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T7753Thalidomide-O-COOH；化合物Thalidomide-O-COOHinhibit|||Ligands for E3 Ligase|||TCE35031|||ThalidomideOCOO
Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. It can be connected to the ligand for protein by a linker to form PROTACs.
价 格：￥电议型 号：T7753产 地：中国大陆
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T7752(S,R,S)-AHPC-Me；化合物(S,R,S)-AHPC-MeVHL ligand 2|||E3 ligase Ligand 1A；VHL ligand 2|||E3 ligase Ligand
(S,R,S)-AHPC-Me (E3 ligase Ligand 1A) (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me can be used to synthesize ARV-771. ARV-771 is a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM.
价 格：￥电议型 号：T7752产 地：中国大陆
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T76856Andecaliximab；Andecaliximab单抗GS-5745；GS-5745
Andecaliximab is a recombinant IgG4 monoclonal antibody targeting matrix metalloproteinase 9 (MMP9). Andecaliximab showed antifibrotic effects in a mouse model of idiopathic pulmonary fibrosis. Andecaliximab can be used to study gastric adenocarcinoma and idiopathic pulmonary fibrosis (IPF), as well as dengue virus.
价 格：￥电议型 号：T76856产 地：中国大陆
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T76568Aminopeptidase N Ligand (CD13) NGR peptide；化合物 Aminopeptidase N Ligand (CD13) NGR peptideAminopeptid
Aminopeptidase N Ligand (CD13) NGR peptide, a polypeptide that targets CD13, functions as a carrier for mediating intracellular transmission and is commonly utilized in cancer research [1] [2].
价 格：￥电议型 号：T76568产 地：中国大陆
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T76343-Hydroxymandelic Acid；3-羟基扁桃酸3-Hydroxymandelic Acid
3-Hydroxymandelic Acid is a metabolite of Phenylephrine.
价 格：￥电议型 号：T7634产 地：中国大陆
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T75712Aminocandin；化合物 AminocandinAminocandin
Aminocandin (HMR 3270), a water-soluble echinocandin class antifungal agent, exhibits exceptional efficacy against Aspergillus and Candida species [1].
价 格：￥电议型 号：T75712产 地：中国大陆
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T75617Salviandulin E；化合物 Salviandulin ESalviandulin E
Salviandulin E, a diterpenoid isolated from Salvia leucantha CAV., exhibits antitrypanosomal activity against T. b. brucei GUTat 3.1 parasites, demonstrating an IC50 value of 0.72 ?g/mL [1] [2].
价 格：￥电议型 号：T75617产 地：中国大陆
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T755066-Acetylnimbandiol；化合物 6-Acetylnimbandiol6-Acetylnimbandiol
6-Acetylnimbandiol (6-O-Acetylnimbandiol), a non-cytotoxic tyrosinase inhibitor (IC 50 = 69.85 μM), effectively inhibits melanin production and MITF expression, making it valuable for melanoma research [1].
价 格：￥电议型 号：T75506产 地：中国大陆
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T75450P-orlandin；化合物 P-orlandinP-orlandin
P-orlandin, a fungal metabolite, effectively impedes Plasmodium falciparum infection in mosquitoes by preventing FREP1 from binding to gametocytes or ookinetes [1].
价 格：￥电议型 号：T75450产 地：中国大陆
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T74654Neuropeptide Y5 receptor ligand-1；化合物 Neuropeptide Y5 receptor ligand-1Neuropeptide Y5 receptor liga
Neuropeptide Y5 receptor ligand-1 (Compound 54), a carbazole derivative, acts as a powerful antagonist to the neuropeptide Y5 (NPY-5) receptor [1].
价 格：￥电议型 号：T74654产 地：中国大陆
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T74571TSPO Ligand-Linker Conjugates 1；化合物 TSPO Ligand-Linker Conjugates 1TSPO Ligand-Linker Conjugates 1
TSPO Ligand-Linker Conjugates 1, comprising a translocator protein (TSPO) ligand and a linker, is instrumental in synthesizing mitochondria-targeting autophagy-targeting chimera (AUTAC). This compound binds TSPO on the outer mitochondrial membrane (OMM), facilitating the degradation of malfunctioning mitochondria and proteins through mitophagy, thereby enhancing mitochondrial function. It holds potential applications in research related to mitochondrial dysfunction, encompassing neurodegenerativ
价 格：￥电议型 号：T74571产 地：中国大陆
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T74492CD22 ligand-1；化合物 CD22 ligand-1CD22 ligand-1
CD22 Ligand-1 (Compound 12) is a potent, selective ligand for CD22, exhibiting dissociation constants (K_D) of 0.335 ?M for human CD22 (hCD22) and 30.7 ?M for myelin-associated glycoprotein (MAG), indicating specificity towards hCD22. This ligand holds potential for B-cell related disease research [1].
价 格：￥电议型 号：T74492产 地：中国大陆
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T74399Heterobivalent ligand-1；化合物 Heterobivalent ligand-1Heterobivalent ligand-1
Heterobivalent ligand-1 (compound 26) serves as a heterobivalent ligand targeting the Adenosine A 2A-dopamine D 2 receptor heteromer, exhibiting binding affinities of K DB1 A 2A R=2.1 nM and K DB1 D 2 R= 0.13 nM [1].
价 格：￥电议型 号：T74399产 地：中国大陆
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T74173PROTAC PARP/EGFR ligand 1；化合物 PROTAC PARP/EGFR ligand 1PROTAC PARP/EGFR ligand 1
PROTAC PARP/EGFR ligand 1 is a potent compound utilized in the creation of dual PARP-EGFR degraders through Proteolytic Targeting Chimera (PROTAC) technology [1].
价 格：￥电议型 号：T74173产 地：中国大陆
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T74137PROTAC Bcl-xL ligand-1；化合物 PROTAC Bcl-xL ligand-1PROTAC Bcl-xL ligand-1
PROTAC Bcl-xL ligand-1 serves as a ligand targeting Bcl-xL, essential in synthesizing PROTACs [1].
价 格：￥电议型 号：T74137产 地：中国大陆
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T7412Tandospirone citrate；坦度螺酮柠檬酸盐SM-3997 citrate；SM-3997 citrate|||坦度螺酮柠檬酸盐|||枸橼酸坦度螺酮
Tandospirone citrate (SM-3997 citrate) is a potent and selective 5-HT1A receptor partial agonist (Ki : 27 nM)
价 格：￥电议型 号：T7412产 地：中国大陆
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T73941PROTAC BCR-ABL1 ligand 1；化合物 PROTAC BCR-ABL1 ligand 1PROTAC BCR-ABL1 ligand 1
GMB-475, also known as PROTAC BCR-ABL1 ligand 1, allosterically targets and binds to the BCR-ABL1 protein. It effectively recruits the E3 ligase Von Hippel-Lindau, leading to the ubiquitination and subsequent degradation of BCR-ABL1 [1].
价 格：￥电议型 号：T73941产 地：中国大陆
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T73782Prostaglandin J2；化合物 Prostaglandin J2Prostaglandin J2
Prostaglandin J2 (PGJ2), a derivative of Prostaglandin D2 (PGD2), serves as a potent agonist for PGD2 receptors (DP), exhibiting affinity constants (K i) of 0.9 nM and 6.6 nM for hDP and hCRTH2 receptors, respectively. It activates cyclic AMP production with an EC50 of 1.2 nM, induces oxidative stress, neuronal apoptosis, and promotes the accumulation of ubiquitinated (Ub) proteins. Notably, PGJ2´s neurotoxic properties are implicated in the progression of neurodegenerative diseases such a
价 格：￥电议型 号：T73782产 地：中国大陆
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T7378011β-Hydroxyandrosterone；化合物 11β-Hydroxyandrosterone11β-Hydroxyandrosterone
11β-Hydroxyandrosterone, an 11-oxygenated androgen metabolite, is derived from 11β-hydroxyandrostenedione [1] [2].
价 格：￥电议型 号：T73780产 地：中国大陆
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T736717β-Hydroxy-epi-androsterone；化合物 7β-Hydroxy-epi-androsterone7β-Hydroxy-epi-androsterone
7β-Hydroxy-epi-androsterone (7β-Hydroxy-EpiA) is an endogenous androgenic derivative of dehydroepiandrosterone that possesses the ability to bind to ERβ, offering both anti-inflammatory and neuroprotective properties [1] [2] [3].
价 格：￥电议型 号：T73671产 地：中国大陆
