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  • T14908CCT367766；化合物CCT367766CCT367766

    CCT367766 is a potent, PROTAC-based, third-generation, iso-functional pirin-targeted protein degradation probe (PDP) that depletes pirin expression at low concentrations.CCT367766 has an IC50 value of 490 nM for the CRBN-DDB1 complex.CCT367766 has a good affinity for recombinant pirin and CRBN. CCT367766 has a good affinity for recombinant pirin and CRBN, with Kd values of 55 nM and 120 nM, respectively. cct367766 is a potent orally active protein that reduces the expression of pirin at low conc

    价 格：￥电议型 号：T14908产 地：中国大陆

  • T1488Procarbazine hydrochloride；盐酸甲基苄肼NSC-77213 HCl|||Procarbazine HCl；NSC-77213 HCl|||盐酸甲基苄肼|||Procarbaz

    Procarbazine hydrochloride (NSC-77213 HCl) is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic fre

    价 格：￥电议型 号：T1488产 地：中国大陆

  • T14877Cauloside C；葳岩仙皂苷 CCauloside C

    Cauloside C, a triterpene glycoside isolated from Caulophyllum robustum Max, exerts anti-inflammatory effects through the inhibition of expression of iNOS and proinflammatory cytokines.

    价 格：￥电议型 号：T14877产 地：中国大陆

  • T1485Methotrexate；甲氨蝶呤NCI-C04671|||WR19039|||Amethopterin|||CL14377；NCI-C04671|||WR19039|||Amethopterin||

    Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and various tumors.

    价 格：￥电议型 号：T1485产 地：中国大陆

  • T14779BRD7389；化合物BRD7389BRD7389

    BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.

    价 格：￥电议型 号：T14779产 地：中国大陆

  • T14778BRD6989；化合物BRD6989BRD6989

    BRD6989 is an analog of the natural product cortistatin A (dCA). Which inhibits CDK8 and upregulates IL-10. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes. BRD6989 selectively binds a complex of CDK8 with an IC50 of ~200 nM.

    价 格：￥电议型 号：T14778产 地：中国大陆

  • T14777BRD5529；化合物 T14777BRD5529

    BRD5529 is a selective inhibitor of CARD9-E3 ubiquitin ligase TRIM62 protein-protein interaction (IC50: 8.6 μM). BRD5529 directly and selectively binds CARD9, disrupts TRIM62 recruitment, inhibits TRIM62-mediated ubiquitinylation, and activation of CARD9.

    价 格：￥电议型 号：T14777产 地：中国大陆

  • T14776BRD4 Inhibitor-10；化合物BRD4 Inhibitor-10BRD4 Inhibitor-10

    BRD4 Inhibitor-10 is an inhibitor of BRD4-BD1 (IC50: 8 nM).

    价 格：￥电议型 号：T14776产 地：中国大陆

  • T14775Bragsin2；化合物Bragsin26-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one|||Bragsin 2；6-methoxy-5-nitro

    Bragsin2 (6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one) is a hydration-resistant cell penetrant, selective and non-competitive inhibitor of Afr guanine nucleotide exchange factor BRAG2 that inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin2 binds at the interface between the pleckstrin homology domain of BRAG2 and the lipid bilayer, leading BRAG2 unable to activate lipidated Arf GTPase.

    价 格：￥电议型 号：T14775产 地：中国大陆

  • T14774Bragsin1；化合物 T14774Bragsin1

    Bragsin1 is a potent and selective and noncompetitive ArfGEF BRAG2 inhibitor, inhibits Arf GTPase activation(IC50 : 3 μM),and with anti-cancer activity.

    价 格：￥电议型 号：T14774产 地：中国大陆

  • T14773Br-PEG4-OH；化合物 T14773Br-PEG4-OH

    Br-PEG4-OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

    价 格：￥电议型 号：T14773产 地：中国大陆

  • T14772Br-PEG4-CH2-Boc；化合物 T14772Br-PEG4-CH2-Boc

    Br-PEG4-CH2-Boc, a PEG- and Alkyl/ether-based PROTAC linker, serves as a valuable component for the synthesis of PROTACs[1].

    价 格：￥电议型 号：T14772产 地：中国大陆

  • T14771Br-PEG4-C2-Boc；化合物 T14771Br-PEG4-C2-Boc

    Br-PEG4-C2-Boc is a cleavable 4-unit PEG ADC linker employed for the synthesis of antibody-drug conjugates (ADCs)[1].

    价 格：￥电议型 号：T14771产 地：中国大陆

  • T14770Br-PEG3-OH；化合物 T14770Br-PEG3-OH

    Br-PEG3-OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

    价 格：￥电议型 号：T14770产 地：中国大陆

  • T14681BMS-935177；化合物BMS-935177BMS-935177

    BMS-935177 is a reversible BTK inhibitor with IC50 value of 3 nM.

    价 格：￥电议型 号：T14681产 地：中国大陆

  • T14677BMS-690514；化合物BMS-690514BMS-690514

    BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.

    价 格：￥电议型 号：T14677产 地：中国大陆

  • T14577Biotin-DADOO化合物Biotin-DADOOEZ-Link Amine-PEO2-Biotin|||Biotinyl-3,6-dioxaoctanediamine

    Biotin-DADOO (Biotinyl-3,6-dioxaoctanediamine) is a biotinylation reagent that can be used to synthesize a biotin-estradiol conjugate(i.e., biotin-DADOO-estradiol) to develop a direct, broad-range enzyme immunoassay to measure plasma estradiol concentrations.

    价 格：￥电议型 号：T14577产 地：中国大陆

  • T14477Azido-PEG8-C1-NHS ester；化合物 T14477Azido-PEG8-C1-NHS ester

    Azido-PEG8-C1-NHS ester is a polyethylene glycol (PEG)-based linker, specifically designed for the synthesis of proteolysis targeting chimeras (PROTACs)[1].

    价 格：￥电议型 号：T14477产 地：中国大陆

  • T14377AZD5423；化合物AZD5423AZD5423

    AZD5423 is an inhaled, potent, selective, and non-steroidal modulator of glucocorticoid receptor (GR) and it effectively reduces allergen-induced responses in subjects with mild allergic asthma.

    价 格：￥电议型 号：T14377产 地：中国大陆

  • T14325Arterolane；青蒿氧烷OZ 277|||RBx 11160；OZ 277|||青蒿氧烷|||RBx 11160

    Arterolane is an antimalarial compound. For against P. falciparum Ro73 and W2, the IC50s are both 1.1 nM.

    价 格：￥电议型 号：T14325产 地：中国大陆

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