代-八聚乙二醇-溴代溴代-八聚乙二醇-溴代
Br-PEG7-Br is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
价 格:¥电议型 号:T17695产 地:中国大陆
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T17694Br-C10-methyl ester11-溴代十一烷酸甲酯11-溴代十一烷酸甲酯
Br-C10-methyl ester, a PROTAC linker characterized by its alkyl/ether composition, plays a crucial role in the synthesis of a series of PROTACs (MS432). This compound incorporates a dual-ligand system connected via a linker; notably, one ligand interacts with the VHL portion.
价 格:¥电议型 号:T17694产 地:中国大陆
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T17693Boc-Val-Cit-PAB;化合物Boc-Val-Cit-PABBoc-Val-Cit-PAB
Boc-Val-Cit-PAB is a cleavable ADC linker. Boc-Val-Cit-PAB used in the synthesis of antibody-drug conjugates (ADCs).
价 格:¥电议型 号:T17693产 地:中国大陆
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T17692Boc-Val-Cit-PAB-PNP;化合物Boc-Val-Cit-PAB-PNPinhibit|||Antibody-drug conjugates linkers|||BocValCitPABP
Boc-Val-Cit-PAB-PNP is a cleavable ADC linker used in antibody-drug conjugates (ADCs) synthesis.
价 格:¥电议型 号:T17692产 地:中国大陆
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T17691Boc-Val-Cit-OH;化合物Boc-Val-Cit-OHBoc-Val-Cit-OH
Boc-Val-Cit-OH is a cleavable ADC linker used in antibody-drug conjugates (ADCs) synthesis.
价 格:¥电议型 号:T17691产 地:中国大陆
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T17690Boc-Val-Ala-PAB-PNP;化合物 T17690Boc Val Ala PAB PNP|||Boc-Val-Ala-PAB-PNP|||BocValAlaPABPNP;Boc Val Al
Boc-Val-Ala-PAB-PNP is an ADC linker employed for the synthesis of antibody-drug conjugates (ADCs)[1]. This cleavable compound efficiently facilitates the attachment of drugs to antibodies, allowing for targeted delivery and release of therapeutic agents within the body, making it an important component in ADC development.
价 格:¥电议型 号:T17690产 地:中国大陆
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T1769Pardoprunox;帕多芦诺SLV-308|||DU-126891;帕多芦诺|||SLV-308|||DU-126891
Pardoprunox (SLV-308) is a partial dopamine D2 agonist and noradrenergic agonist with serotonin 5-HT1A agonist properties. Pardoprunox has been used in trials studying the treatment of Early Stage Parkinson´s Disease and Advanced Stage Parkinson´s Disease.
价 格:¥电议型 号:T1769产 地:中国大陆
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T17689Boc-Pip-alkyne-Ph-COOH;化合物 T17689Boc-Pip-alkyne-Ph-COOH
Boc-Pip-alkyne-Ph-COOH, a PROTAC linker characterized by its alkyl/ether composition, plays a crucial role in synthesizing PROTACs including ARD-266. This compound demonstrates significant efficacy in promoting the degradation of androgen receptor (AR) protein across AR-positive prostate cancer cell lines such as LNCaP, VCaP, and 22Rv1, showcasing DC50 values ranging from 0.2-1 nM[1].
价 格:¥电议型 号:T17689产 地:中国大陆
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T17688Boc-Phe-(Alloc)Lys-PAB-PNP;化合物 T17688Boc-Phe-(Alloc)Lys-PAB-PNP|||BocPhe(Alloc)LysPABPNP|||Boc Phe (
Boc-Phe-(Alloc)Lys-PAB-PNP serves as a cleavable linker in the synthesis of antibody-drug conjugates (ADCs).
价 格:¥电议型 号:T17688产 地:中国大陆
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T17687Boc-PEG4-sulfone-PEG4-Boc;化合物 T17687Boc-PEG4-sulfone-PEG4-Boc
Boc-PEG4-sulfone-PEG4-Boc is a polyethylene glycol (PEG)-derived linker specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
价 格:¥电议型 号:T17687产 地:中国大陆
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T17686Boc-PEG4-C2-NHS ester;化合物 T17686Boc-PEG4-C2-NHS ester
Boc-PEG4-C2-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T17686产 地:中国大陆
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T17685Boc-NH-PEG9-propargyl;化合物 T17685Boc-NH-PEG9-propargyl
Boc-NH-PEG9-propargyl is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T17685产 地:中国大陆
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T17684Boc-NH-PEG8-CH2CH2NH2叔丁氧羰基八聚乙二醇胺叔丁氧羰基八聚乙二醇胺
Boc-NH-PEG8-CH2CH2NH2 is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
价 格:¥电议型 号:T17684产 地:中国大陆
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T17683Boc-NH-PEG8-CH2CH2COOHN-叔丁氧羰基-七聚乙二醇-羧酸N-叔丁氧羰基-七聚乙二醇-羧酸
Boc-NH-PEG8-CH2CH2COOH is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
价 格:¥电议型 号:T17683产 地:中国大陆
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T17682Boc-NH-PEG7-Tos;化合物Boc-NH-PEG7-Tost-Boc-N-Amido-PEG7-Tos;t-Boc-N-Amido-PEG7-Tos
Boc-NH-PEG7-Tos (t-Boc-N-Amido-PEG7-Tos) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.
价 格:¥电议型 号:T17682产 地:中国大陆