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  • T39874GSK143 dihydrochloride;GSK143 dihydrochlorideGSK143 dihydrochloride

    GSK143 dihydrochloride is a highly selective, orally active inhibitor of spleen tyrosine kinase (SYK), exhibiting a pIC 50 value of 7.5. It effectively inhibits phosphorylated Erk (pErk) with a pIC 50 value of 7.1. The compound demonstrates anti-inflammatory properties and hinders the recruitment of immune cells in the intestinal muscularis of mice.

    价 格:¥电议型 号:T39874产 地:中国大陆

  • T39841TBK1/IKKε-IN-6TBK1/IKKε-IN-6TBK1/IKKε-IN-6

    TBK1/IKKε-IN-6 (example 110) is a potent inhibitor of TBK1 and IKKε, with IC50 values of less than 100 nM for both enzymes.

    价 格:¥电议型 号:T39841产 地:中国大陆

  • T39752CDK12-IN-2;化合物CDK12-IN-2CDK12 inhibitor 2|||CDK12-IN-2;CDK12 inhibitor 2|||CDK12-IN-2

    CDK12-IN-2 (CDK12 inhibitor 2) is an effective and selective inhibitor of CDK12 with an IC50 of 52 nM, >100 μM, >10 μM and 16 μM for CDK12, CDK2, CDK7, and CDK9. CDK12-IN-2 can be used in studies about the function of CDK12.

    价 格:¥电议型 号:T39752产 地:中国大陆

  • T39314JAK1/TYK2-IN-1JAK1/TYK2-IN-1JAK1/TYK2-IN-1

    JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 ( IC 50 = 29 and 41 nM respectively).

    价 格:¥电议型 号:T39314产 地:中国大陆

  • T38692Fabesetron法贝司琼法贝司琼|||FK1052 free base

    Fabesetron (FK1052) is an orally active compound that acts as a dual antagonist, targeting both the 5-HT3 and 5-HT4 receptors. It exhibits efficacy in studying emesis induced by cancer chemotherapy, showing potential for managing both acute and delayed symptoms.

    价 格:¥电议型 号:T38692产 地:中国大陆

  • T38626GSK143;GSK143GSK143

    GSK143 is a potent orally active and highly selective inhibitor of spleen tyrosine kinase (SYK) with a pIC 50 of 7.5. Furthermore, GSK143 effectively inhibits phosphorylated Erk (pErk) with a pIC 50 value of 7.1. In addition, GSK143 exhibits promising anti-inflammatory properties by reducing inflammation and impeding the recruitment of immune cells in the intestinal muscularis of mice.

    价 格:¥电议型 号:T38626产 地:中国大陆

  • T38619GSK1795091GSK1795091CRX-601

    GSK1795091 (CRX-601) is a synthetic TLR4 agonist and immunologic stimulator with demonstrated antitumor activity. It serves as a vaccine adjuvant, enhancing both mucosal and systemic immunity to influenza virus vaccines.

    价 格:¥电议型 号:T38619产 地:中国大陆

  • T38599HPK1-IN-8;HPK1-IN-8HPK1-IN-8;HPK1-IN-8

    HPK1-IN-8 is an allosteric inhibitor that selectively targets the inactive conformation of full-length HPK1.

    价 格:¥电议型 号:T38599产 地:中国大陆

  • T38263TBK1/IKKε-IN-4;TBK1/IKKε-IN-4TBK1/IKKε-IN-4;TBK1/IKKε-IN-4

    TBK1/IKKε-IN-4, a 6-aminopyrazolopyrimidine derivative, serves as a potent, selective inhibitor for TBK1 and IKKε, demonstrating IC50 values of 13 nM and 59 nM, respectively. This compound exhibits significantly reduced activity, by 100- to 1000-fold, against other protein kinases, such as PDK1, PI3K family members, and mTOR[1].

    价 格:¥电议型 号:T38263产 地:中国大陆

  • T37450SSK1;化合物 SSK1SSK1;SSK1

    SSK1 is a compound that selectively kills senescent cells and is a precursor for β-galactosidase, which can reduce the inflammatory response of the body. SSK1 can activate the phosphorylation of p38 MAPK and MKK3/MKK6 in senescent cells, and promote mitochondrial DNA damage in senescent cells.

    价 格:¥电议型 号:T37450产 地:中国大陆

  • T37221GK187;GK187GK187

    GK187 is an inhibitor of Group VIA (GVIA) calcium-independent phospholipase A2 (iPLA2), an enzyme involved in basal cell metabolism. It inhibits GVIA iPLA2 by 99.8% at 0.091 mole fraction in a mixed micelle activity assay and is selective for GVIA iPLA2 over GIVA cPLA2 and GV sPLA2 where it shows less than 25% and 32.8% inhibition, respectively.

    价 格:¥电议型 号:T37221产 地:中国大陆

  • T3722MK-1064;化合物MK1064Urokinase inhibitor 1|||MK 1064;Urokinase inhibitor 1|||MK 1064

    MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA).

    价 格:¥电议型 号:T3722产 地:中国大陆

  • T37098Chk1-IN-5;Chk1-IN-5Chk1-IN-5;Chk1-IN-5

    Chk1-IN-5 is a highly effective inhibitor of checkpoint kinase 1 (Chk1), which hinders the phosphorylation of Chk1 and effectively suppresses tumor growth in a colon cancer xenograft model[1].

    价 格:¥电议型 号:T37098产 地:中国大陆

  • T3709XMD8-87;化合物XMD8-87ACK1-B19;ACK1-B19

    XMD8-87 (ACK1-B19) is a TNK2 inhibitor with activity in the inhibition of TNK2 phosphorylation. XMD8-87 and XMD16-5 potently inhibit phosphorylation of TNK2 truncation mutations found in solid tumor types.

    价 格:¥电议型 号:T3709产 地:中国大陆

  • T36782TAK1-IN-2;TAK1-IN-2TAK1-IN-2;TAK1-IN-2

    TAK1-IN-2 is a potent and selective TAK1 inhibitor, with an IC50> of 2 nM[1].

    价 格:¥电议型 号:T36782产 地:中国大陆

  • T36730Vitamin K1 2,3-epoxide;维他命 K1 2,3-环氧化物Vitamin K1 epoxide|||Phylloquinone oxide|||Vitamin K1 2,3-epox

    Vitamin K1 2,3-epoxide (Phylloquinone oxide) is reduced to vitamin k and is involved in the vitamin k cycle.

    价 格:¥电议型 号:T36730产 地:中国大陆

  • T36247TBK1 control PROTAC? 4;TBK1 control PROTAC? 4TBK1 control PROTAC? 4

    Negative control for TBK1 PROTAC 3i. Binds TBK1 with high affinity, but exhibits no significant degradation of TBK1. PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

    价 格:¥电议型 号:T36247产 地:中国大陆

  • T36095Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt);Histone H2BK12ac (1-22)-GGK-biotin

    Histone H2BK12ac (1-22)-GGK-biotin amide (trifluoroacetate salt) can be used in related research in the field of life sciences, and its product number is T36095.

    价 格:¥电议型 号:T36095产 地:中国大陆

  • T35928NVS-PAK1-C;NVS-PAK1-CNVS-PAK1-C;NVS-PAK1-C

    NVS-PAK1-1 is a potent allosteric inhibitor of PAK1 with an IC 50 of 5 nM for dephosphorylated PAK1 and 6 nM for phosphorylated PAK1 as assessed. Inhibition is ATP-competitive, most likely due to indirect competition due to incompatibility of ATP binding with the DFG-out binding conformation of the allosteric compound. NVS-PAK1-1 has an IC50 of 270 nM against dephosphorylated PAK2 and 720 nM against phosphorylated PAK2 respectively [1].

    价 格:¥电议型 号:T35928产 地:中国大陆

  • T35899JAK1-IN-8化合物JAK1-IN-8JAK1-IN-8

    JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).

    价 格:¥电议型 号:T35899产 地:中国大陆

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