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T15407GNE-0723；化合物 T15407GNE-0723
GNE 0723 is an NMDAR brain permeable positive allosteric modulator (EC50: 21 nM for GluN2A; 7.4 and 6.2 μM for GluN2C and GluN2D, respectively).
价 格：￥电议型 号：T15407产 地：中国大陆
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T15406GNE-955；化合物 T15406GNE-955
GNE-955 is a potent and orally active inhibitor of pan Pim kinase (Kis: 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively).
价 格：￥电议型 号：T15406产 地：中国大陆
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T15405GNE-781；GNE-781GNE-781
GNE-781 is a highly potent and selective inhibitor of CBP (IC50: 0.94 nM in TR-FRET assay). GNE-781 also inhibits BRET and BRD4(1) (IC50s: 6.2 nM and 5100 nM, respectively).
价 格：￥电议型 号：T15405产 地：中国大陆
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T15404GNE-6468；化合物 T15404GNE-6468
GNE-6468 is a potent and selective agonist of RORγ(RORc) (EC50: 13 nM for HEK-293 cell).
价 格：￥电议型 号：T15404产 地：中国大陆
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T15403GNE-618；化合物 T15403GNE-618
GNE-618 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (IC50: 6 nM). GNE-618 depletes NAD levels and induces tumor cell death. It has anti-tumor activity.
价 格：￥电议型 号：T15403产 地：中国大陆
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T15402GNE-4997；化合物 T15402GNE-4997
GNE-4997 is a potent and selective inhibitor of the interleukin-2-inducible T-cell kinase (Ki: 0.09 nM). The correlation between the basicity of solubilizing elements in GNE-4997 and off-target antiproliferative effects decreases cytotoxicity.
价 格：￥电议型 号：T15402产 地：中国大陆
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T15400GNE-272；化合物 T15400GNE-272
GNE-272 is a selective inhibitor of CBP/EP300 (IC50: 0.02, 0.03, and 13 μM for CBP, EP300, and BRD4, respectively) and a selective in vivo probe for CBP/EP300.
价 格：￥电议型 号：T15400产 地：中国大陆
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T15399GNE-207；化合物 T15399GNE-207
GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM). It has a selective index of >2500-fold against BRD4 (1). GNE-207 displays excellent CBP potency (EC50: 18 nM for MYC expression in MV-4-11 cells).
价 格：￥电议型 号：T15399产 地：中国大陆
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T15398GNE-0946；化合物 T15398GNE-0946
GNE-0946 is a potent and selective agonist of RORγ (EC50: 4 nM for HEK-293 cell).
价 格：￥电议型 号：T15398产 地：中国大陆
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T15397GNE-049；化合物 T15397GNE-049
GNE-049 is a highly potent and selective inhibitor of CBP (IC50: 1.1 nM in TR-FRET assay). GNE-049 also inhibits BRET and BRD4(1) (IC50s: 12 nM and 4200 nM, respectively).
价 格：￥电议型 号：T15397产 地：中国大陆
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T15342Fosravuconazole；化合物 T15342E-1224|||BMS-379224；E-1224|||BMS-379224
Fosravuconazole is a ravuconazole prodrug. It has antifungal activity.
价 格：￥电议型 号：T15342产 地：中国大陆
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T15326Fmoc-NMe-PEG4-C2-acid；化合物 T15326Fmoc-NMe-PEG4-C2-acid
Fmoc-NMe-PEG4-C2-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格：￥电议型 号：T15326产 地：中国大陆
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T15240Tazemetostat trihydrochloride；化合物 T15240EPZ-6438 trihydrochloride|||E-7438 trihydrochloride；EPZ-6438
Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing wild-type EZH2 (Ki: 2.5 nM). It inhibits EZH2 (IC50s: 11 and 16 nM in peptide assay and nucleosome assay).
价 格：￥电议型 号：T15240产 地：中国大陆
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T15189Thalidomide-O-amido-C4-N3；化合物Thalidomide-O-amido-C4-N3E3 ligase Ligand-Linker Conjugates 18|||Cerebl
Thalidomide-O-amido-C4-N3 (Cereblon Ligand-Linker Conjugates 4) is an E3 ligase ligand-linker conjugate incorporating the Thalidomide-based cereblon ligand and a linker.
价 格：￥电议型 号：T15189产 地：中国大陆
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T15188E-?6123；化合物 T15188E-?6123
E-6123 is an antagonist of platelet-activating factor (PAF) receptor.
价 格：￥电议型 号：T15188产 地：中国大陆
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T15187E-5324；化合物 T15187E-5324
E-5324 is potent cholesterol acyltransferase (ACAT) inhibitor (IC50s: 44 to 190 nM).
价 格：￥电议型 号：T15187产 地：中国大陆
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T15185Lucitanib；德立替尼E-3810；E-3810|||德立替尼
Lucitanib (E-3810) is a novel VEGFR and FGFR inhibitor. It potently and selectively inhibits VEGFR1, VEGFR2, VEGFR3, FGFR1 and FGFR2 (IC50s: 7 nM, 25 nM, 10 nM, 17.5 nM, and 82.5 nM, respectively).
价 格：￥电议型 号：T15185产 地：中国大陆
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T15096Delgocitinib；迪高替尼JTE-052|||Corectim（Delgocitinib）；JTE-052|||迪高替尼|||Corectim（Delgocitinib）
Delgocitinib (JTE-052) is a specific JAK (Janus kinase) inhibitor with IC50 values of 2.8, 2.6, 13, and 58 nM for JAK1, JAK2, JAK3, and Tyk2 respectively. Delgocitinib is involved in various inflammatory and autoimmune diseases through JAK-dependent cytokines, and can effectively suppress multiple cytokine signaling while inhibiting itching caused by cytokines. It is widely used to treat various inflammatory diseases, including autoimmune diseases and hypersensitivity reactions.
价 格：￥电议型 号：T15096产 地：中国大陆
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T14941CGP37157；CGP371577-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one；7-Chloro-5-(2
CGP37157 (7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one) is a Na+/Ca2+ exchanger inhibitor, inhibits Na+-induced Ca2+ release from mitochondria in guinea pig heart with IC50 of 0.8 μM.
价 格：￥电议型 号：T14941产 地：中国大陆
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T14926Centrinone-B；化合物 T14926LCR-323；LCR-323
Centrinone-B (LCR-323) is a potent and highly selective inhibitor of PLK4 (Ki: 0.59 nM).
价 格：￥电议型 号：T14926产 地：中国大陆
